Quinides of roasted coffee enhance insulin action in conscious rats
Open accessAbstract
Consumption of large amounts of coffee has been shown to decrease the incidence of type 2 diabetes. However, the specific compounds and mechanisms responsible for this effect are not known. The aim of this study was to determine the effects of a decaffeinated coffee extract and a synthetic quinide, representative of those found in roasted coffee, 3,4-diferuloyl-1,5-quinolactone, on insulin-stimulated glucose disposal and muscle glucose uptake. Experiments were performed on conscious rats during hyperinsulinemic, euglycemic clamps receiving gastric infusions of saline, a decaffeinated coffee extract (DECAF) (220 mg/kg), or 3,4-diferuloyl-1,5-quinide (DIFEQ) (110 mg/kg). Following treatment, rats received an intravenous bolus of deoxy-[2-3H] glucose to assess muscle glucose uptake (Rg, micromol x 100 g(-1) x min(-1)). Glucose infusions [mg/(kg x min)] required to maintain euglycemia during the tracer period were higher with DIFEQ (14.6 +/- 0.7) than with saline (10.8 +/- 0.7) and DECAF (11.5 +/- 1.1). Despite increased glucose requirements, Rg in skeletal (soleus, gastrocnemius, superficial vastus lateralis) and cardiac muscle were unchanged. DECAF or DIFEQ did not affect heart rate, blood pressure, plasma nonesterified fatty acids or liver aminotransferase activity. These results demonstrate that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg.
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Chlorogenic and quinide compounds found in coffee are suggested to decrease glucose absorption and enhance nonskeletal muscle glucose disposal, respectively.
“In terms of glucose metabolism, both the chlorogenic and quinide compounds found in coffee are suggested to decrease glucose absorption (16) and enhance nonskeletal muscle glucose disposal (17), respectively.”
From The Glucose Intolerance Induced by Caffeinated Coffee Ingestion Is Less Pronounced than That Due to Alkaloid Caffeine in Men (2006) · cites this paper as [17]
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- Authors
- Shearer, J., Farah, A., de Paulis, T., Bracy, D. P., Pencek, R. R., Graham, T. E., & Wasserman, D. H.
- Affiliations
- Vanderbilt University (US)
- University of Guelph (CA)
- Corresponding author
- Shearer, Jane
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 133
- Issue
- 11
- Pages
- 3529-3532
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2112217857
- Cited by
- 154
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 10
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA54902)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- roasted coffee, insulin action, insulin-stimulated glucose disposal, muscle glucose uptake, type 2 diabetes prevention, hyperinsulinemic-euglycemic clamp, skeletal muscle glucose uptake
- MeSH terms
- Insulin Secretion, Animals, Blood Glucose, Blood Pressure, Coffee, Coumaric Acids, Deoxyglucose, Fatty Acids, Nonesterified, Heart Rate, Insulin, Lactones, Male, Radioisotope Dilution Technique, Tritium, Glucose Clamp Technique, Rats, Sprague-Dawley, Muscle, Skeletal, Rats
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