The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
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In the citing paper
“Proapoptotic proteins, including Bak, Bax, Bid, Puma, and Noxa, are transactivated by p53, which induces apoptosis.35,100,101”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [35]
In the citing paper
“p53 causes apoptosis through transcriptional activation of the expression of the pro-apoptotic genes, such as Puma, Bax and Noxa.68–70”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [70]
In the citing paper
“Upon DNA binding, the DBD and the DNA helix undergo structural changes.”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [70]
In the citing paper
“Two DBDs bind each decameric half-site as a symmetrical dimer (A-B), and two such dimers (A-B and C-D) constitute a tetramer on a full DNA response element via protein-protein and base stacking interactions.11,70,295–299”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [70]
In the citing paper
“p53 binds to a full consensus DNA response element as a tetramer through a highly cooperative self-assembling mechanism (Fig. 7b).”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [70]
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Citations
Cites
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Blinded by the Light: The Growing Complexity of p53
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Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
Transcriptional control of human p53-regulated genes
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
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“This mechanism has been observed for the binding of the homomeric glucocorticoid receptor to a DNA target with an additional 1-bp insertion (10).”
BackgroundA Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
DNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673
Self-citationTranscriptional Regulation by P53
Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569
Coping with stress: multiple ways to activate p53
Horn, H. F., & Vousden, K. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210263 · Cited by 522 · cited 1×
“The tumor suppressor protein p53 plays an essential role in preventing cancer development (1,2).”
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Self-citationAbsence of a simple code: how transcription factors read the genome
Slattery, M., Zhou, T., Yang, L., Dantas Machado, A. C., Gordân, R., & Rohs, R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.07.002 · Cited by 537
Self-citationHuang, Y., Liu, N., Liu, J., Liu, Y., Zhang, C., Long, S., Luo, G., Zhang, L., & Zhang, Y. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1688951 · Cited by 94
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
PDBminer to Find and Annotate Protein Structures for Computational Analysis
Degn, K., Beltrame, L., Tiberti, M., & Papaleo, E. (2023) · doi:10.1101/2023.05.06.539447 · Cited by 6
Metadata
- Authors
- Chen, Y., Zhang, X., Dantas Machado, A. C., Ding, Y., Chen, Z., Qin, P. Z., Rohs, R., & Chen, L.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-02
- Volume
- 41
- Issue
- 17
- Pages
- 8368-8376
- ISSN
- 1362-4962
- 0305-1048
- Cited by
- 78
- References
- 11
- Language
- en
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- Chen, Y., Zhang, X., Dantas Machado, A. C., Ding, Y., Chen, Z., Qin, P. Z., Rohs, R., & Chen, L. (2013). Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt584
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