The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.
Population variation in age-related decline in male salivary testosterone.
Abstract
BACKGROUND: Age-related declines in free and bioavailable testosterone are frequently reported for Western populations, but interpopulation variation in this pattern has not previously been investigated. METHODS: Salivary testosterone was measured using a consistently applied protocol on morning samples collected from men in four populations (USA, Congo, Nepal, and Paraguay) representing different geographical, ecological, and cultural settings. RESULTS: Mean testosterone levels varied significantly between the four populations. The mean testosterone differences between populations were greatest for young men (aged 15-30 years) and insignificant for older men (aged 45-60 years). The slope of age-related decline in testosterone was significant in the USA and Congolese participants, but not in the Nepalese or Paraguayan participants. CONCLUSIONS: Age patterns of testosterone decline vary between populations primarily as a result of variation in the peak levels attained in young adulthood. The potential consequences of this variation for other aspects of male health deserve investigation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, work with Ache foragers in Paraguay has shown that levels of leptin, critical in fat sequestration, and testosterone, an anabolic hormone, are substantially lower than levels seen in U.S. adults [42], [43].”
From Hunter-gatherer energetics and human obesity (2012) · cites this paper as [43]
Citations
Cites
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.490 · Cited by 618 · cited 2×
“Reflecting these linkages to body composition, age-related declines in male testosterone are also associated with elevated risk of type II diabetes (Stellato et al., 2000; Haffner et al., 1996), coronary heart disease (Simon et al., 1997; De Pergola et al., 1997), ischemic stroke (Jeppesen et al.,…”
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Ferrini, R. L., & Barrett-Connor, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009519 · Cited by 473
Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study
Barrett-Connor, E., von Mühlen, D. G., & Kritz-Silverstein, D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5495 · Cited by 472
Effect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1966 · Cited by 460
Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359
Haffner, S. M., Shaten, J., Stem, M. P., Smith, G. D., Kuller, L., & MRFIT Research Group (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008832 · Cited by 320
Testosterone, body composition and aging.
Vermeulen, A. T., Goemaere, S., & Kaufman, J. (1999) · PubMed · Cited by 280
Cited by
Sorted by citations
Energetics and reproductive effort
Ellison, P. T. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10152 · Cited by 528
“It is interesting in this regard to note that population differences in testosterone levels are greatest among young adult males and that these differences are much less apparent with increasing age (Ellison et al., 2001).”
BackgroundSelf-citationTestosterone-mediated immune functions and male life histories
Muehlenbein, M. P., & Bribiescas, R. G. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20419 · Cited by 449
“While American males tend to exhibit a 1% decline after the age 40 (Gray et al., 1991; Harman et al., 2001), other populations are characterized by a more modest decline or no decline at all (Ellison et al., 2002).”
BackgroundHunter-gatherer energetics and human obesity
Pontzer, H., Raichlen, D. A., Wood, B. M., Mabulla, A. Z. P., Racette, S. B., & Marlowe, F. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040503 · Cited by 349
“adults [42,43].”
Evolution in Health and Disease
(2007) · doi:10.1093/acprof:oso/9780199207466.001.0001 · Cited by 323
Eisenberg, D. T. A. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21127 · Cited by 215
“Nonetheless, based upon anthropological research which implicates testosterone as a key male life history hormone involved in dominance and immune function and with varying age-related rates of decline in testosterone concentration (Bribiescas, 2001, 2006; Campbell et al., 2006; Ellison et al., 2002; Muehlenbein and B…”
BackgroundTestosterone and paternal care in East African foragers and pastoralists
Muller, M. N., Marlowe, F. W., Bugumba, R., & Ellison, P. T. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2008.1028 · Cited by 190
Self-citationHuman reproduction and health: an evolutionary perspective
Jasieńska, G., Bribiescas, R. G., Furberg, A., Helle, S., & la Mora, A. N. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30573-1 · Cited by 193
Steroid analysis in saliva: an overview.
Lewis, J. G. (2006) · PubMed Central · Cited by 172
Testosterone and Sexual Desire in Healthy Women and Men
van Anders, S. M. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9946-2 · Cited by 175
Small Molecule Immunosensing Using Surface Plasmon Resonance
Mitchell, J. S. (2010) · Sensors · doi:10.3390/s100807323 · Cited by 164
“1–10 ng/mL for salivary cortisol and 29–290 pg/mL for salivary testosterone [35].”
BackgroundAlvergne, A., Faurie, C., & Michel Raymond, A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.07.013 · Cited by 161
“A first analysis was conducted to investigate the effects of age, bodymass index (BMI) and socio-economic status (SES); these were suggested to be putative confounding factors for T levels in subsistence populations (Ellison et al., 2002; Lukas et al., 2004).”
BackgroundMethodResultInfluentialNagler, R. M. (2004) · Biogerontology · doi:10.1023/b:bgen.0000038023.36727.50 · Cited by 146
“Other salivary components which were found to be reduced with age are testosterone and melatonin (Ellison et al. 2002; Zhou et al. 2003; Gooneratne et al. 2003).”
BackgroundHuman sickness behavior: Ultimate and proximate explanations
Shattuck, E. C., & Muehlenbein, M. P. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22698 · Cited by 154
“There is also substantial inter-populational variation in hormone levels (Ellison et al., 2002).”
BackgroundLiu, P. Y., Beilin, J., Meier, C., Nguyen, T. V., Center, J. R., Leedman, P. J., Seibel, M. J., Eisman, J. A., & Handelsman, D. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0862 · Cited by 142
“Furthermore, geographical differences in the age-related decline of testosterone have been reported (14), although small sample size and assessment of salivary rather than blood testosterone are important limitations.”
BackgroundTestosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk
Michaud, J. E., Billups, K. L., & Partin, A. W. (2015) · Therapeutic Advances in Urology · doi:10.1177/1756287215597633 · Cited by 143
“For instance, Ellison and colleagues demonstrated young adult elevations in testosterone and subsequent age-related declines in US and Congo populations, but not in Nepal or Paraguay [Ellison et al.”
BackgroundTestosterone and Economic Risk Taking: A Review
Apicella, C. L., Carré, J. M., & Dreber, A. (2015) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-014-0020-2 · Cited by 142
“…in the Swedish Twin Registry and found that genetic variation accounted for approximately 25 % of variation in portfolio risk. anthropology (e.g. Ellison et al. 2002), primatology (e.g. Muller and Wrangham 2004), politics (e.g. Apicella and Cesarini 2011), management (Sapienza et al. 2009) and…”
BackgroundThe Encultured Brain: An Introduction to Neuroanthropology
Lende, D. H., & Downey, G. (2012) · Project Muse (Johns Hopkins University) · Cited by 130
Testosterone related to age and life-history stages in male baboons and geladas
Beehner, J. C., Gesquiere, L. R., Seyfarth, R. M., Cheney, D. L., Alberts, S. C., & Jeanne Altmann, A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.08.005 · Cited by 125
“informative than T changes across the life span (e.g., Bribiescas, 2006; Crawford et al., 1997; Ellison et al., 2002; Martin et al., 1977).”
InfluentialWEIRD bodies: mismatch, medicine and missing diversity
Gurven, M., & Lieberman, D. E. (2020) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2020.04.001 · Cited by 130
Natri, H. M., García, A. R., Buetow, K. H., Trumble, B. C., & Wilson, M. A. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.04.008 · Cited by 118
Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment?
Hackney, A. C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00011 · Cited by 134
“Furthermore, generally resting testosterone is also lower among men in physically active non-industrial populations compared with those in less active, industrialized countries (124).”
BackgroundManuck, S. B., Marsland, A. L., Flory, J. D., Gorka, A. X., Ferrell, R. E., & Hariri, A. R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.013 · Cited by 119
Marriage, parenting, and testosterone variation among Kenyan Swahili men
Gray, P. B. (2003) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10293 · Cited by 114
Energy expenditure and activity among Hadza hunter‐gatherers
Pontzer, H., Raichlen, D. A., Wood, B. M., Thompson, M. E., Racette, S. B., Mabulla, A. Z. P., & Marlowe, F. W. (2015) · American Journal of Human Biology · doi:10.1002/ajhb.22711 · Cited by 122
“For example, Ellison et al. (2002) reported lower levels of testosterone (an anabolic hormone) among men in traditional foraging and subsistence agriculture populations compared with men in the United States.”
BackgroundFacial Width-To-Height Ratio (fWHR) Is Not Associated with Adolescent Testosterone Levels
Hodges‐Simeon, C. R., Sobraske, K. N. H., Samore, T., Gurven, M., & Gaulin, S. J. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153083 · Cited by 108
Gender differences in implicit self-esteem following a romantic partner’s success or failure.
Ratliff, K. A., & Oishi, S. (2013) · Journal of Personality and Social Psychology · doi:10.1037/a0033769 · Cited by 113
Energetics, Reproductive Ecology, and Human Evolution
Ellison, P. T. (2008) · PaleoAnthropology · Cited by 103
Self-citationEnergy Constraint as a Novel Mechanism Linking Exercise and Health
Pontzer, H. (2018) · Physiology · doi:10.1152/physiol.00027.2018 · Cited by 102
“Morning salivary testosterone is also lower among men in physically active non-industrial populations compared with those in less active, industrialized countries (21).”
BackgroundEnergy Expenditure in Humans and Other Primates: A New Synthesis
Pontzer, H. (2015) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102214-013925 · Cited by 104
“Furthermore, traditional populations vary in levels of testosterone (an anabolic hormone) (Ellison et al. 2002) and leptin (involved in fat sequestration) (Bribiescas 2001).”
BackgroundCross-cultural variation in men’s preference for sexual dimorphism in women’s faces
Marcinkowska, U. M., Kozlov, M. V., Cai, H., Contreras-Garduño, J., Dixson, B. J., Oana, G. A., Kaminski, G., Li, N. P., Lyons, M. T., Onyishi, I. E., et al. (2014) · Biology Letters · doi:10.1098/rsbl.2013.0850 · Cited by 136
“Further in nonindustrialized populations and in countries with poor health where men are exposed to more pathogens, testosterone levels are, on average, lower [28] especially among men under 45 years old [29].”
BackgroundBalancing growth, reproduction, maintenance, and activity in evolved energy economies
Pontzer, H., & McGrosky, A. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.018 · Cited by 95
Higham, J. P., Heistermann, M., & Dario Maestripieri, A. (2012) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-012-1420-6 · Cited by 87
“We predicted that older adult males would exhibit reduced androgen levels, consistent with data from humans (Ellison et al. 2002; Bribiescas 2006), chacma baboons and gelada (Beehner et al.”
BackgroundResultMitchell, J. S., & Lowe, T. E. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.11.018 · Cited by 84
“Testosterone has a physiological range in human adult male aliva of 29–290 pg ml−1 (Ellison et al., 2002) and so a highly sensiive SPR system would be required to measure it.”
BackgroundMethodTrumble, B. C., Cummings, D. K., Rueden, C. R. V., O’Connor, K. A., Smith, E. A., Gurven, M., & Kaplan, H. S. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.0455 · Cited by 80
Male Life History, Reproductive Effort, and the Evolution of the GenusHomo
Bribiescas, R. G., Ellison, P. T., & Gray, P. B. (2012) · Current Anthropology · doi:10.1086/667538 · Cited by 80
Self-citationOn the evolution, life history, and proximate mechanisms of human male reproductive senescence
Bribiescas, R. G. (2006) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20087 · Cited by 77
Measurement of Testosterone in Human Sexuality Research: Methodological Considerations
van Anders, S. M., Goldey, K. L., & Bell, S. N. (2013) · Archives of Sexual Behavior · doi:10.1007/s10508-013-0123-z · Cited by 83
The evolution and expression of virulence
Ebert, D., & Bull, J. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0012 · Cited by 75
Lieberman, D. E., Kistner, T. M., Richard, D. J., Lee, I.-M. M., & Baggish, A. L. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107621118 · Cited by 82
Pollet, T. V., van der Meij, L., Cobey, K. D., & Buunk, A. P. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.03.005 · Cited by 76
“In addition, it is possible that cross-cultural variation in the age dependent decline of T (Ellison et al., 2002) may explain why the effect of T is positively related to opposite sex partners in our sample of elderly American men but negatively in the older sample used by Alvergne et al. (2009).”
Reproduction and Aging in Marmosets and Tamarins
Tardif, S. D., Araújo, A., Arruda, M. F., French, J. A., de Sousa, M. B. C., & Yamamoto, M. E. (2008) · KARGER eBooks · doi:10.1159/000137678 · Cited by 70
Madrigal, L. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9781139171113 · Cited by 70
Schooling, C. M., & Leung, G. M. (2010) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.086553 · Cited by 66
“Similarly, hormone levels appear to increase with epidemiological time.”
BackgroundEvolutionary contributions to the study of human fertility
Sear, R. (2015) · Population studies · doi:10.1080/00324728.2014.982905 · Cited by 55
“Hormonal assays Multi-country study (USA, Congo, Nepal, Paraguay) Ellison et al. (2002) Are breast-feeding practices or maternal energy budget stronger correlates of the resumption of postpartum fecundity?”
BackgroundTrumble, B. C., Blackwell, A. D., Stieglitz, J., Thompson, M. E., Suarez, I. M., Kaplan, H. S., & Gurven, M. (2016) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23054 · Cited by 66
“Additionally, industrialized populations have significantly higher levels of testosterone at younger ages compared with subsistence populations, and steeper age-related declines (Ellison et al., 2002; Trumble et al., 2012).”
BackgroundSalivary testosterone and body composition among Ariaal males
Campbell, B., O'Rourke, M. T., & Lipson, S. F. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10203 · Cited by 62
“In addition, based on earlier results linking maximum testosterone values and age-related declines in T (Ellison et al., 2002), we expect the settled group to show a more pronounced agerelated decline in salivary T.”
BackgroundGoldstein, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014826 · Cited by 68
“[31].”
Salivary Sex Hormone Measurement in a National, Population-Based Study of Older Adults
Gavrilova, N. S., & Lindau, S. T. (2009) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbn028 · Cited by 61
Testosterone and Marriage among Ariaal Men of Northern Kenya
Gray, P. B., Ellison, P. T., & Campbell, B. (2007) · Current Anthropology · doi:10.1086/522061 · Cited by 58
“Age-related declines in testosterone levels have been almost universally observed, though population differences exist in the rate of decline—the slope being steepest among developed, Western populations and nonsignificant among some traditional, non-Western populations (Ellison et al. 2002).”
BackgroundSelf-citationBribiescas, R. G. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20079 · Cited by 58
Validation of salivary testosterone as a screening test for male hypogonadism
Morley, J. E., Perry, H. M., Patrick, P., Dollbaum, C. M., & Kells, J. (2006) · The Aging Male · doi:10.1080/13685530600907993 · Cited by 56
“Previously, some small studies have demonstrated a decline in ST with aging [48,49,50].”
Testosterone and disinhibited personality in healthy males
Aluja, A., Garcı́a, L. F., Garcı́a, Ó., & Blanco, E. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.06.007 · Cited by 53
DuBois, L. Z., Gibb, J. K., Juster, R., & Powers, S. I. (2020) · American Journal of Human Biology · doi:10.1002/ajhb.23555 · Cited by 57
“…hormonal sex, ” such as variation in testosterone levels in response to relational (Gettler, McDade, Feranil, & Kuzawa, 2011; Kuzawa, Gettler, Huang, & McDade, 2010; van Anders, Hamilton, & Watson, 2007) and socioecological factors (Bribiescas, 1996; Bribiescas & Hill, 2010; Ellison et al., 2002).”
The low male voice is a costly signal of phenotypic quality among Bolivian adolescents
Hodges‐Simeon, C. R., Gurven, M., & Gaulin, S. J. C. (2015) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2015.01.002 · Cited by 53
“These results accord with findings from previous studies demonstrating that both chronic (Ellison et al., 2002) and acute (Friedl et al.”
ResultTrumble, B. C., Cummings, D. K., O’Connor, K. A., Holman, D. J., Smith, E. A., Kaplan, H. S., & Gurven, M. (2013) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2013.06.002 · Cited by 53
“, 2009; Worthman & Konner, 1987), as well a slower and shallower rate of change with age (Ellison et al., 2002), or no association between testosterone and age (Bribiescas, 1996; Trumble et al.”
BackgroundResultInfluentialMadmen: An Evolutionary Perspective on Anger and Men’s Violent Responses to Transgression
Fessler, D. M. T. (2009) · Springer eBooks · doi:10.1007/978-0-387-89676-2_21 · Cited by 55
“…age (Harman, Metter, Tobin, Pearson, & Blackman, 2001; Feldman et al., 2002), although there are substantial cross-population differences in the rate of decline, possibly due in part to dietary factors (Ellison & Panter-Brick, 1996; Ellison et al., 1998, 2002; Campbell, Leslie, & Campbell, 2006).”
BackgroundWestern Diseases: An Evolutionary Perspective
Pollard, T. M. (2008) · Durham Research Online (Durham University) · Cited by 48
An Assessment of the Breeding Maturity of Insemination Boars Based on Ejaculate Quality Changes
Banaszewska, D., & Kondracki, S. (2012) · Folia Biologica · doi:10.3409/fb60_34.151162 · Cited by 48
The crown joules: energetics, ecology, and evolution in humans and other primates
Pontzer, H. (2017) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21513 · Cited by 50
“For example, Ellison et al., 2002 have shown suppressive effects of physical activity on reproductive hormone levels in both men (testosterone) and women (estrogen) (Ellison & Lager, 1986; Ellison, et al., 1993).”
BackgroundPathogen evolution in a vaccinated world
Read, A. F., & Mackinnon, M. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0011 · Cited by 45
Low Testosterone Correlates with Delayed Development in Male Orangutans
Thompson, M. E., Zhou, A., & Knott, C. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047282 · Cited by 45
“Age declines in testosterone are detectable in some human populations [31], as well as some non-human primates (e.”
BackgroundGray, P. B., Straftis, A. A., Bird, B. M., McHale, T. S., & Zilioli, S. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.017 · Cited by 45
The ecology and evolution of antibiotic-resistant bacteria
Bergstrom, C. T., & Feldgarden, M. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0010 · Cited by 44
Kobori, Y., Koh, E., Sugimoto, K., Izumi, K., Narimoto, K., Maeda, Y., Konaka, H., Mizokami, A., Matsushita, T., Iwamoto, T., et al. (2009) · International Journal of Impotence Research · doi:10.1038/ijir.2009.14 · Cited by 40
Muehlenbein, M. P. (2006) · Biodemography and Social Biology · doi:10.1080/19485565.2006.9989113 · Cited by 40
Age related variation of salivary testosterone values in healthy Japanese males
Uchida, A., Bribiescas, R. G., Ellison, P. T., Kanamori, M., Ando, J., Hirose, N., & Ono, Y. (2006) · The Aging Male · doi:10.1080/13685530601060461 · Cited by 39
“These results suggest that the commonly reported decline of testosterone values after the third decade of life observed in western countries may not be caused by aging per se. Instead, any association between testosterone and age may be a result of various factors, including energy availability and utilization during…”
BackgroundInfluentialSelf-citationCorrelates of testosterone change as men age
Kanabar, R., Mazur, A., Plum, A., & Schmied, J. (2022) · The Aging Male · doi:10.1080/13685538.2021.2023493 · Cited by 38
Is There a Testosterone Awakening Response in Humans?
Kuzawa, C. W., Georgiev, A. V., McDade, T. W., Bechayda, S. A., & Gettler, L. T. (2015) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-015-0038-0 · Cited by 39
“Thus, although past studies point to a relatively abrupt post-waking decline in salivary T, many questions remain unresolved, includingwhether themagnitude of this change varies by age or due to factors like social-behavioral regulation, as exemplified by fatherhood or pairbonding status (Bribiescas and Hill 2010; Ell…”
BackgroundTestosterone, physical activity, and somatic outcomes among Filipino males
Gettler, L. T., Agustin, S. S., & Kuzawa, C. W. (2010) · American Journal of Physical Anthropology · doi:10.1002/ajpa.21282 · Cited by 37
Alvarado, L. C. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21016 · Cited by 37
“VC 2010 Wiley-Liss, Inc. in testosterone levels between these groups is primarily among young men (Bribiescas, 2001; Ellison et al., 2002; Kehinde et al., 2006).”
BackgroundAndrogen receptor CAG repeats and body composition among Ariaal men
Campbell, B., Gray, P. B., Eisenberg, D. T. A., Ellison, P. T., & Sorenson, M. D. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00825.x · Cited by 37
“Testosterone levels among men vary across populations, with subsistence populations showing lower levels relative to industrialized populations (Ellison et al. 2002).”
BackgroundSelf-citationAn evolutionary and life history perspective on human male reproductive senescence
Bribiescas, R. G. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05524.x · Cited by 36
How hormones mediate trade-offs in human health and disease
Bribiescas, R. G., & Ellison, P. T. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0007 · Cited by 36
Self-citationHadza hunter‐gatherer men do not have more masculine digit ratios (2 D :4 D )
Apicella, C. L., Tobolsky, V. A., Marlowe, F. W., & Miller, K. W. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22864 · Cited by 36
Patterns and processes of human life history evolution
Muehlenbein, M. P., & Flinn, M. V. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199568765.003.0012 · Cited by 37
Hormones and Reproductive Cycles in Primates
Wendy Saltzman, A., Tardif, S. D., & Rutherford, J. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374928-4.10013-6 · Cited by 33
Centennial perspective on human adaptability
Leonard, W. R. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23401 · Cited by 34
“…have higher circulating testosterone levels and greater muscle mass than their counterparts among more traditional societies of the developing world (Bribiescas, 1996, 2001; Ellison et al., 2002; Campbell, Leslie, Little, & Campbell, 2005; Gettler, Agustin, & Kuzawa, 2010; Trumble et al., 2012).”
BackgroundNyberg, C. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.002 · Cited by 33
“, 2004; Ice, 2005), although age-related declines in other endocrine hormones have been reported among some nonwestern populations (Ellison, 2010; Ellison et al., 2002; Campbell et al., 2006).”
BackgroundResultSeasonal and circadian variation in salivary testosterone in rural Bolivian men
Vitzthum, V. J., Worthman, C. M., Beall, C. M., Thornburg, J., Vargas, E., Villena, M., Soria, R., Cáceres, E., & Hilde Spielvogel, E. (2009) · American Journal of Human Biology · doi:10.1002/ajhb.20927 · Cited by 31
“Little is known of circadian variation in T among community-dwelling men in non-industrialized settings, and the scant data on age-related variation suggests significant inter-populational variation for unknown reasons (Ellison et al. 2002).”
Alvarado, L. C., Muller, M. N., Thompson, M. E., Klimek, M., Nenko, I., & Jasieńska, G. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22771 · Cited by 31
Circadian variation in salivary testosterone across age classes in Ache Amerindian males of Paraguay
Bribiescas, R. G., & Hill, K. R. (2009) · American Journal of Human Biology · doi:10.1002/ajhb.21012 · Cited by 30
Testosterone, aging, and body composition in men from Harare, Zimbabwe
Lukas, W. D., Campbell, B., & Ellison, P. T. (2004) · American Journal of Human Biology · doi:10.1002/ajhb.20083 · Cited by 31
“Agerelated differences in salivary T across subsistence populations are most apparent among males age 20–30 (Ellison et al., 2002), suggesting that population differences in salivary T may be more closely tied to the attainment of adult body size, rather than to energetic conditions during…”
BackgroundResultInfluentialSelf-citationYasuda, M., Honma, S., Furuya, K., Yoshii, T., Kamiyama, Y., Ide, H., Muto, S., & Horie, S. (2008) · Journal of Men s Health · doi:10.1016/j.jomh.2007.12.004 · Cited by 30
Predictors of South African male testosterone levels: the THUSA study
Gray, P. B., Kruger, A., Huisman, H. W., Wissing, M. P., & Vorster, H. H. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20471 · Cited by 29
“Cross-sectional data reveal age-related declines in men from Zimbabwe (Lukas et al., 2004) and rural Kenya (Campbell et al., 2003), although population variation in this age-related testosterone decline has been observed (Ellison et al., 2002).”
BackgroundMitchell, J. S., & Lowe, T. E. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.07.012 · Cited by 28
Ultradian rhythmicity and induced changes in salivary testosterone
Beaven, C. M., Ingram, J. R., Gill, N. D., & Hopkins, W. G. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1518-3 · Cited by 29
“Age-related decreases in testosterone concentrations are commonly reported and have been associated with changes in fat mass, muscle mass, and bone density (Nahoul and Roger 1990; Ellison et al. 2002; Kaufman and Vermeulen 2005).”
BackgroundAjo, R., Segura, A., Mira, L., Inda, M., Alfayate, R., Sánchez-Barbie, Á., Margarit, C., & Peiró, A. M. (2016) · The Aging Male · doi:10.1080/13685538.2016.1185408 · Cited by 27
Vongas, J. G., & Hajj, R. A. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.04.005 · Cited by 26
Magid, K. S., Chatterton, R. T., Ahamed, F. U., & Bentley, G. R. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0567-6 · Cited by 25
Trumble, B. C., Stieglitz, J., Rodriguez, D. E., Linares, E. C., Kaplan, H. S., & Gurven, M. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv051 · Cited by 27
“These populations show lower levels of testosterone across all adult ages as compared with men in industrialized nations (23–25), as well as slower and shallower rate of decline with age (23), or no association between testosterone and age (25).”
BackgroundEvolution, developmental plasticity, and metabolic disease
Kuzawa, C. W., Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0019 · Cited by 27
Wentzell, E. (2017) · The Journal of Sex Research · doi:10.1080/00224499.2016.1259386 · Cited by 26
Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks
Leonard, W. R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0020 · Cited by 26
Country and Sex Differences in Decision Making Under Uncertainty and Risk
Singh, V., Schiebener, J., Müller, S. M., Liebherr, M., Brand, M., & Buelow, M. T. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00486 · Cited by 26
Late-onset hypogonadism: Clinical evidence, biological aspects and evolutionary considerations
Jaschke, N., Wang, A., Hofbauer, L. C., Rauner, M., & Rachner, T. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101301 · Cited by 30
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118 · Cited by 25
The endocrine pharmacology of testosterone therapy in men
Oettel, M. (2004) · Die Naturwissenschaften · doi:10.1007/s00114-003-0494-4 · Cited by 25
“It may even be possible to use T measurement in the saliva as a good screening test for hypogonadism in the future (Granger et al. 1999; Van Honk et al. 1999; Ellison et al. 2002; Krause et al. 2002; Shirtcliff et al. 2002).”
BackgroundIs Rising Obesity Causing a Secular (Age-Independent) Decline in Testosterone among American Men?
Mazur, A., Westerman, R., & Mueller, U. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076178 · Cited by 23
“Anthropologists report that this agerelated decline in T is less or nonexistent among nonindustrial communities [14–16].”
BackgroundHormones, age, and sex affect platelet responsiveness in vitro
Hadley, J. B., Kelher, M. R., Coleman, J. R., Kelly, K. K., Dumont, L. J., Esparza, O., Banerjee, A. M., Cohen, M. J. M., Jones, K. L., & Silliman, C. C. (2022) · Transfusion · doi:10.1111/trf.17054 · Cited by 24
Urlacher, S. S., Kim, E. Y., Luan, T., Young, L. J., & Adjetey, B. (2022) · American Journal of Human Biology · doi:10.1002/ajhb.23811 · Cited by 23
“…1991; Ellison et al., 1989; Gray et al., 2007), South America (e.g., Beall et al., 1992; Bribiescas, 1996; Trumble et al., 2012), Asia (e.g., Ellison et al., 2002; Ellison & Panter-Brick, 1996), and Oceania (e.g., Campbell, 1994), while exhibiting between-group variation (Alvarado et al.,…”
Background
Metadata
- Authors
- Ellison, P. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ellison, P. T.
- ORCID
- Ellison, P. T.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 17
- Issue
- 12
- Pages
- 3251-3253
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2160653327
- Cited by
- 263
- References
- 38
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 15 · 2014: 9 · 2013: 4 · 2012: 19
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- salivary testosterone, age-related testosterone decline, population differences, free testosterone, bioavailable testosterone, men's health, cross-cultural comparison
- MeSH terms
- Adolescent, Adult, Aging, Congo, Humans, Male, Middle Aged, Nepal, Paraguay, Population Dynamics, Saliva, Testosterone, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
