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Cited by 122Coffee research and impactsNutritional Studies and DietAcute Ischemic Stroke Management

Coffee and tea consumption and risk of stroke subtypes in male smokers

Larsson, Susanna C., Männistö, Satu, Virtanen, Mikko J., Kontto, Jukka, Albanes, Demetrius, Virtamo, Jarmo·2008·Stroke
DOI 10.1161/strokeaha.107.504183
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Abstract

BACKGROUND AND PURPOSE: Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS: We used prospective data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a cohort study of 26 556 male Finnish smokers aged 50 to 69 years without a history of stroke at baseline. Coffee and tea consumption was assessed at baseline using a validated food-frequency questionnaire. During a mean follow-up of 13.6 years, from 1985 through December 2004, 2702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were ascertained from national registries. RESULTS: After adjustment for age and cardiovascular risk factors, both consumption of coffee and tea was statistically significantly inversely associated with the risk of cerebral infarction but not intracerebral or subarachnoid hemorrhage. The multivariate relative risk of cerebral infarction for men in the highest category of coffee consumption (>/=8 cups/d) was 0.77 (95% CI, 0.66 to 0.90; P for trend <0.001) compared with those in the lowest category (<2 cups/d). The corresponding relative risk comparing men in the highest category of tea consumption (>/=2 cups/d) with those in the lowest category (nondrinkers) was 0.79 (95% CI, 0.68 to 0.92; P for trend=0.002). CONCLUSIONS: These results suggest that high consumption of coffee and tea may reduce the risk of cerebral infarction among men, independent of known cardiovascular risk factors.

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  • In the study by Larsson et al. (2008), consumption of caffeinated coffee, caffeinated tea or total caffeine was not associated with an increased risk of ischaemic or haemorrhagic stroke.

    “Consumption of caffeinated coffee, caffeinated tea or total caffeine (from coffee and tea) was not associated with an increased risk of ischaemic or haemorrhagic stroke.”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Larsson et al. (2008)

  • In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of men, smokers who drank 8 or more cups of coffee per day had a 23% lower risk of stroke than those who drank fewer than 2 cups per day.

    “In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of men, smokers who drank 8 or more cups of coffee per day had a 23% lower risk of stroke than those who drank fewer than 2 cups per day.25”

    From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [25]

  • There have been discrepant findings on the association between habitual coffee intake and ischemic stroke.

    “There have been discrepant findings on the association between habitual coffee intake and ischemic stroke.”

    From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [25]

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  1. Mishkinsky J, Joseph B, Sulman FG. Hypoglycaemic effect of trigo- nelline. Lancet. 1967;2:1311-1312.

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Authors
Larsson, S. C., Männistö, S., Virtanen, M. J., Kontto, J., Albanes, D., & Virtamo, J.
Affiliations
  • National Institutes of Health (US)
  • From National Institute of Environmental Medicine (S.C.L), Karolinska Institutet, Stockholm, Sweden; the Department of Health Promotion and Chronic Disease Prevention (S.M., M.J.V., J.K., J.V.), National Public Health Institute, Helsinki, Finland; and National Cancer Institute (D.A.), National Institute of Health, Bethesda, Md.
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-06
Volume
39
Issue
6
Pages
1681-1687
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/strokeaha.107.504183
OpenAlex
W2125894220
Cited by
122
References
45
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 18
FWCI
7.89
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (N01-RC- 45035, N01RC37004, n01rc37004-9-0-0, n01cn045165-030)
  • National Cancer Institute (N01 CN 45165)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
coffee consumption, tea consumption, stroke subtypes, cerebral infarction, intracerebral hemorrhage, subarachnoid hemorrhage, male smokers, antioxidant beverages, cardiovascular risk factors, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
MeSH terms
Age Factors, Aged, Antioxidants, Cerebral Hemorrhage, Coffee, Finland, Humans, Insulin Resistance, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, Sex Factors, Smoking, Tea, Cohort Studies, Stroke, Hypoxia-Ischemia, Brain

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