Inflammatory profiles and clinical features of coronavirus 2019 survivors 3 months after discharge in Wuhan, China.
Open accessAbstract
Background: Postdischarge immunity and its correlation with clinical features among patients recovered from coronavirus disease 2019(COVID-19) are poorly described. This prospective cross-sectional study explored the inflammatory profiles and clinical recovery of patients with COVID-19 at 3 months after hospital discharge. Methods: Patients with COVID-19 discharged from 4 hospitals in Wuhan, recovered asymptomatic patients (APs) from an isolation hotel, and uninfected healthy controls (HCs) were recruited. Viral nucleic acid and antibody detection, laboratory examination, computed tomography, pulmonary function assessment, multiplex cytokine assay, and flow cytometry were performed. Results: The72 age-, sex- and body mass index–matched participants included 19 patients with severe/critical COVID-19 (SPs), 20 patients with mild/moderate COVID-19 (MPs), 16 APs, and 17 HCs. At 3 months after discharge, levels of proinflammatory cytokines and factors related to vascular injury/repair in patients recovered from COVID-19 had not returned to those of the HCs, especially among recovered SPs compared with recovered MPs and APs. These cytokines were significantly correlated with impaired pulmonary function and chest computed tomographic abnormalities. However, levels of immune cells had returned to nearly normal levels and were not significantly correlated with abnormal clinical features. Conclusion: Vascular injury, inflammation, and chemotaxis persisted in patients with COVID-19 and were correlated with abnormal clinical features 3 months after discharge, especially in recovered SPs.
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Long-lasting hypoxia may contribute substantially to postinfection cognitive decline.
“long-lasting hypoxia may also contribute substantially to postinfection cognitive decline”
From One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study (2022) · cites this paper as [32]
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- Authors
- Zhou, M., Yin, Z., Xu, J., Wang, S., Liao, T., Wang, K., Li, Y., Yang, F., Wang, Z., Yang, G., Zhang, J., & Jin, Y.
- Affiliations
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-04-04
- Volume
- 224
- Issue
- 9
- Pages
- 1473-1488
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC8083630
- OpenAlex
- W3147374446
- Cited by
- 39
- References
- 29
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 11 · 2022: 15 · 2021: 7
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82041018)
- National Major Science and Technology Projects of China (2019ZX09301001)
- Ministry of Science and Technology of the People's Republic of China (2020YFC0844300)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, inflammatory cytokines, vascular injury, lung function, chest CT abnormalities, long-term clinical outcomes
- MeSH terms
- COVID-19, SARS-CoV-2, Aftercare, Anti-Bacterial Agents, Antiviral Agents, China, Cross-Sectional Studies, Humans, Patient Discharge, Prospective Studies, Retrospective Studies, Cytokines, Treatment Outcome, Survivors, Vascular System Injuries
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