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Cinnamon Supplementation Does Not Improve Glycemic Control in Postmenopausal Type 2 Diabetes Patients
Open accessAbstract
In vitro and in vivo animal studies have reported strong insulin-like or insulin-potentiating effects after cinnamon administration. Recently, a human intervention study showed that cinnamon supplementation (1 g/d) strongly reduced fasting blood glucose concentration (30%) and improved the blood lipid profile in patients with type 2 diabetes. The objective of this study was to investigate the effects of cinnamon supplementation on insulin sensitivity and/or glucose tolerance and blood lipid profile in patients with type 2 diabetes. Therefore, a total of 25 postmenopausal patients with type 2 diabetes (aged 62.9 +/- 1.5 y, BMI 30.4 +/- 0.9 kg/m2) participated in a 6-wk intervention during which they were supplemented with either cinnamon (Cinnamomum cassia, 1.5 g/d) or a placebo. Before and after 2 and 6 wk of supplementation, arterialized blood samples were obtained and oral glucose tolerance tests were performed. Blood lipid profiles and multiple indices of whole-body insulin sensitivity were determined. There were no time x treatment interactions for whole-body insulin sensitivity or oral glucose tolerance. The blood lipid profile of fasting subjects did not change after cinnamon supplementation. We conclude that cinnamon supplementation (1.5 g/d) does not improve whole-body insulin sensitivity or oral glucose tolerance and does not modulate blood lipid profile in postmenopausal patients with type 2 diabetes. More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made.
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“Cinnamon extracts have been known for managing blood glucose.”
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“Results from 6 RCTs did not find a difference in blood glucose or insulin levels after cinnamon consumption [368,377,378,379,380,381,382].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [382]
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Metadata
- Authors
- Vanschoonbeek, K., Thomassen, B. J., Senden, J. M., Wodzig, W. K., & van Loon, L. J.
- Affiliations
- Maastricht University (NL)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Vanschoonbeek, Kristof
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 136
- Issue
- 4
- Pages
- 977-980
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2095773990
- Cited by
- 241
- References
- 21
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 14 · 2023: 9 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 7 · 2017: 9 · 2016: 16 · 2015: 11 · 2014: 14 · 2013: 11 · 2012: 14
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
- Keywords
- cinnamon supplementation, Cinnamomum cassia, type 2 diabetes, postmenopausal women, glycemic control, insulin sensitivity, oral glucose tolerance, lipid profile, fasting blood glucose
- MeSH terms
- Blood Glucose, Energy Intake, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Fasting, Female, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Lipids, Middle Aged, Placebos, Body Mass Index, Postmenopause, Dietary Supplements
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