Age at Smoking Onset and the Onset of Depression and Anxiety Disorders
Abstract
INTRODUCTION: Smoking is a known risk indicator for depression and some of the anxiety disorders. No data are available on the role of age at smoking onset in the development of depression and anxiety disorders. We examined the association of smoking onset age on the onset age of depression and anxiety disorders. METHODS: Participants of the Netherlands Study of Depression and Anxiety Disorders who developed psychopathology after starting smoking were selected (N = 1,055). The dependent variable was the time to onset of psychopathology after starting smoking, and the independent variable was age at smoking onset. RESULTS: The time period between smoking onset and the onset of depression and/or anxiety disorders was 5 years shorter for early-onset smokers than for late-onset smokers. Moreover, a greater percentage of early-onset smokers than late-onset smokers had the first onset of psychopathology within the first 5 years after starting smoking. Age at smoking onset predicted age at psychopathology onset after controlling for the effects of gender, education, and childhood trauma. When separate analyses were done for depression and anxiety disorders, this pattern of results was found only for anxiety disorders. CONCLUSIONS: A young age at smoking onset is associated with a shorter time to first onset of an anxiety disorder. This study with psychiatric patients extends previous findings in general population samples that smoking and depression and anxiety disorders are associated.
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Cigarette smoking in adolescence is associated with a shorter time to onset of anxiety disorders.
“and is also associated with a shorter time to onset of anxiety disorders [12].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [12]
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Reynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26 · see citing works
“…which include generalized anxiety disorder, panic disorder, and post-traumatic stress disorder, in early adulthood, even after controlling for the presence of anxiety and depressive disorders in adolescence [11], and is also associated with a shorter time to onset of anxiety disorders [12].”
Reynolds, L. M., Gulmez, A., Fayad, S. L., Campos, R. C., Rigoni, D., Nguyen, C., Le Borgne, T., Topilko, T., Rajot, D., Franco, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53327-w · Cited by 10 · see citing works
- Authors
- Jamal, M., Does, A. J. W. V. D., Penninx, B. W. J. H., & Cuijpers, P.
- Affiliations
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Vrije Universiteit Amsterdam (NL)
- Venue
- Nicotine & Tobacco Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-05-04
- Volume
- 13
- Issue
- 9
- Pages
- 809-819
- ISSN
- 1462-2203 (ISSN-L)
- 1469-994X
- OpenAlex
- W2129303195
- Cited by
- 55
- References
- 98
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nicotine & Tobacco Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- VU Research Portal (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- smoking initiation age, depression, anxiety disorders, early smoking onset, time to onset, psychiatric patients, childhood trauma
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Child, Depressive Disorder, Female, Humans, Longitudinal Studies, Male, Middle Aged, Netherlands, Smoking, Cohort Studies, Age of Onset, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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