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Discovering the 3′ UTR-mediated regulation of alpha-synuclein
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The protein lists from this study and Marchese et al. overlapped on only three proteins: Sub1/TCP4, HNRNPA1/ROA1, and ELAVL1/ELAV1.
“The protein lists from these two studies only overlapped on three proteins, Sub1/TCP4, HNRNPA1/ROA1, and ELAVL1/ELAV1, reflecting the different experimental approaches used.”
From RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts (2023) · cites this paper as [30]
Marchese et al. identified 27 top RBPs binding SNCA mRNA by in vitro protein library screening, prioritized ELAVL1 and TIAR, and showed TIAR positively regulates SNCA mRNA translation.
“To identify RBPs that bind SNCA mRNA, Marchese et al. first reported an in vitro protein library screening, identifying 27 top interactors. They prioritized focus on two RBPs, ELAVL1 and TIAR, and showed that TIAR, in particular, positively regulated SNCA mRNA translation [30].”
From RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts (2023) · cites this paper as [30]
ELAVL1 binds the SNCA 3′UTR, and AUF1 competes with HuR for binding to specific U/AU-rich motifs in other mRNA targets.
“given that ELAVL1 binds SNCA 3′UTR [30] and AUF1 has been shown to compete with HuR for binding to specific U/AU-rich motifs in other mRNA targets [36,37]”
From RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts (2023) · cites this paper as [30]
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Cites
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 3,971 · cited 1×
“Using the PhastCons score to measure evolutionary conservation of sequence blocks across multiple vertebrates (44), we separated the microRNAs in two classes: conserved (PhastCons score > 0.”
MethodInternational Parkinson's Disease Genomics Consortium (IPDGC), Nalls, M. A., Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Investigator, T. A. J. D., (CHARGE), C. F. H. A. A. R. I. G. E., North American Brain Expression Consortium (NABEC), et al. (2014) · Nature Genetics · doi:10.1038/ng.3043 · Cited by 1,895
A novel function for fragile X mental retardation protein in translational activation
Bechara, E. G., Didiot, M. C., Melko, M., Davidovic, L., Bensaid, M., Martin, P., Castets, M., Pognonec, P., Khandjian, E. W., Moine, H., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000016 · Cited by 206 · cited 1×
“The RNA electrophoretic mobility shift assay and the competition assay were performed as previously described (11) (see Supplementary Materials for details).”
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Cited by
Sorted by citations
Kattan, F.-G., Koukouraki, P., Anagnostopoulos, A. K., Tsangaris, G. T., & Doxakis, E. (2023) · Open Biology · doi:10.1098/rsob.230158 · Cited by 18
Metadata
- Authors
- Marchese, D., Botta-Orfila, T., Cirillo, D., Rodriguez, J. A., Livi, C. M., Fernández-Santiago, R., Ezquerra, M., Martí, M. J., Bechara, E., Tartaglia, G. G., Catalan MSA Registry (CMSAR), Ávila, A., Bayés, À., Botta-Orfila, T., Caballol, N., Calopa, M., Campdelacreu, J., Compta, Y., Ezquerra, M., de Fàbregues, O., Fernández-Santiago, R., Girado, D., Hernández-Vara, J., Jaumà, S., Marchese, D., Martí, M. J., Pagonabarraga, J., Pastor, P., Planellas, L., Pont-Sunyer, C., Puente, V., Pujol, M., Saura, J., Tartaglia, G. G., Tolosa, E., & Valldeoriola, F.
- Affiliations
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain
- Universitat Pompeu Fabra (UPF), Barcelona, Spain
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-11-15
- Volume
- 45
- Issue
- 22
- Pages
- 12888-12903
- ISSN
- 0305-1048
- 1362-4962
- PMC
- PMC5728410
- Cited by
- 45
- References
- 4
- Language
- en
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