Cited by 60Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsFrailty in Older Adults

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A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium

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Abstract

Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases prevalent in the elderly population. China, home to the world’s largest aging population, faces an escalating challenge in addressing the prevention and management of these age-related conditions. To meet this challenge, the Aging Biomarker Consortium of China has developed an expert consensus on biomarkers of vascular aging (VA) by synthesizing literature and insights from scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with VA and presents a systemic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the expert panel recommends the most clinically relevant VA biomarkers. For the functional domain, biomarkers reflecting vascular stiffness and endothelial function are highlighted. The structural dimension encompasses metrics for vascular structure, microvascular structure, and distribution. Additionally, proinflammatory factors are emphasized as biomarkers with the humoral dimension. The aim of this expert consensus is to establish a foundation for assessing the extent of VA and conducting research related to VA, with the ultimate goal of improving the vascular health of the elderly in China and globally.

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Crossref · 10.1093/lifemedi/lnad033

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Figure 1. Framework of biomarkers for vascular aging. The proposed framework for vascular aging (VA) consists of three dimensions: functional, structural, and humoral biomarkers. The most recommended VA biomarkers (Table 3) shown in red letters cover multidimensional and multiscale changes in the vasculature during aging and could be widely used in routine clinical practice. The value of these VA biomarkers in assessing the biological aging of the vasculature needs to be further validated. The human circulation image is licensed for use by veer website. Abbreviations: ABI, ankle brachial index; CACS, coronary artery calcium scores; CAVI, cardio-ankle vascular index; CBF, cerebral blood flow; CBV, cerebral blood volume; CFR, coronary flow reserve; cIMT, carotid intima-media thickness; CTA, computed tomography angiography; CVR, cerebrovascular reserve; DNAmAge, DNA methylation age; EMPs, endothelial microparticles; EPCs, endothelial progenitor cells; ePWV, estimated pulse wave velocity; FE, fundoscopic examination; FGF21, fibroblast growth factor 21; FMD, flow-mediated dilation; HERVK-Env, human endogenous retroviruse K envelope protein; IGF-1, insulin-like growth factor 1; IgG, immunoglobulin G; IMR, index of microcirculatory resistance; LSCI, laser speckle contrast imaging; MRA, magnetic resonance angiography; PP, pulse pressure; OCT, optical coherence tomography; PWV, pulse wave velocity; QSM, quantitative susceptibility mapping; RHI, reactive hyperemia index; SNAP, simultaneous noncontrast angiography and intraplaque hemorrhage; ufPWV, ultrafast ultrasound imaging pulse wave velocity; VWMRI, vessel wall magnetic resonance imaging.
Figure 1. Framework of biomarkers for vascular aging. The proposed framework for vascular aging (VA) consists of three dimensions: functional, structural, and humoral biomarkers. The most recommended VA biomarkers (Table 3) shown in red letters cover multidimensional and multiscale changes in the vasculature during aging and could be widely used in routine clinical practice. The value of these VA biomarkers in assessing the biological aging of the vasculature needs to be further validated. The human circulation image is licensed for use by veer website. Abbreviations: ABI, ankle brachial index; CACS, coronary artery calcium scores; CAVI, cardio-ankle vascular index; CBF, cerebral blood flow; CBV, cerebral blood volume; CFR, coronary flow reserve; cIMT, carotid intima-media thickness; CTA, computed tomography angiography; CVR, cerebrovascular reserve; DNAmAge, DNA methylation age; EMPs, endothelial microparticles; EPCs, endothelial progenitor cells; ePWV, estimated pulse wave velocity; FE, fundoscopic examination; FGF21, fibroblast growth factor 21; FMD, flow-mediated dilation; HERVK-Env, human endogenous retroviruse K envelope protein; IGF-1, insulin-like growth factor 1; IgG, immunoglobulin G; IMR, index of microcirculatory resistance; LSCI, laser speckle contrast imaging; MRA, magnetic resonance angiography; PP, pulse pressure; OCT, optical coherence tomography; PWV, pulse wave velocity; QSM, quantitative susceptibility mapping; RHI, reactive hyperemia index; SNAP, simultaneous noncontrast angiography and intraplaque hemorrhage; ufPWV, ultrafast ultrasound imaging pulse wave velocity; VWMRI, vessel wall magnetic resonance imaging.CC BY · PubMed Central

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Metadata

Authors
Aging Biomarker Consortium, Zhang, L., Guo, J., Liu, Y., Sun, S., Liu, B., Yang, Q., Tao, J., Tian, X.-L., Pu, J., Hong, H., Wang, M., Chen, H.-Z., Ren, J., Wang, X., Liang, Z., Wang, Y., Huang, K., Zhang, W., Qu, J., Ju, Z., Liu, G.-H., Pei, G., Li, J., & Zhang, C.
Affiliations
  • Tongji Hospital (CN)
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • Capital Medical University (CN)
  • Jena University Hospital (DE)
  • Shenzhen University (CN)
  • Sun Yat-sen University (CN)
  • Nanchang University (CN)
  • Shanghai Jiao Tong University (CN)
  • Fujian Medical University (CN)
  • Chinese Academy of Sciences (CN)
  • Xijing Hospital (CN)
  • ShenZhen People’s Hospital (CN)
  • Wuhan Union Hospital (CN)
  • Jinan University (CN)
  • Tongji University (CN)
Corresponding author
  • Liu, Baohua
  • Yang, Qi
  • Tao, Jun
  • Tian, Xiao-Li
  • Pu, Jun
  • Hong, Huashan
  • Wang, Miao
  • Chen, Hou-Zao
  • Ren, Jie
  • Wang, Xiaoming
  • Liang, Zhen
  • Wang, Yuan
  • Huang, Kai
  • Zhang, Weiqi
  • Qu, Jing
  • Ju, Zhenyu
  • Liu, Guang-Hui
  • Pei, Gang
  • Li, Jian
  • Zhang, Cuntai
Venue
Life Medicine
Published
2023-08-01
Volume
2
Issue
4
Pages
lnad033-lnad033
ISSN
2755-1733 (ISSN-L)
OpenAlex
W4386274160
Cited by
60
References
221
Citations by year
2026: 15 · 2025: 24 · 2024: 17 · 2023: 4
FWCI
11.79
Type
journal article
Language
en
Open access
Locations
  • Life Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Key Research and Development Program of China (2020YFC2008000, 2022YFA1103700)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
vascular aging, biomarkers, vascular stiffness, endothelial function, microvascular structure, pro-inflammatory factors, age-related chronic diseases

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