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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

Doxakis, Epaminondas·2010·Journal of Biological Chemistry
DOI 10.1074/jbc.m109.086827
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Abstract

Genetic and biochemical studies have established a central role for alpha-synuclein accumulation in the pathogenesis of Parkinson disease. Here, two microRNAs, namely mir-7 and mir-153, have been identified to regulate alpha-synuclein levels post-transcriptionally. These microRNAs bind specifically to the 3'-untranslated region of alpha-synuclein and down-regulate its mRNA and protein levels, with their effect being additive. They are expressed predominantly in the brain with a pattern that mirrors synuclein expression in different tissues as well as during neuronal development, indicating that they play a tuning role in the amount of alpha-synuclein produced. Overexpression of mir-7 and mir-153 significantly reduces endogenous alpha-synuclein levels, whereas inhibition of mir-7 and mir-153 enhances translation of a luciferase construct bearing the alpha-synuclein 3'-untranslated region in primary neurons. These findings reveal a significant additional mechanism by which alpha-synuclein is regulated and point toward new therapeutic regimes for lowering endogenous alpha-synuclein levels in patients with familial or sporadic Parkinson disease.

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Crossref · 10.1074/jbc.m109.086827

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  • One SNCA SNP (rs17016074) increases transcript levels by >30%, and the other resides within a functional miR-153 binding site.

    “SNCA encodes alpha-synuclein, a component of the pathogenic aggregates observed in Parkinson's disease, and one of these SNPs (rs17016074) increases transcript levels by >30% (Sotiriou et al., 2009), whereas the other resides within a functional miR-153 binding site (Doxakis, 2010).”

    From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Doxakis, 2010

Citations

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Metadata

Authors
Doxakis, E.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2010-04
Volume
285
Issue
17
Pages
12726-12734
ISSN
0021-9258
DOI
10.1074/jbc.m109.086827
Cited by
454
References
5
Language
en
Licence

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