The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.
Population variation in age-related decline in male salivary testosterone.
Abstract
BACKGROUND: Age-related declines in free and bioavailable testosterone are frequently reported for Western populations, but interpopulation variation in this pattern has not previously been investigated. METHODS: Salivary testosterone was measured using a consistently applied protocol on morning samples collected from men in four populations (USA, Congo, Nepal, and Paraguay) representing different geographical, ecological, and cultural settings. RESULTS: Mean testosterone levels varied significantly between the four populations. The mean testosterone differences between populations were greatest for young men (aged 15-30 years) and insignificant for older men (aged 45-60 years). The slope of age-related decline in testosterone was significant in the USA and Congolese participants, but not in the Nepalese or Paraguayan participants. CONCLUSIONS: Age patterns of testosterone decline vary between populations primarily as a result of variation in the peak levels attained in young adulthood. The potential consequences of this variation for other aspects of male health deserve investigation.
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“For example, work with Ache foragers in Paraguay has shown that levels of leptin, critical in fat sequestration, and testosterone, an anabolic hormone, are substantially lower than levels seen in U.S. adults [42], [43].”
From Hunter-gatherer energetics and human obesity (2012) · cites this paper as [43]
Citations
Cites
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.490 · Cited by 618 · cited 2×
“Reflecting these linkages to body composition, age-related declines in male testosterone are also associated with elevated risk of type II diabetes (Stellato et al., 2000; Haffner et al., 1996), coronary heart disease (Simon et al., 1997; De Pergola et al., 1997), ischemic stroke (Jeppesen et al.,…”
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Ferrini, R. L., & Barrett-Connor, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009519 · Cited by 473
Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study
Barrett-Connor, E., von Mühlen, D. G., & Kritz-Silverstein, D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5495 · Cited by 472
Effect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1966 · Cited by 460
Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359
Haffner, S. M., Shaten, J., Stem, M. P., Smith, G. D., Kuller, L., & MRFIT Research Group (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008832 · Cited by 320
Testosterone, body composition and aging.
Vermeulen, A. T., Goemaere, S., & Kaufman, J. (1999) · PubMed · Cited by 280
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Energetics and reproductive effort
Ellison, P. T. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10152 · Cited by 528
“It is interesting in this regard to note that population differences in testosterone levels are greatest among young adult males and that these differences are much less apparent with increasing age (Ellison et al., 2001).”
BackgroundSelf-citationTestosterone-mediated immune functions and male life histories
Muehlenbein, M. P., & Bribiescas, R. G. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20419 · Cited by 449
“While American males tend to exhibit a 1% decline after the age 40 (Gray et al., 1991; Harman et al., 2001), other populations are characterized by a more modest decline or no decline at all (Ellison et al., 2002).”
BackgroundHunter-gatherer energetics and human obesity
Pontzer, H., Raichlen, D. A., Wood, B. M., Mabulla, A. Z. P., Racette, S. B., & Marlowe, F. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040503 · Cited by 349
“adults [42,43].”
Evolution in Health and Disease
(2007) · doi:10.1093/acprof:oso/9780199207466.001.0001 · Cited by 323
Eisenberg, D. T. A. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21127 · Cited by 215
“Nonetheless, based upon anthropological research which implicates testosterone as a key male life history hormone involved in dominance and immune function and with varying age-related rates of decline in testosterone concentration (Bribiescas, 2001, 2006; Campbell et al., 2006; Ellison et al., 2002; Muehlenbein and B…”
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Metadata
- Authors
- Ellison, P. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ellison, P. T.
- ORCID
- Ellison, P. T.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 17
- Issue
- 12
- Pages
- 3251-3253
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2160653327
- Cited by
- 263
- References
- 38
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 15 · 2014: 9 · 2013: 4 · 2012: 19
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- salivary testosterone, age-related testosterone decline, population differences, free testosterone, bioavailable testosterone, men's health, cross-cultural comparison
- MeSH terms
- Adolescent, Adult, Aging, Congo, Humans, Male, Middle Aged, Nepal, Paraguay, Population Dynamics, Saliva, Testosterone, United States
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