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Cited by 358Coffee research and impactsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Caffeine Can Decrease Insulin Sensitivity in Humans

Keijzers, Gerben B., De Galan, Bastiaan E., Tack, Cees J., Smits, Paul·2002·Diabetes Care
DOI 10.2337/diacare.25.2.364
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Abstract

Objective Caffeine is a central stimulant that increases the release of catecholamines. As a component of popular beverages, caffeine is widely used around the world. Its pharmacological effects are predominantly due to adenosine receptor antagonism and include release of catecholamines. We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. Research design and methods Hyperinsulinemic-euglycemic glucose clamps were used to assess insulin sensitivity. Caffeine or placebo was administered intravenously to 12 healthy volunteers in a randomized, double-blind, crossover design. Measurements included plasma levels of insulin, catecholamines, free fatty acids (FFAs), and hemodynamic parameters. Insulin sensitivity was calculated as whole-body glucose uptake corrected for the insulin concentration. In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. Results Caffeine decreased insulin sensitivity by 15% (P Conclusions Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels. Because dipyridamole did not affect glucose uptake, peripheral adenosine receptor antagonism does not appear to contribute to this effect.

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  • Caffeine is known to acutely decrease insulin sensitivity in human subjects.

    “Moreover, caffeine is known to acutely decrease insulin sensitivity in human subjects (Graham et al. 2000;Keijzers et al. 2002).”

    From Glycaemic index methodology (2005) · cites this paper as Keijzers et al. 2002

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Authors
Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P.
Affiliations
Department of Internal Medicine, University Medical Center, Nijmegen, the Netherlands
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2002-02-01
Volume
25
Issue
2
Pages
364-369
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.25.2.364
OpenAlex
W2112839007
Cited by
358
References
42
Citations by year
2026: 8 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 20
FWCI
10.64
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
caffeine, insulin sensitivity, insulin resistance, catecholamines, epinephrine, norepinephrine, adenosine receptor antagonism, dipyridamole, free fatty acids, glucose uptake, hyperinsulinemic-euglycemic clamp, blood pressure
MeSH terms
Adult, Central Nervous System Stimulants, Caffeine, Dipyridamole, Double-Blind Method, Epinephrine, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Male, Norepinephrine, Phosphodiesterase Inhibitors, Glucose Clamp Technique

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