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The psychological impact of COVID-19 on the mental health in the general population
Open accessAbstract
As a result of the emergence of coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Chinese city of Wuhan, a situation of socio-economic crisis and profound psychological distress rapidly occurred worldwide. Various psychological problems and important consequences in terms of mental health including stress, anxiety, depression, frustration, uncertainty during COVID-19 outbreak emerged progressively. This work aimed to comprehensively review the current literature about the impact of COVID-19 infection on the mental health in the general population. The psychological impact of quarantine related to COVID-19 infection has been additionally documented together with the most relevant psychological reactions in the general population related to COVID-19 outbreak. The role of risk and protective factors against the potential to develop psychiatric disorders in vulnerable individuals has been addressed as well. The main implications of the present findings have been discussed.
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“Factors such as a previous psychiatric diagnosis, isolation, financial distress, hopelessness, loneliness and uncertainty due to COVID-19 outbreaks can also increase the risk of psychiatric conditions and suicide.(Killgore et al., 2020a; Serafini et al., 2020; Xin et al., 2020; Serafini et al., 2012)”
From Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: a global cross-sectional survey (2021) · cites this paper as Serafini et al., 2020
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“In contrast, resilience and perception of social support can be protective against psychiatric disorders.(Serafini et al., 2020)”
From Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: a global cross-sectional survey (2021) · cites this paper as Serafini et al., 2020
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“This has led to a steep reduction in social contact which is likely to have increased experiences of loneliness and may have increased psychological distress (Barari et al., 2020; Serafini et al., 2020; Liu et al., 2020; Ellis et al., 2020).”
From Loneliness, social relationships, and mental health in adolescents during the COVID-19 pandemic (2021) · cites this paper as Serafini et al., 2020
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“A major reason for using convenience sampling is the post-covid situation where people are maintaining social distancing and avoiding direct physical interaction with other people (Serafini et al., 2020).”
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Covid-19’un OECD Ülkeleri ve Çin’de Makroekonomik Etkisinin Kümeleme Analizi
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COVID-19 associated social stigma as experienced by frontline nurses of Hail: A qualitative study
Alsaqri, S. (2021) · International Journal of ADVANCED AND APPLIED SCIENCES · doi:10.21833/ijaas.2021.08.007 · Cited by 5
“Researchers discussed that since COVID-19 is a new disease, health institutions were not prepared for its impact in the health care setting which resulted in health workers’ psychological and emotional devastation leading to mental instability (Serafini et al., 2020; Alkhamees et al., 2020; Jimeno, 2020).”
BackgroundCOVID-19 Salgını Sonrasında Yapılı Çevrenin Fiziksel ve Kavramsal Dönüşümü Üzerine Öngörüler
ENSARİOĞLU, S. A. (2021) · İDEALKENT · doi:10.31198/idealkent.871661 · Cited by 5
Gambaran Psikologis Remaja SMA Selama Sekolah dari Rumah Akibat Pandemi COVID-19 di Indonesia
Andini, M., & Pudjiati, S. R. R. (2021) · Psikostudia Jurnal Psikologi · doi:10.30872/psikostudia.v10i3.5267 · Cited by 5
Weatherall, A., Tennent, E., & Grattan, F. (2022) · Discourse & Society · doi:10.1177/09579265211048732 · Cited by 5
“High levels of stress, anxiety and depression are being documented around the world (Serafini et al., 2020).”
BackgroundMental Impact of COVID-19 – Fear, Stress, Anxiety, Depression and Sequels
Parchani, A., Panda, P. K., & Krishnan, V. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102754 · Cited by 5
Gong, W., Ju, G., Zhu, M., Wang, S., Guo, W., & Chen, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.753703 · Cited by 5
“Studies reveal that the level of distress or anxiety in population can significantly grow during a pandemic (10).”
BackgroundAlmeda, N., Díaz-Milanés, D., Gutiérrez-Colosía, M. R., & GARCÍA-ALONSO, C. R. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04257-8 · Cited by 5
Shamloo, S. E., Cocco, V. M., Visintin, E. P., Trifiletti, E., & Vezzali, L. (2022) · Journal of Applied Social Psychology · doi:10.1111/jasp.12926 · Cited by 5
“The new corona virus has caused several severe physical health issues, deaths as well as extreme indirect effects on individuals such as depression, anxiety, or loneliness due to the strict measures implemented by governments to reduce the spread of the virus (Serafini et al., 2020).”
BackgroundRandall, K. N., & McKown, G. L. (2022) · Journal of Intellectual Disabilities · doi:10.1177/17446295221146352 · Cited by 5
“…and offer mental healthcare opportunities for people with intellectual and developmental disability (Cullen et al., 2020; Dodd et al., 2017; Sera fi ni et al., 2020) to discuss mental health concerns (such as anxiety, fear, depression, anger) which have resulted from the current pandemic…”
BackgroundCarbonell, Á., Pérez, J. J. N., Fernández, I., & Botija, M. (2023) · Journal of Evidence-Based Social Work · doi:10.1080/26408066.2023.2171330 · Cited by 7
King, A. L., Acquaye, A., Vera, E. M., Mendoza, T. R., Reyes, J., Stockdill, M., Gilbert, M. R., & Armstrong, T. S. (2023) · BMC Cancer · doi:10.1186/s12885-023-10671-2 · Cited by 5
Between Boredom and Frustration: Predictor of Compulsive Internet Use
Utami, R. H., Magistarina, E., Pratama, M., & Khasanah, A. N. (2021) · Jurnal Neo Konseling · doi:10.24036/00617kons2021 · Cited by 5
“Several conditions such as disabling loneliness, specific and uncontrolled fear, pervasive anxiety, and frustration and boredom contribute to declined subjective well-being and have a more significant impact at a young age (Serafini et al., 2020).”
BackgroundAlKuwaiti, M., Hamada, B. A., Aljneibi, N., Paulo, M. S., & Elbarazi, I. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.866078 · Cited by 5
“(30) reviewed the literature and found that resilience, loneliness, anxiety, loss of freedom, and well-being were the main psychological effects of COVID-19 on communities (30).”
BackgroundRelationship between fear of COVID-19 and premenstrual syndrome in Turkish university students
Kaplan, S., Gürler, M., & Gönenç, İ. M. (2022) · Women & Health · doi:10.1080/03630242.2022.2103611 · Cited by 5
“Fear is related to the COVID-19 pandemic (Broche-Pérez et al. 2022; Serafini et al. 2020).”
BackgroundCOVID‐19: What if immunity wanes?
Çenesiz, M. A., & Guimarães, L. (2022) · Canadian Journal of Economics/Revue canadienne d économique · doi:10.1111/caje.12542 · Cited by 7
“Second, there are also other significant costs of constrained social activity such as anxiety, distress, fatigue, and domestic violence (Ravindran and Shah, 2020; Serafini et al., 2020).”
BackgroundSanabria‐Mazo, J. P., Gómez-Acosta, A., Muñoz, J. A. C., Rojas, Y. F., Feliu‐Soler, A., Luciano, J. V., & Sanz, A. (2021) · doi:10.31219/osf.io/r5tdh · Cited by 5
Černe, M., & Aleksić, D. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1042397 · Cited by 6
“In line with this model, we treat hidden work as a source of frustration, which stems from a superior source of frustration arising from environmental uncertainty and change (Serafini et al., 2020), where both act as enablers or inhibiters in achieving individual and organizational goals.”
BackgroundMethodAuz, A. J. V., Villarreal, S. D. R., González, J. L. A., Orellana, C. F. V., Andrade, R. E. C., Zabala, G. N. D. J. A., Vicens‐Blanes, F., & Molina‐Mula, J. (2024) · BMC Nursing · doi:10.1186/s12912-024-02119-0 · Cited by 9
“Previous studies in several countries, including France, Italy, and Spain, have highlighted the vulnerability of frontline health workers to the emotional impact of both the pandemic and its consequences [9].”
ResultElBarazi, A. S. (2025) · Journal of Public Health Research · doi:10.1177/22799036251347030 · Cited by 12
Clinical and Symptom Profiles of Long-COVID Patients in Italy: A Cross-Sectional Analysis
Cianciulli, A., Santoro, E., Manente, R., Pacifico, A., Barberio, I., Satriani, V., & Boccia, G. (2025) · Healthcare · doi:10.3390/healthcare13212706 · Cited by 4
“Fatigue, weakness, and musculoskeletal pain were most common, consistent with international findings [2,3,7–9 , 12– 14].”
Kakaje, A., Mansour, S., & Ghareeb, A. (2020) · Qatar medical journal · doi:10.5339/qmj.2021.17 · Cited by 5
Benzies, K., Perry, R. L., & Williams, J. C. (2021) · Social Work in Mental Health · doi:10.1080/15332985.2021.1975013 · Cited by 4
“Effects include fears related to exposure to the virus, financial losses, frustration, loneliness, and social isolation (Khan, Mamun, Griffiths, & Ullah, 2020; Serafini et al., 2020; Vigo et al., 2020).”
BackgroundYusuf, M. M., & Azhar, N. L. A. (2021) · Malaysian Journal of Science Health & Technology · doi:10.33102/mjosht.v7i2.213 · Cited by 4
Mastroberardino, M., Costantini, R. C., Novellis, A. M. P. D., Ferrari, S., Filippini, C., Longo, F., Marchi, M., Rioli, G., Valeo, L., Vicini, R., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127313 · Cited by 6
“The COVID-19 pandemic has also conveyed a large psycho-social backlash [9,10], particularly impacting the most vulnerable fringes of society, such as the elders, children, teenagers, and people with pre-existing physical or psychological diseases [11,12].”
BackgroundKo, H., Shin, J. H., & Cooper, L. D. (2022) · Assessment · doi:10.1177/10731911221115144 · Cited by 4
“…pandemic, there is a possibility that the pandemic affected and increased overall mental health distress in these populations, in line with the growing research of pandemic’s negative influence on mental health (Horigian et al., 2021; Islam et al., 2021; Pierce et al., 2020; Serafini et al., 2020).”
ResultThe Impact of COVID-19 on the Emotion of People Living with and without HIV
Lusher, J. M., Zúñiga, R. A. A., Virtanen, J. I., Ellakany, P., Yousaf, M. A., Osamika, B. E., Gaffar, B. O., Lawal, F. B., Khalid, Z., Aly, N. M., et al. (2023) · Hygiene · doi:10.3390/hygiene3010005 · Cited by 5
“Moreover, these factors have compounded feelings of frustration [4,5], boredom [6], loneliness [7–10], anger [11], grief [12], loss [13], anxiety, and depression [14,15] for individuals on a worldwide scale, and, in particular, for those living with chronic conditions [16].”
BackgroundZhang, W., Ding, L., Jin, Y., & Song, W. (2023) · Psychology · doi:10.4236/psych.2023.142017 · Cited by 4
Berryhill, M. B., Horton, A. G., Masters, S. L., Mack, D. R., Cross, A. N., Parker, J. G., Barth, J. M., & McDonald, K. L. (2023) · The Journal of Early Adolescence · doi:10.1177/02724316231178687 · Cited by 4
THE IMPACT OF QUARANTINE AND SOCIAL ISOLATION ON THE MENTAL STATE OF THE POPULATION
Іваніцька, Т. І. (2023) · Bukovinian Medical Herald · doi:10.24061/2413-0737.27.1.105.2023.12 · Cited by 4
“Проте дослідження, пов’язані з подоланням стресу, показують, що дві функції подолання часто співіснують [21].”
Fox, A. B., Baier, A. L., Alpert, E., Nillni, Y. I., & Galovski, T. E. (2023) · Journal of Women s Health · doi:10.1089/jwh.2023.0078 · Cited by 4
Health professionals who have worked in COVID-19 immunization centers suffer the effects of violence
Brunelli, L., Scarpis, E., Presti, T. L., Fiorillo, F., Campanella, F., Zuliani, P., Farneti, F., Croci, E., Pellizzari, B., Cocconi, R., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1264301 · Cited by 4
“The impact of COVID-19 on the mental health of the general population is widely recognized (12), and has been called the perfect storm for mental health by some colleagues (13).”
Der, T., Helmke, N., Stout, J. E., & Turner, N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293831 · Cited by 4
Zhu, P., Wang, W. C., Qian, M., Shi, G., Zhang, Q., Xu, T., Xu, H., Zhang, H., Gu, X., Ding, Y., et al. (2023) · Healthcare · doi:10.3390/healthcare12010019 · Cited by 6
“Our findings support existing studies linking a steep reduction in social contact with increased experiences of loneliness and potential psychological distress [10,27].”
ResultGiosa, R. (2024) · International Journal of Sociology and Social Policy · doi:10.1108/ijssp-03-2023-0081 · Cited by 5
Metadata
- Authors
- Serafini, G., Parmigiani, B., Amerio, A., Aguglia, A., Sher, L., & Amore, M.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- James J. Peters VA Medical Center (US)
- Corresponding author
- Serafini, G
- Venue
- QJM: An International Journal of Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-06-30
- Volume
- 113
- Issue
- 8
- Pages
- 531-537
- ISSN
- 0033-5622 (ISSN-L)
- 1460-2725
- 1460-2393
- PMC
- PMC7337855
- OpenAlex
- W3036526826
- Cited by
- 1,187
- References
- 40
- Citations by year
- 2026: 19 · 2025: 61 · 2024: 117 · 2023: 208 · 2022: 312 · 2021: 390 · 2020: 77
- FWCI
- 98.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- QJM (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Funders
- DINOGMI Department of Excellence of MIUR (2018-2022, 232/2016)
- Topics
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- COVID-19 pandemic, mental health, psychological distress, anxiety, depression, stress, uncertainty, quarantine, risk factors, protective factors, mental illness, general population
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