Toll-like receptors in innate immunity

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 12×

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022

Innate Immune Responses to Dengue Virus

Navarro-Sánchez, E., Desprès, P., & Cedillo‐Barrón, L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.04.007 · Cited by 140

Cytokines and the neurodevelopmental basis of mental illness

Ratnayake, U., Quinn, T., Walker, D. W., & Dickinson, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00180 · Cited by 141

The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA

Ha, S., Kim, D., Hwang, H., Rich, A., Kim, Y.-G., & Kim, K. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0810463106 · Cited by 133

Chemokine Regulation of Neutrophil Infiltration of Skin Wounds

Su, Y., & Richmond, A. J. (2014) · Advances in Wound Care · doi:10.1089/wound.2014.0559 · Cited by 144

Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine

Goyette, P., Labbé, C., Trinh, T. T., Xavier, R. J., & Rioux, J. D. (2007) · Annals of Medicine · doi:10.1080/07853890701197615 · Cited by 141

Antibody-drug conjugates in lung cancer: dawn of a new era?

Coleman, N., Yap, T. A., Heymach, J. V., Meric‐Bernstam, F., & Le, X. (2023) · npj Precision Oncology · doi:10.1038/s41698-022-00338-9 · Cited by 145

Estradiol Regulates Expression of Estrogen Receptor ERα46 in Human Macrophages

Murphy, A. J., Guyre, P. M., Wira, C. R., & Pioli, P. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005539 · Cited by 145

TLR4, Ethanol, and Lipid Rafts: A New Mechanism of Ethanol Action with Implications for other Receptor-Mediated Effects

Szabó, G., Dolganiuc, A., Dai, Q., & Pruett, S. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1243 · Cited by 137

Non‐genetic risk factors and the development of inhibitors in haemophilia: a comprehensive review and consensus report

Astermark, J., Altisent, C., Bátorová, A., Diniz, M. J., Gringeri, A., Holme, P. A., Karafoulidou, A., Fernández, M. F. L., Reipert, B. M., Rocino, A., et al. (2010) · Haemophilia · doi:10.1111/j.1365-2516.2010.02231.x · Cited by 137

Toll-Like Receptor Signaling and Liver Fibrosis

Aoyama, T., Paik, Y., & Seki, E. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/192543 · Cited by 146

Estrogen regulation of gene expression in the teleost fish immune system

Burgos-Aceves, M. A., Cohen, A., Smith, Y., & Faggio, C. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.09.006 · Cited by 138

Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease

Medvedev, A. E., Sabroe, I., Hasday, J. D., & Vogel, S. N. (2006) · Journal of Endotoxin Research · doi:10.1177/09680519060120030201 · Cited by 210

Development of immunity in early life

Goenka, A., & Kollmann, T. R. (2015) · Journal of Infection · doi:10.1016/j.jinf.2015.04.027 · Cited by 144

Peptidoglycan from lactobacilli inhibits interleukin‐12 production by macrophages induced by Lactobacillus casei through Toll‐like receptor 2‐dependent and independent mechanisms

Shida, K., Kiyoshima‐Shibata, J., Kaji, R., Nagaoka, M., & Nanno, M. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03095.x · Cited by 136

Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling

Jedinak, A., Dudhgaonkar, S. P., Wu, Q., Simon, J., & Slíva, D. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-52 · Cited by 136

Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans

Frasca, D., Riley, R. L., & Blomberg, B. B. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.005 · Cited by 136

Of mice and man: TLR11 (finally) finds profilin

Lauw, F. N., Caffrey, D. R., & Golenbock, D. T. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.08.006 · Cited by 136

Biochemical regulation of the inflammasome

Dowling, J. K., & O'Neill, L. A. J. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.694844 · Cited by 139

Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4+ T Cell Response

Yarovinsky, F., Kanzler, H., Hieny, S. E., Coffman, R. L., & Sher, A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.015 · Cited by 135

Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses

Huang, X., & Yang, Y. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501333 · Cited by 121

Toll-like receptors in cerebral ischemic inflammatory injury

Wang, Y., Lin, S., & Yang, Q. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-134 · Cited by 134

Function and 3D Structure of the N-Glycans on Glycoproteins

Nagae, M., & Yamaguchi, Y. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078398 · Cited by 134

Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogen and Its Receptors in Cancer Physiopathology

Mendoza, M. S., & Morales‐Montor, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00348 · Cited by 133

Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections

Gauthier, T., & Chen, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.780839 · Cited by 137

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion

Sanjuán, M. A. F., Rao, N. L., Lai, K.-T. A., Gu, Y., Sun, S., Fuchs, A. G., Fung‐Leung, W., Colonna, M., & Karlsson, L. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508058 · Cited by 132

Toll-like receptors and their dual role in periodontitis: a review

Hans, M., & Hans, V. M. (2011) · Journal of Oral Science · doi:10.2334/josnusd.53.263 · Cited by 136

Sphingolipid metabolism during Toll‐like receptor 4 (TLR4)‐mediated macrophage activation

Olona, A., Hateley, C., Muralidharan, S., Wenk, M. R., Torta, F. T., & Behmoaras, J. V. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15642 · Cited by 134

Roles of TLR2, TLR4, NOD2, and NOD1 in Pulp Fibroblasts

Hirao, K., Yumoto, H., Takahashi, K., Mukai, K., Nakanishi, T., & Matsuo, T. (2009) · Journal of Dental Research · doi:10.1177/0022034509341779 · Cited by 130

Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells

Sun, D., Chen, S., Cheng, A., & Wang, M. (2016) · Viruses · doi:10.3390/v8030082 · Cited by 135

Characteristic and Functional Analysis of Toll-like Receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, Reveals Ancient Origin of TLR-Mediated Innate Immunity

Zhang, Y., He, X., Feng, Y. Y., Xiang, Z., Li, J., Thorpe, K. L., & Yu, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076464 · Cited by 129

Toll‐Like Receptors in Older Adults

van Duin, D., & Shaw, A. C. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01300.x · Cited by 131

Antibiotic-Induced Depletion of Murine Microbiota Induces Mild Inflammation and Changes in Toll-Like Receptor Patterns and Intestinal Motility

Grasa, L., Abecia, L., Forcén, R., Castro, M., de Jalón, J. A. G., Latorre, E., Alcalde, A. I., & Murillo, M. D. (2015) · Microbial Ecology · doi:10.1007/s00248-015-0613-8 · Cited by 128

LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages

Kong, X., Yan, H., Chen, L., Dong, L., Yang, W., Liu, Q., Yu, L., Huang, D., Liu, S., Liu, H., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062611 · Cited by 134

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

Garcia‐Ortíz, H., Velázquez‐Cruz, R., Espinosa-Rosales, F. J., Jiménez‐Morales, S., Baca, V., & Orozco, L. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124313 · Cited by 129

Macrophages and cytokines in the early defence against herpes simplex virus

Ellermann‐Eriksen, S. (2005) · Virology Journal · doi:10.1186/1743-422x-2-59 · Cited by 134

Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Reber, A. J., Chirkova, T., Kim, J. H., Cao, W., Biber, R., Shay, D. K., & Sambhara, S. R. (2012) · Europe PMC (PubMed Central) · Cited by 133

Endothelial cell toll‐like receptor 4 regulates fibrosis‐associated angiogenesis in the liver†

Jagavelu, K., Routray, C., Shergill, U., O’Hara, S. P., Faubion, W., & Shah, V. H. (2010) · Hepatology · doi:10.1002/hep.23739 · Cited by 130

Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

Kim, D., Lillehoj, H. S., Lee, S. H., Lillehoj, E. P., & Bravo, D. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000530 · Cited by 128

Lipoteichoic acids as a major virulence factor causing inflammatory responses via Toll-like receptor 2

Kang, S., Sim, J., Yun, C., & Han, S. H. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0804-y · Cited by 130

Sertoli Cells Initiate Testicular Innate Immune Responses through TLR Activation

Anna Riccioli, A., Starace, D., Galli, R., Fuso, A., Scarpa, S., Palombi, F., Cesaris, P. D., Elio Ziparo, A., & Filippini, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7122 · Cited by 127

Cutaneous Granulomatosis: a Comprehensive Review

Terziroli Beretta-Piccoli, B., Mainetti, C., Peeters, M.-A., & Laffitte, E. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8666-8 · Cited by 124

REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids

Khan, K. N., Kitajima, M., Hiraki, K., Fujishita, A., Sekine, I., Ishimaru, T., & Masuzaki, H. (2008) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00643.x · Cited by 125

Toll-Like Receptors in Atherosclerosis

Falck-Hansen, M., Kassiteridi, C., & Monaco, C. G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714008 · Cited by 128

Inhibition of RNA-binding proteins with small molecules

Wu, P. (2020) · Nature Reviews Chemistry · doi:10.1038/s41570-020-0201-4 · Cited by 130

The impact of endogenous triggers on trauma-associated inflammation

Zedler, S., & Faist, E. (2006) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3280106806 · Cited by 125

Structural and Functional Analyses of the Human Toll-like Receptor 3

Sun, J., Duffy, K. E., Ranjith-Kumar, C. T., Xiong, J., Lamb, R. J., Santos, J., Hema, M., Cunningham, M., Holzenburg, A., Sarisky, R. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510442200 · Cited by 125

Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis

Heinsbroek, S. E. M., Taylor, P. R., Martínez, F. O., Martínez‐Pomares, L., Brown, G. D., & Gordon, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000218 · Cited by 127

Novel roles for α-crystallins in retinal function and disease

Kannan, R., Sreekumar, P. G., & Hinton, D. R. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.001 · Cited by 127

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice

Kim, S.-J., Choi, Y., Choi, Y., & Park, T. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.012 · Cited by 133

Thermally Induced Conformation Transition of Triple-Helical Lentinan in NaCl Aqueous Solution

Wang, X., Xu, X., & Zhang, L. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp802174v · Cited by 123

β-1,3-Glucan polysaccharides as novel one-dimensional hosts for DNA/RNA, conjugated polymers and nanoparticles

Sakurai, K., Uezu, K., Numata, M., Hasegawa, T., Li, C., Kaneko, K., & Shinkai, S. (2005) · Chemical Communications · doi:10.1039/b506673p · Cited by 124

Ways to minimize bacterial infections, with special reference to Escherichia coli, to cope with the first-week mortality in chicks: an updated overview

Swelum, A. A., Elbestawy, A. R., El‐Saadony, M. T., Hussein, E. O., Alhotan, R. A., Suliman, G. M., Taha, A. E.-S., Ba-Awadh, H. A., El-Tarabily, K. A., & El-Hack, M. E. A. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101039 · Cited by 133

Molecular cloning and characterization of Toll-like receptor 9 in Japanese flounder, Paralichthys olivaceus

Takano, T., Kondo, H., Hırono, I., Endo, M., Saito‐Taki, T., & Aoki, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.018 · Cited by 122

Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes

Ikeda, F., Hecker, C., Rozenknop, A., Nordmeier, R. D., Rogov, V. V., Hofmann, K., Akira, S., Dötsch, V., & Đikić, I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601773 · Cited by 127

Toll‐like receptor interactions: tolerance of MyD88‐dependent cytokines but enhancement of MyD88‐independent interferon‐β production

Broad, A., Kirby, J. A., & Jones, D. E. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02485.x · Cited by 122

Toll-Like Receptor 4

Flynn, M. G., & McFarlin, B. K. (2006) · Exercise and Sport Sciences Reviews · doi:10.1249/01.jes.0000240027.22749.14 · Cited by 121

The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword

Redgrove, K. A., & McLaughlin, E. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00534 · Cited by 132

Sensing of M ycobacterium tuberculosis and consequences to both host and bacillus

Stamm, C. E., Collins, A. C., & Shiloh, M. U. (2015) · Immunological Reviews · doi:10.1111/imr.12263 · Cited by 131

Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

Lei, X., Xiao, X., & Wang, J. (2016) · Viruses · doi:10.3390/v8010022 · Cited by 120

Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

Cekaite, L., Furset, G., Hovig, E. J., & Sioud, M. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.09.034 · Cited by 120

A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni

Zilbauer, M., Dorrell, N., Elmi, A., Lindley, K. J., Schüller, S., Jones, H. E., Klein, N. J., Núñez, G., Wren, B. W., & Bajaj‐Elliott, M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00969.x · Cited by 120

The Arabidopsis thaliana TIR‐NB‐LRR R‐protein, RPP1A; protein localization and constitutive activation of defence by truncated alleles in tobacco and Arabidopsis

Weaver, L. M., Swiderski, M. R., Li, Y., & Jones, J. D. G. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02834.x · Cited by 121

Targeting dendritic cell signaling to regulate the response to immunization

Escors, D., Lopes, L., Lin, R., Hiscott, J., Akira, S., Davis, R. J., & Collins, M. K. (2008) · Blood · doi:10.1182/blood-2007-11-122408 · Cited by 116

Impaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases

Massier, L., Blüher, M., Kovacs, P. L., & Chakaroun, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.616506 · Cited by 130

Inflammatory Mechanisms of Diabetes and Its Vascular Complications

Nedosugova, L. V., Markina, Y. V., Бочкарева, Л. А., Кузина, И. А., Petunina, N. A., Yudina, I. Y., & Kirichenko, T. V. (2022) · Biomedicines · doi:10.3390/biomedicines10051168 · Cited by 135

Chapter 6 Interleukin 5 in the Link Between the Innate and Acquired Immune Response

Takatsu, K., Kouro, T., & Nagai, Y. (2009) · Advances in immunology · doi:10.1016/s0065-2776(08)01006-7 · Cited by 123

LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NF-κB and BMP/Smad Signaling

Huang, R., Yuan, Y., Zou, G.-M., Liu, G., Tu, J., & Li, Q. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0345 · Cited by 119

Intraspecific competition between co‐infecting parasite strains enhances host survival in African trypanosomes

Balmer, O., Stearns, S. C., Schötzau, A., & Brun, R. (2009) · Ecology · doi:10.1890/08-2291.1 · Cited by 118

Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa β and toll-like receptor pathways

Liu, S., Shi, W. M., Guo, C., Zhao, X., Han, Y., Peng, C., Chai, X., & Liu, G. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.04.030 · Cited by 119

The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes

Wang, Y., Zhong, J., Zhang, X., Liu, Z., Yang, Y., Gong, Q., & Ren, B. (2016) · Journal of Diabetes Research · doi:10.1155/2016/2543268 · Cited by 124

Respiratory Tract Dysbiosis Is Associated with Worse Outcomes in Mechanically Ventilated Patients

Kitsios, G. D., Yang, H., Yang, L., Qin, S., Fitch, A. C., Wang, X., Fair, K., Evankovich, J. W., Bain, W., Shah, F. A., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201912-2441oc · Cited by 120

Human lactoferrin activates NF‐κB through the Toll‐like receptor 4 pathway while it interferes with the lipopolysaccharide‐stimulated TLR4 signaling

Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., et al. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07620.x · Cited by 120

Mesenchymal Stem Cell Therapy for Cardiac Inflammation: Immunomodulatory Properties and the Influence of Toll-Like Receptors

van den Akker, F., de Jager, S. C. A., & Sluijter, J. P. G. (2013) · Mediators of Inflammation · doi:10.1155/2013/181020 · Cited by 118

EBV Latent Membrane Protein 1 Is a Negative Regulator of TLR9

Fathallah, I., Parroche, P., Gruffat, H., Zannetti, C., Johansson, H., Yue, J., Manet, É., Tommasino, M., Sylla, B. S., & Hasan, U. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903459 · Cited by 118

TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis

Loos, T., Dekeyzer, L., Struyf, S., Schutyser, E., Gijsbers, K., Gouwy, M., Fraeyman, A., Put, W., Ronsse, I., Grillet, B. A. M., et al. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700453 · Cited by 116

Antimicrobial Activities of Tea Polyphenol on Phytopathogens: A Review

Yang, Y., & Zhang, T. (2019) · Molecules · doi:10.3390/molecules24040816 · Cited by 117

TLR2, TLR4, CD14, CD11B, AND CD11C EXPRESSIONS ON MONOCYTES SURFACE AND CYTOKINE PRODUCTION IN PATIENTS WITH SEPSIS, SEVERE SEPSIS, AND SEPTIC SHOCK

Brunialti, M. K. C., Martins, P. S., Carvalho, H. B., Machado, F. R., Barbosa, L. M., & Salomão, R. (2006) · Shock · doi:10.1097/01.shk.0000217815.57727.29 · Cited by 117

The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti-Inflammatory Response, and Regulatory T Cells

Lewis, D. H., Chan, D. L., Pinheiro, D., Armitage‐Chan, E. A., & Garden, O. A. (2012) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2012.00905.x · Cited by 125

Microbiota regulates the TLR7 signaling pathway against respiratory tract influenza A virus infection

Wu, S., Jiang, Z.-Y., Sun, Y.-F., Yu, B., Chen, J., Dai, C.-Q., Wu, X.-L., Tang, X.-L., & Chen, X.-Y. (2013) · Current Microbiology · doi:10.1007/s00284-013-0380-z · Cited by 116

Alcohol Abuse: Critical Pathophysiological Processes and Contribution to Disease Burden

Molina, P. E., Gardner, J. D., Souza‐Smith, F. M., & Whitaker, A. M. (2014) · Physiology · doi:10.1152/physiol.00055.2013 · Cited by 120

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1

Bui, F. Q., Johnson, L., Roberts, J. S., Hung, S.-C., Lee, J., Atanasova, K. R., Huang, P., Yilmaz, Ö., & Ojcius, D. M. (2015) · Cellular Microbiology · doi:10.1111/cmi.12560 · Cited by 122

Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

Li, J., & Burgess, D. J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.008 · Cited by 118

The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu

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Immune restoration following hematopoietic stem cell transplantation: an evolving target

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