Cited by 143Medication Adherence and ComplianceAdolescent and Pediatric HealthcareInflammatory Bowel Disease

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Treatment Adherence in Adolescents With Inflammatory Bowel Disease: The Collective Impact of Barriers to Adherence and Anxiety/Depressive Symptoms

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Gray, W. N., Denson, L. A., Baldassano, R. N., Hommel, K. A.·2012·Journal of Pediatric Psychology

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Abstract

OBJECTIVE: Knowledge of factors impacting adolescents' ability to adhere to their inflammatory bowel disease (IBD) regimen is limited. The current study examines the collective impact of barriers to adherence and anxiety/depressive symptoms on adolescent adherence to the IBD regimen. METHODS: Adolescents (n = 79) completed measures of barriers to adherence, adherence, and anxiety/depressive symptoms at one of two specialty pediatric IBD clinics. RESULTS: Most adolescents reported barriers to adherence and 1 in 8 reported borderline or clinically elevated levels of anxiety/depressive symptoms. Anxiety/depressive symptoms moderated the relationship between barriers to adherence and adherence. Post hoc probing revealed a significant, additive effect of higher anxiety/depressive symptoms in the barriers-adherence relationship, with adherence significantly lower among adolescents with higher barriers and higher anxiety/depressive symptoms. CONCLUSIONS: In order to optimize adherence in adolescents, interventions should target not only barriers to adherence but also any anxiety/depressive symptoms that may negatively impact efforts to adhere to recommended treatment.

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Authors: Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
ORCID: Denson, L. A.
Baldassano, R. N.
Hommel, K. A.
Venue: Journal of Pediatric Psychology
Publisher: Oxford University Press (OUP)
Published: 2011-11-10
Volume: 37
Issue: 3
Pages: 282-291
ISSN: 0146-8693 (ISSN-L)
1465-735X
DOI: 10.1093/jpepsy/jsr092
PMC: PMC3306169
OpenAlex: W2142245641
Cited by: 143
References: 53
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 16 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 3
FWCI: 7.65
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Pediatric Psychology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Procter and Gamble
National Institutes of Health (5ul1rr026314-03, UL1TR000077, 1UL1RR026314)
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK079037)
National Center for Research Resources (1UL1RR026314, UL1-RR026314)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Adolescent and Pediatric Healthcare
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: inflammatory bowel disease, adolescents, medication adherence, barriers to adherence, anxiety symptoms, depressive symptoms, psychosocial factors, pediatric inflammatory bowel disease
MeSH terms: Adolescent, Adolescent Behavior, Anxiety, Colitis, Ulcerative, Crohn Disease, Depression, Female, Humans, Male, Severity of Illness Index, Inflammatory Bowel Diseases, Medication Adherence, Checklist

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Treatment Adherence in Adolescents With Inflammatory Bowel Disease: The Collective Impact of Barriers to Adherence and Anxiety/Depressive Symptoms

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