The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Treatment Adherence in Adolescents With Inflammatory Bowel Disease: The Collective Impact of Barriers to Adherence and Anxiety/Depressive Symptoms
Open accessAbstract
OBJECTIVE: Knowledge of factors impacting adolescents' ability to adhere to their inflammatory bowel disease (IBD) regimen is limited. The current study examines the collective impact of barriers to adherence and anxiety/depressive symptoms on adolescent adherence to the IBD regimen. METHODS: Adolescents (n = 79) completed measures of barriers to adherence, adherence, and anxiety/depressive symptoms at one of two specialty pediatric IBD clinics. RESULTS: Most adolescents reported barriers to adherence and 1 in 8 reported borderline or clinically elevated levels of anxiety/depressive symptoms. Anxiety/depressive symptoms moderated the relationship between barriers to adherence and adherence. Post hoc probing revealed a significant, additive effect of higher anxiety/depressive symptoms in the barriers-adherence relationship, with adherence significantly lower among adolescents with higher barriers and higher anxiety/depressive symptoms. CONCLUSIONS: In order to optimize adherence in adolescents, interventions should target not only barriers to adherence but also any anxiety/depressive symptoms that may negatively impact efforts to adhere to recommended treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Indeed, comorbid psychological difficulties are associated with disease activity, flares, treatment response, and the necessity of surgical intervention [2,6,8,9,10,11,12,13,14,15].”
From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [11]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Health Belief Model: a decade later.
Janz, N. K., & Becker, M. H. (1984) · Health Education Quarterly · doi:10.1177/109019818401100101 · Cited by 8,437
Holmbeck, G. N. (1997) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.65.4.599 · Cited by 3,036
Holmbeck, G. N. (2002) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/27.1.87 · Cited by 1,866
Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy
Lichtiger, S., Present, D. H., Kornbluth, A. A., Gelernt, I. M., Bauer, J. J., Galler, G. W., Michelassi, F., & Hanauer, S. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406303302601 · Cited by 1,715
Depression and Diabetes Treatment Nonadherence: A Meta-Analysis
Gonzalez, J. S., Peyrot, M., McCarl, L. A., Collins, E. M., Serpa, L., Mimiaga, M. J., & Safren, S. A. (2008) · Diabetes Care · doi:10.2337/dc08-1341 · Cited by 1,060
Development and Validation of a Pediatric Crohn's Disease Activity Index
Hyams, J. S., Ferry, G. D., Mandel, F. S., Gryboski, J. D., Kibort, P. M., Kirschner, B. S., Griffiths, A. M., Katz, A. J., Grand, R. J., Boyle, J. T., et al. (1991) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1991.tb10268.x · Cited by 1,054
Development and Validation of a Pediatric Crohnʼs Disease Activity Index
Hyams, J. S., Ferry, G. D., Mandel, F. S., Gryboski, J. D., Kibort, P. M., Kirschner, B. S., Griffiths, A. M., Katz, A. J., Grand, R. J., Boyle, J. T., et al. (1991) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199105000-00005 · Cited by 949
Kappelman, M. D., Rifas‐Shiman, S. L., KLEINMAN, K. P., Ollendorf, D., Bousvaros, A., Grand, R. J., & Finkelstein, J. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.012 · Cited by 931
Weissman, M. M., Orvaschel, H., & PADIAN, N. S. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198012000-00005 · Cited by 909
Handbook of pediatric psychology
(1988) · Choice Reviews Online · doi:10.5860/choice.26-2400 · Cited by 799
Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis
Kane, S. V., Huo, D., Aikens, J. E., & Hanauer, S. B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01383-9 · Cited by 568
Adherence to Pediatric Medical Regimens
Rapoff, M. A. (1999) · Springer eBooks · doi:10.1007/b102349 · Cited by 357
Evaluation of the Pediatric Crohn Disease Activity Index: A Prospective Multicenter Experience
Hyams, J. S., Markowitz, J. F., Otley, A. R., Rosh, J. R., Mack, D. R., Bousvaros, A., Kugathasan, S., Pfefferkorn, M. D., Tolia, V. K., Evans, J., et al. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000183350.46795.42 · Cited by 328
Depression among children with chronic medical problems: A meta-analysis
Bennett, D. S. (1994) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/19.2.149 · Cited by 322
Barriers to Treatment Adherence for Children with Cystic Fibrosis and Asthma: What Gets in the Way?
Modi, A. C., & Quittner, A. L. (2006) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsj096 · Cited by 301
Predictors of Adherence to Antiretroviral Medications in Children and Adolescents With HIV Infection
Williams, P. L., Storm, D. S., Montepiedra, G., Nichols, S., Kammerer, B. L., Sirois, P. A., Farley, J. J., Malee, K., & for the PACTG 219C Team (2006) · PEDIATRICS · doi:10.1542/peds.2006-0493 · Cited by 283
Perrin, E. C., Stein, R. E. K., & Drotar, D. (1991) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/16.4.411 · Cited by 247
Auvin, S., Molinié, F., Gower‐Rousseau, C., Brazier, F., Merle, V., Grandbastien, B., Marti, R., Lerebours, É., Dupas, J., Colombel, J., et al. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000162479.74277.86 · Cited by 222
Hauser, S. T., Jacobson, A. M., Lavori, P. W., Wolfsdorf, J. I., Herskowitz, R. D., Milley, J. E., Bliss, R., Wertlieb, D. L., & Stein, J. (1990) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/15.4.527 · Cited by 222
Longitudinal Antiretroviral Adherence Among Adolescents Infected With Human Immunodeficiency Virus
Murphy, D. A., Belzer, M. E., Durako, S. J., Sarr, M., Wilson, C. M., & Muenz, L. R. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.8.764 · Cited by 191
Brownlee-Duffeck, M., Peterson, L., Simonds, J. F., Goldstein, D., Kilo, C., & Hoette, S. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.55.2.139 · Cited by 190
Risk Taking, Depression, Adherence, and Symptom Control in Adolescents and Young Adults with Asthma
Bender, B. G. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200511-1706pp · Cited by 189
Higgins, P. D. R., Rubin, D. T., KAULBACK, K., SCHOENFIELD, P. S., & Kane, S. V. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03865.x · Cited by 180
Mikocka-Walus, A. A., Turnbull, D. A., Moulding, N. T., Wilson, I. G., Andrews, J. M., & Holtmann, G. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20062 · Cited by 178
A Developmental Perspective on Adolescent Health and Illness: An Introduction to the Special Issues
Holmbeck, G. N. (2002) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/27.5.409 · Cited by 174
Szigethy, E., Levy‐Warren, A., Whitton, S. W., Bousvaros, A., Gauvreau, K., Leichtner, A. M., & Beardslee, W. R. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200410000-00017 · Cited by 166
Bucks, R. S., Hawkins, K., Skinner, T. C., Horn, S., Seddon, P., & Horne, R. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn135 · Cited by 151
Medication Adherence and Quality of Life in Pediatric Inflammatory Bowel Disease
Hommel, K. A., Davis, C. M., & Baldassano, R. N. (2008) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn022 · Cited by 142
Perceived barriers to adherence among adolescent renal transplant candidates
Zelikovsky, N., Schast, A. P., Palmer, J., & Meyers, K. E. C. (2008) · Pediatric Transplantation · doi:10.1111/j.1399-3046.2007.00886.x · Cited by 132
The Illness Management Survey: Identifying Adolescents' Perceptions of Barriers to Adherence
Logan, D. E. (2003) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsg028 · Cited by 132
Brownlee-Duffeck, M., Peterson, L., Simonds, J. F., et al. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.2.139 · Cited by 130
Hommel, K. A., Davis, C. M., & Baldassano, R. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20798 · Cited by 127
Self-citationPsychosocial functioning in pediatric inflammatory bowel disease
MacKner, L. M., Crandall, W. V., & Szigethy, E. M. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000217769.83142.c6 · Cited by 122
Oral Medication Adherence in Pediatric Inflammatory Bowel Disease
Mackner, L. M., & Crandall, W. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000186409.15392.54 · Cited by 121
Long-Term Psychosocial Outcomes Reported by Children and Adolescents with Inflammatory Bowel Disease
Mackner, L. M., & Crandall, W. V. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41428.x · Cited by 116
Zelikovsky, N., & Schast, A. P. (2008) · PubMed · Cited by 111
Adverse Behavioral Effects of Treatment for Acute Exacerbation of Asthma in Children
Kayani, S., & Shannon, D. C. (2002) · CHEST Journal · doi:10.1378/chest.122.2.624 · Cited by 108
Brief Report: Psychosocial Adjustment in Adolescents with Inflammatory Bowel Disease
Mackner, L. M., & Crandall, W. (2005) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsj023 · Cited by 100
Special issues in pediatric inflammatory bowel disease
Dubinsky, M. C. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.14.413 · Cited by 99
Review: Psychosocial Issues in Pediatric Inflammatory Bowel Disease
Mackner, L. M. (2004) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsh027 · Cited by 98
Simons, L. E., McCormick, M. L., Devine, K. A., & Blount, R. L. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq025 · Cited by 97
Barriers to Oral Medication Adherence for Adolescents with Inflammatory Bowel Disease
Ingerski, L. M., Baldassano, R. N., Denson, L. A., & Hommel, K. A. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp085 · Cited by 97
Barriers to adherence among adolescents with inflammatory bowel disease
Greenley, R. N., Stephens, M., Doughty, A., Raboin, T., & Kugathasan, S. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20988 · Cited by 79
Behavioral Effects of Corticosteroids in Steroid-sensitive Nephrotic Syndrome
Soliday, E., Grey, S., & Lande, M. B. (1999) · PEDIATRICS · doi:10.1542/peds.104.4.e51 · Cited by 72
Treatment Adherence in Adolescents: Development and Psychopathology
Shaw, R. J. (2001) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104501006001011 · Cited by 67
Psychological factors affecting pediatric inflammatory bowel disease
Mackner, L. M., & Crandall, W. (2007) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3282ef4426 · Cited by 61
Oliva‐Hemker, M. M., Abadom, V., Cuffari, C., & Thompson, R. E. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31802b320e · Cited by 59
Short‐ and Long‐term Response to and Weaning from Infliximab Therapy in Pediatric Ulcerative Colitis
Fanjiang, G., Russell, G. H., & Katz, A. J. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31802e98d4 · Cited by 58
Special issues in pediatric inflammatory bowel disease
Fragaki, M., & Dubinsky (2008) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 50
Treatment Regimen Adherence in Pediatric Gastroenterology
Hommel, K. A., Mackner, L. M., Denson, L. A., & Crandall, W. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318175dda1 · Cited by 48
Greenley, R. N., Kunz, J. H., Biank, V., Martínez, A., Miranda, A., Noe, J. D., Telega, G. W., Tipnis, N. A., Werlin, S. L., & Stephens, M. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21859 · Cited by 42
New Drugs: Prescribing for infants and children
Rylance, G. (1988) · BMJ · doi:10.1136/bmj.296.6627.984 · Cited by 10
Research works printed but not linked: 2
- Holmbeck, 1997, Journal of consulting and clinical psychology, 65, 599, 10.1037/0022-006X.65.4.599 · DOI
- Zelikovsky, 2008, Pediatric nursing, 34, 141
Cited by
Sorted by citations
Lamb, C. A., Kennedy, N. A., Raine, T., Hendy, P. A., Smith, P. J., Limdi, J. K., Hayee, B., Lomer, M. C. E., Parkes, G. C., Selinger, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318484 · Cited by 2,346
Increased burden of psychiatric disorders in inflammatory bowel disease
Bernstein, C. N., Hitchon, C. A., Walld, R., Bolton, J. M., Sareen, J., Walker, J. R., Graff, L. A., Patten, S. B., Singer, A., Lix, L. M., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy235 · Cited by 274
Chen, L.-M., Bao, C., Wu, Y. H., Liang, S.-H., Wang, D., Wu, L.-Y., Huang, Y., Liu, H.-R., & Wu, H.-G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02175-2 · Cited by 243
Hanghøj, S., & Boisen, K. A. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.08.009 · Cited by 211
Etiology and Treatment of Pain and Psychosocial Issues in Patients With Inflammatory Bowel Diseases
Regueiro, M., Greer, J. B., & Szigethy, E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.036 · Cited by 142
Metadata
- Authors
- Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Journal of Pediatric Psychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-10
- Volume
- 37
- Issue
- 3
- Pages
- 282-291
- ISSN
- 0146-8693 (ISSN-L)
- 1465-735X
- PMC
- PMC3306169
- OpenAlex
- W2142245641
- Cited by
- 143
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 16 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 3
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pediatric Psychology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Procter and Gamble
- National Institutes of Health (5ul1rr026314-03, UL1TR000077, 1UL1RR026314)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK079037)
- National Center for Research Resources (1UL1RR026314, UL1-RR026314)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Adolescent and Pediatric Healthcare
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- inflammatory bowel disease, adolescents, medication adherence, barriers to adherence, anxiety symptoms, depressive symptoms, psychosocial factors, pediatric inflammatory bowel disease
- MeSH terms
- Adolescent, Adolescent Behavior, Anxiety, Colitis, Ulcerative, Crohn Disease, Depression, Female, Humans, Male, Severity of Illness Index, Inflammatory Bowel Diseases, Medication Adherence, Checklist
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
