Toll-like receptors in innate immunity

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 12×

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022

Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways

Fu, Y., Liu, B., Zhang, N., Liu, Z., Liang, D., Li, F., Cao, Y., Feng, X., Zhang, X., & Yang, Z. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.10.051 · Cited by 110

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production

Chen, C.-H., Floyd, H., Olson, N. E., Magaletti, D. M., Li, C., Draves, K. E., & Clark, E. A. (2005) · Blood · doi:10.1182/blood-2005-08-3264 · Cited by 111

Oligonucleotide Therapeutics: Chemistry, Delivery and Clinical Progress

Sharma, V. K., & Watts, J. K. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.144 · Cited by 112

Neurohormonal Modulation of the Innate Immune System Is Proinflammatory in the Prehypertensive Spontaneously Hypertensive Rat, a Genetic Model of Essential Hypertension

Harwani, S. C., Chapleau, M. W., Legge, K. L., Ballas, Z. K., & Abboud, F. M. (2012) · Circulation Research · doi:10.1161/circresaha.112.277475 · Cited by 110

What Can We Learn About Human Disease from the Nematode C. elegans?

Apfeld, J., & Alper, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7471-9_4 · Cited by 116

Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy

Zhang, L. L., Xie, X.-X., Liu, D., Xu, Z. P., & Liu, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.015 · Cited by 112

Pathogen specific cytokine release reveals an effect of TLR2 Arg753Gln during Candida sepsis in humans

Woehrle, T., Du, W., Goetz, A., Hsu, H., Joos, T. O., Weiss, M., Bauer, U. U. I., Brueckner, U. B., & Schneider, E. M. (2008) · Cytokine · doi:10.1016/j.cyto.2007.12.006 · Cited by 107

Toll-like receptors in skin infections and inflammatory diseases

Lai, Y., & Gallo, R. (2008) · Infectious Disorders - Drug Targets · doi:10.2174/1871526510808030144 · Cited by 119

Immunologic Characteristics of Preeclampsia, a Comprehensive Review

Ahn, H.-K., Park, J.-C., Gilman‐Sachs, A., & Kwak-Kim, J. Y.-H. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00913.x · Cited by 107

Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment

Thi, H. T. H., & Hong, S. (2017) · Journal of Cancer Prevention · doi:10.15430/jcp.2017.22.2.62 · Cited by 111

Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors

Pandey, G. N., Rizavi, H. S., Bhaumik, R., & Ren, X. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.024 · Cited by 110

Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis

Pabst, S., Baumgarten, G., Stremmel, A., Lennarz, M., Knüfermann, P., Gillissen, A., Vetter, H., & Grohé, C. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03008.x · Cited by 110

Presence of functional TLR2 and TLR4 on human adipocytes

Bès-Houtmann, S., Roche, R., Hoareau, L., Gonthier, M., Festy, F., Caillens, H., Gasque, P., d’Hellencourt, C. L., & Césari, M. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0230-1 · Cited by 114

Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4

Chang, E., Kim, H. J., Ha, J., Kim, H. J., Ryu, J., Park, K., Kim, H., Lee, Z. H., Kim, H., Fisher, D. E., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03310 · Cited by 108

Finding the needle in the haystack: systematic identification of psychobiotics

Bambury, A., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14127 · Cited by 108

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

Chan, M., Hayashi, T., Kuy, C. S., Gray, C. S., Wu, C. C. N., Corr, M., Wrasidlo, W., Cottam, H. B., & Carson, D. A. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900054q · Cited by 107

Regulatory effects of TLR2 on megakaryocytic cell function

Beaulieu, L. M., Lin, E., Morin, K. M., Tanrıverdi, K., & Freedman, J. E. (2011) · Blood · doi:10.1182/blood-2010-09-304949 · Cited by 107

Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages

Liang, X., Lin, T., Sun, G., Beasley-Topliffe, L., Cavaillon, J.-M., & Warren, H. S. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208742 · Cited by 106

Inflammasome Activation of IL‐1 Family Mediators in Response to Cutaneous Photodamage†

Nasti, T. H., & Timares, L. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01182.x · Cited by 107

The Role of TLR2 and 4-Mediated Inflammatory Pathways in Endothelial Cells Exposed to High Glucose

Mudaliar, H., Pollock, C. A., Ma, J., Wu, H., Chadban, S. J., & Panchapakesan, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108844 · Cited by 106

The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Lin, Q., Li, M., Fang, D., Fang, J., & Su, S. B. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.04.026 · Cited by 109

Identification of Francisella tularensis Lipoproteins That Stimulate the Toll-like Receptor (TLR) 2/TLR1 Heterodimer

Thakran, S., Li, H., Lavine, C. L., Miller, M. A., Bina, J. E., Bina, X. R., & Re, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706854200 · Cited by 106

Selenium inhibits Staphylococcus aureus-induced inflammation by suppressing the activation of the NF-κB and MAPK signalling pathways in RAW264.7 macrophages

Bi, C., Wang, H., Wang, Y., Sun, J., Dong, J., Meng, X., & Li, J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.044 · Cited by 108

Mechanism of macrophage activation by (1,4)-α-d-glucan isolated from Tinospora cordifolia

Nair, P., Melnick, S. J., Ramachandran, R., Escalon, E., & Ramachandran, C. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.07.028 · Cited by 105

New Players in TLR-Mediated Innate Immunity: PI3K and Small Rho GTPases

Ruse, M., & Knaus, U. G. (2006) · Immunologic Research · doi:10.1385/ir:34:1:33 · Cited by 105

Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing

Maerz, J. K., Steimle, A., Lange, A., Bender, A., Fehrenbacher, B., & Frick, J.-S. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1344810 · Cited by 105

Effect of dietary Bacillus coagulans supplementation on growth performance and immune responses of broiler chickens challenged by Salmonella enteritidis

Zhen, W., Shao, Y., Gong, X., Wu, Y., Geng, Y., Wang, Z., & Guo, Y. (2018) · Poultry Science · doi:10.3382/ps/pey119 · Cited by 104

Human Skin Endothelial Cells Can Express All 10TLRGenes and Respond to Respective Ligands

Fitzner, N., Clauberg, S., Eßmann, F., Liebmann, J., & Kolb-Bachofen, V. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00257-07 · Cited by 104

Sphingomyelin and Its Role in Cellular Signaling

Chakraborty, M., & Jiang, X. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-6331-9_1 · Cited by 108

Autophagy and senescence in fibrosing cholangiopathies

Nakanuma, Y., Sasaki, M., & Harada, K. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.027 · Cited by 105

Poly(ADP-ribosyl)ation in plants

Briggs, A. G., & Bent, A. F. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.03.008 · Cited by 105

TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

Wang, Z., Fayngerts, S., Wang, P., Sun, H., Johnson, D. S., Ruan, Q., Guo, W., & Chen, Y. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204525109 · Cited by 103

Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review

López‐Mejías, R., Castañeda, S., Genre, F., Remuzgo‐Martínez, S., Carmona, F. D., Llorca, J., Blanco, R., Martin, J. J., & González-Gay, M. Á. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.11.024 · Cited by 108

Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population

Cheng, P., Eng, H., Chou, M.-H., You, H., & Lin, T. (2007) · Translational research · doi:10.1016/j.trsl.2007.03.010 · Cited by 103

Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway

Balloy, V., Sallenave, J.-M., Wu, Y., Touqui, L., Latgé, J.-P., Si-Tahar, M., & Chignard, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803149200 · Cited by 102

The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors

Guo, L., & Schluesener, H. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6494-3 · Cited by 102

Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis

AbuMaziad, A. S., Schaa, K. L., Bell, E. F., Dagle, J. M., Cooper, M. E., Marazita, M. L., & Murray, J. C. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181e6a068 · Cited by 102

Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?

Moran, G. W., Leslie, F. C., Levison, S., & McLaughlin, J. T. (2008) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x08093943 · Cited by 112

The innate immune response to allotransplants: mechanisms and therapeutic potentials

Ochando, J., Ordikhani, F., Boros, P., & Jordan, S. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0216-2 · Cited by 108

The emerging role of exosomes in innate immunity, diagnosis and therapy

Gangadaran, P., Madhyastha, H., Madhyastha, R., Rajendran, R. L., Nakajima, Y., Watanabe, N., Velikkakath, A. K. G., Hong, C. M., Gopi, R. V., Muthukaliannan, G. K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1085057 · Cited by 105

Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts

Cho, M., Ju, J., Kim, H., Oh, H.-J., Kang, C., Jhun, J., Lee, S.-Y., Park, M., Min, J., Park, S., et al. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.11.005 · Cited by 105

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Tamrakar, A. K., Schertzer, J. D., Chiu, T. T., Foley, K. P., Bilan, P. J., Philpott, D. J., & Klip, A. (2010) · Endocrinology · doi:10.1210/en.2010-0437 · Cited by 107

Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

Sun, M., Deng, B., Zhao, X., Gao, C., Yang, L., Zhao, H., Yu, D., Zhang, F., Xu, L., Chen, L., et al. (2015) · Scientific Reports · doi:10.1038/srep11445 · Cited by 99

Evolution of Recognition of Ligands from Gram-Positive Bacteria: Similarities and Differences in the TLR2-Mediated Response between Mammalian Vertebrates and Teleost Fish

Ribeiro, C. M. S., Hermsen, T., Taverne-Thiele, A. J., Savelkoul, H. F. J., & Wiegertjes, G. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900990 · Cited by 103

CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help

Hernandez, M. G. H., Shen, L., & Rock, K. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2844 · Cited by 101

Toll-Like Receptor-Initiated Testicular Innate Immune Responses in Mouse Leydig Cells

Shang, T., Zhang, X., Wang, T., Sun, B., Deng, T., & Han, D. (2011) · Endocrinology · doi:10.1210/en.2011-0031 · Cited by 102

Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication

Broering, R., Wu, J., Meng, Z., Hilgard, P. A., Lu, M., Trippler, M., Szczeponek, A., Gerken, G., & Schlaak, J. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.028 · Cited by 101

Distinct Roles for MyD88 and Toll-Like Receptors 2, 5, and 9 in Phagocytosis ofBorrelia burgdorferiand Cytokine Induction

Shin, O. S., Isberg, R. R., Akira, S., Uematsu, S., Behera, A. K., & Hu, L. T. (2008) · Infection and Immunity · doi:10.1128/iai.01600-07 · Cited by 100

The role of TLRs in cervical cancer with HPV infection: a review

Yang, X. Y., Cheng, Y., & Li, C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.55 · Cited by 102

Toll‐Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Noh, J.-Y., Yoon, S. R., Kim, T., Choi, I., & Jung, H. (2020) · Journal of Immunology Research · doi:10.1155/2020/2045860 · Cited by 104

Innate Immune Receptors, Key Actors in Cardiovascular Diseases

Jaén, R. I., Val‐Blasco, A., Prieto, P., Fernández, M. G., Smani, T., Lopez-Sendon, J. L., Delgado, C., Boscá, L., & Fernández‐Velasco, M. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.03.015 · Cited by 101

Anti‐inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria‐derived factors

Nakanishi, T., Mukai, K., Yumoto, H., Hirao, K., Hosokawa, Y., & Matsuo, T. (2010) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2010.00714.x · Cited by 100

Untitled work

Streit (2005) · doi:10.1179/016164105x49463 · Cited by 100

ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes

Zhang, C., Bai, N., Chang, A., Zhang, Z.-H., Yin, J., Shen, W.-Z., Tian, Y., Xiang, R., & Liu, C.-H. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2012.57 · Cited by 103

The Contribution of the Maternal Immune System to the Establishment of Pregnancy in Cattle

Fair, T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00007 · Cited by 109

Contribution of Cytokines to Tissue Damage During Human Respiratory Syncytial Virus Infection

Böhmwald, K., Gálvez, N. M. S., Canedo-Marroquín, G., Pizarro-Ortega, M. S., Andrade, C. A., Gómez‐Santander, F., & Kalergis, A. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00452 · Cited by 99

Proinflammatory Cytokine Production in Liver Regeneration Is Myd88 -Dependent, but Independent of Cd14 , Tlr2 , and Tlr4

Campbell, J. S., Riehle, K. J., Brooling, J. T., Bauer, R. L., Mitchell, C., & Fausto, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2522 · Cited by 100

The Role of IFN-α and Nitric Oxide in the Release of HMGB1 by RAW 264.7 Cells Stimulated with Polyinosinic-Polycytidylic Acid or Lipopolysaccharide

Jiang, W., & Pisetsky, D. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3337 · Cited by 100

Mice Deficient in MyD88 Develop a Th2-Dominant Response and Severe Pathology in the Upper Genital Tract following Chlamydia muridarum Infection

Chen, L., Lei, L., Chang, X., Li, Z., Lu, C., Zhang, X., Wu, Y., Yeh, I., & Zhong, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901593 · Cited by 99

Expression and distribution of Toll-like receptors 11–13 in the brain during murine neurocysticercosis

Mishra, B. B., Gundra, U. M., & Teale, J. M. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-53 · Cited by 102

High-resolution microbiome profiling uncoversFusobacterium nucleatum,Lactobacillus gasseri/johnsonii, andLactobacillus vaginalisassociated to oral and oropharyngeal cancer in saliva from HPV positive and HPV negative patients treated with surgery and chemo-radiation

Guerrero-Preston, R. E., White, J. R., Godoy‐Vitorino, F., Rodríguez-Hilario, A., Navarro, K., González, H., Michailidi, C., Jedlicka, A., Canapp, S., Bondy, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20677 · Cited by 98

Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues

Bosch, P. S., Makhijani, K., Herboso, L., Gold, K. S., Baginsky, R., Woodcock, K. J., Alexander, B., Kukar, K., Corcoran, S., Jacobs, T., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.10.017 · Cited by 106

The role of macrophages in inflammatory bowel diseases

Heinsbroek, S. E. M., & Gordon, S. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001069 · Cited by 99

Lipotoxicity in NASH

Fuchs, M., & Sanyal, A. J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.019 · Cited by 97

Collaborative Action of Toll-Like and Nod-Like Receptors as Modulators of the Inflammatory Response to Pathogenic Bacteria

Oviedo-Boyso, J., Bravo-Patiño, A., & Baizabal-Aguirre, V. M. (2014) · Mediators of Inflammation · doi:10.1155/2014/432785 · Cited by 101

Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid–Induced cPLA2/COX-2–Dependent Airway Inflammatory Responses

Lee, I., Lee, C., Tung, W., Wang, S., Lin, C., Shu, J., & Yang, C. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090714 · Cited by 97

TAK1 Is a Central Mediator of NOD2 Signaling in Epidermal Cells

Kim, J., Omori, E., Matsumoto, K., Núñez, G., & Ninomiya‐Tsuji, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704746200 · Cited by 98

A universal epitope-based influenza vaccine and its efficacy against H5N1

Adar, Y., Singer, Y., Levi, R., Tzehoval, E., Perk, S., Banet-Noach, C., Nagar, S., Arnon, R., & Ben-Yedidia, T. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.02.011 · Cited by 97

Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK‐M

Harada, K., Isse, K., Sato, Y., Ozaki, S., & Nakanuma, Y. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01325.x · Cited by 97

Crosstalk between Complement and Toll-Like Receptors

Song, W. (2011) · Toxicologic Pathology · doi:10.1177/0192623311428478 · Cited by 99

Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization

Krüger, C. L., Zeuner, M.-T., Cottrell, G. S., Widera, D., & Heilemann, M. (2017) · Science Signaling · doi:10.1126/scisignal.aan1308 · Cited by 96

Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense

Wang, W., Song, X., Wang, L., & Song, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030721 · Cited by 96

TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

Fore, F., Indriputri, C., Mamutse, J., & Nugraha, J. (2020) · Immune Network · doi:10.4110/in.2020.20.e21 · Cited by 96

Porcine Toll-like receptors: The front line of pathogen monitoring and possible implications for disease resistance

Uenishi, H., & Shinkai, H. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.06.001 · Cited by 105

Tick-borne encephalitis virus and the immune response of the mammalian host

Dörrbecker, B., Dobler, G., Spiegel, M., & Hufert, F. T. (2010) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2010.05.010 · Cited by 96

Neuroprotective Effects of Endurance Exercise Against High‐Fat Diet‐Induced Hippocampal Neuroinflammation

Kang, E., Koo, J., Jang, Y. C., Yang, C. ‐., Lee, Y., Cosío-Lima, L., & Cho, J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12385 · Cited by 96

Obesity and NAFLD

Duseja, A. K., & Chawla, Y. K. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.002 · Cited by 97

Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG

Yan, S., Rolfe, B. E., Zhang, B., Mohammed, Y., Gu, W., & Xu, Z. P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.055 · Cited by 95

Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism

Cain, D. W., Snowden, P. B., Sempowski, G. D., & Kelsoe, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019957 · Cited by 95

Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs

Lyn‐Cook, B. D., Xie, C., Oates, J. R., Treadwell, E. L., Word, B. R., Hammons, G., & Wiley, K. L. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.05.001 · Cited by 93

Toll-Like Receptors Differentially Regulate CC and CXC Chemokines in Skeletal Muscle via NF-κB and Calcineurin

Boyd, J. H., Divangahi, M., Yahiaoui, L., Gvozdic, D., Qureshi, S. T., & Petrof, B. J. (2006) · Infection and Immunity · doi:10.1128/iai.00286-06 · Cited by 95

Transcriptional response of BmToll9-1 and RNAi machinery genes to exogenous dsRNA in the midgut of Bombyx mori

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Pattern Recognition Receptors in Cancer Progression and Metastasis

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Toll-Like Receptors in Innate Immunity: Role of Bacterial Endotoxin and Toll-Like Receptor 4 in Endometrium and Endometriosis

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Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes

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Prospects for recombinant vaccines against Babesia bovis and related parasites

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TLR ligands differentially affect uptake and presentation of cellular antigens

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Asthma and Allergies in Rural Areas of Europe

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Animal models: an important tool in mycology

Capilla, J., Clemons, K. V., & Stevens, D. A. (2007) · Medical Mycology · doi:10.1080/13693780701644140 · Cited by 94

Pathogenesis of ANCA-associated vasculitis: An update

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Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10

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The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections

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TLR-Induced Local Metabolism of Vitamin D3 Plays an Important Role in the Diversification of Adaptive Immune Responses

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Toll-like receptor recognition of Toxoplasma gondii

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NOX enzymes and Toll-like receptor signaling

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Identification and analysis of Toll-related genes in the domesticated silkworm, Bombyx mori

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Passive and active components of neonatal innate immune defenses

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The T Antigen Locus of Merkel Cell Polyomavirus Downregulates Human Toll-Like Receptor 9 Expression

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Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

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Mitogen-activated Protein Kinases in Inflammation

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Review Article Toll-like receptors in innate immunity

Takeda, K., & Akira, S. (2013)

Toll-like receptor

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Toll-like Receptors are Key Participants in Innate Immune Responses

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Toll-like Receptors and their Adaptors in Innate Immunity

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Regulation of Toll-like receptor signaling in the innate immunity

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