Clinicopathological and genetic characteristics in Chinese patients with lipoprotein glomerulopathy
Abstract
Objective: In this study, we report on 16 Chinese patients with biopsy-proven lipoprotein glomerulopathy (LPG) investigated for clinical manifestations, pathological characteristics and apolipoprotein E (apoE) genetic analysis. Methods: A retrospective analysis of the clinical and pathological features was made in 16 patients with LPG. Plasma concentrations and genetic analysis of apoE were completed. Glomerular depositions of apoA, apoB and apoE were detected using monoclonal antibodies on cryostatic sections in all patients. Results: All 16 patients presented with edema; 14 presented with nephrotic syndrome. Anemia, microhematuria, hypertension and abnormal levels of serum creatinine were detected in 12 patients (75%), 11 patients (69%), 8 patients (50%) and 6 patients (37.5%), respectively. All the patients showed hypertriglyceridemia, while only 7 showed slight hypercholesterolemia. The characteristic features of hyperlipidemia in these patients were approximately in accord with those of type IV hyperlipoproteinemia. Concentrations of apoB correlated with urine protein, triglycerides and cholesterol (r=0.558, p=0.038; r=0.6, p=0.023; r=0.65, p=0.012; respectively). No correlation was found between serum level of apoE and clinicopathological features in patients with LPG. The genotype of apoE-ε3/ε4 is the predominant one in Chinese patients with LPG. No mutated forms of apoE were found, compared with previous reports. Conclusion: Unique clinicopathological and genetic features were found in this group of Chinese patients with LPG compared with the general population, including lower serum levels of apoE and cholesterol, as well as anemia and microhematuria. Multiple factors other than apoE were involved in the pathogenesis of LPG.
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DNA from 17 patients with LPG were reported to have no apoE variants.
“However, DNA from 17 patients with LPG were reported to have no apoE variants6).”
From The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T＞C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy (2018) · cites this paper as [6]
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- Authors
- Zhang, B., Liu, Z.-H., Zeng, C.-H., Zheng, J.-M., Chen, H.-P., & Li, L.-S.
- Affiliations
- Nanjing General Hospital of Nanjing Military Command (CN)
- Research Institute of Nephrology, Jinling Hospital, Nanjing - China 1
- Corresponding author
- Zhang, Bo
- Venue
- Journal of Nephrology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-01
- Volume
- 21
- Issue
- 1
- Pages
- 110-117
- ISSN
- 1121-8428 (ISSN-L)
- 1724-6059
- OpenAlex
- W2407528964
- Cited by
- 12
- References
- 26
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein glomerulopathy, apolipoprotein E, apolipoprotein B, apolipoprotein(a), type IV hyperlipoproteinemia, hypertriglyceridemia, nephrotic syndrome, APOE genotype, Chinese patients, clinicopathological features, pathogenesis
- MeSH terms
- Adolescent, Adult, Apolipoproteins E, Child, Female, Genotype, Humans, Kidney Diseases, Kidney Glomerulus, Lipoproteins, Male, Middle Aged, Receptors, LDL
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