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Cited by 154Coffee research and impactsNatural Antidiabetic Agents StudiesMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 22 of the 23 references it cites were found in a registry or an index.

Quinides of Roasted Coffee Enhance Insulin Action in Conscious Rats

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Shearer, Jane, Farah, Adriana, de Paulis, Tomas, Bracy, Deanna P., Pencek, R. Richard, Graham, Terry E., Wasserman, David H.·2003·The Journal of Nutrition
DOI 10.1093/jn/133.11.3529
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Abstract

Consumption of large amounts of coffee has been shown to decrease the incidence of type 2 diabetes. However, the specific compounds and mechanisms responsible for this effect are not known. The aim of this study was to determine the effects of a decaffeinated coffee extract and a synthetic quinide, representative of those found in roasted coffee, 3,4-diferuloyl-1,5-quinolactone, on insulin-stimulated glucose disposal and muscle glucose uptake. Experiments were performed on conscious rats during hyperinsulinemic, euglycemic clamps receiving gastric infusions of saline, a decaffeinated coffee extract (DECAF) (220 mg/kg), or 3,4-diferuloyl-1,5-quinide (DIFEQ) (110 mg/kg). Following treatment, rats received an intravenous bolus of deoxy-[2-3H] glucose to assess muscle glucose uptake (Rg, micromol x 100 g(-1) x min(-1)). Glucose infusions [mg/(kg x min)] required to maintain euglycemia during the tracer period were higher with DIFEQ (14.6 +/- 0.7) than with saline (10.8 +/- 0.7) and DECAF (11.5 +/- 1.1). Despite increased glucose requirements, Rg in skeletal (soleus, gastrocnemius, superficial vastus lateralis) and cardiac muscle were unchanged. DECAF or DIFEQ did not affect heart rate, blood pressure, plasma nonesterified fatty acids or liver aminotransferase activity. These results demonstrate that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg.

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Crossref · 10.1093/jn/133.11.3529

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Research works printed but not linked: 3

  1. Salazar-Martinez, 2003, Coffee consumption and risk of type 2 diabetes in men and women, Diabetes, 52, A72
  2. Chown, 2001, Caffeine increases the insulin/glucose response to an OGTT in obese, resting males, Can. J. Appl. Physiol, 26, S249
  3. Farah, A., de Paulis, T., Trugo, L. C. & Martin, P. R. (2003) Effect of roasting on the formation of chlorogenic acid lactones in coffee. In: Proceedings of the 20th ASIC International Scientific Colloquium on Coffee. Koloa, HI.

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Metadata

Authors
Shearer, J., Farah, A., de Paulis, T., Bracy, D. P., Pencek, R. R., Graham, T. E., & Wasserman, D. H.
Affiliations
  • Vanderbilt University (US)
  • University of Guelph (CA)
Corresponding author
Shearer, Jane
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2003-11
Volume
133
Issue
11
Pages
3529-3532
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/133.11.3529
OpenAlex
W2112217857
Cited by
154
References
23
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 10
FWCI
4.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA54902)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
roasted coffee, insulin action, insulin-stimulated glucose disposal, muscle glucose uptake, type 2 diabetes prevention, hyperinsulinemic-euglycemic clamp, skeletal muscle glucose uptake
MeSH terms
Insulin Secretion, Animals, Blood Glucose, Blood Pressure, Coffee, Coumaric Acids, Deoxyglucose, Fatty Acids, Nonesterified, Heart Rate, Insulin, Lactones, Male, Radioisotope Dilution Technique, Tritium, Glucose Clamp Technique, Rats, Sprague-Dawley, Muscle, Skeletal, Rats

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