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Impact of COVID-19 pandemic on mental health in the general population: a systematic review

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Xiong, Jiaqi, Lipsitz, Orly, Nasri, Flora, Lui, Leanna M.W., Gill, Hartej, Phan, Lee, Chen-Li, David, Iacobucci, Michelle +3 more·2020·Journal of Affective Disorders

Abstract

Background As a major virus outbreak in the 21st century, the Coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented hazards to mental health globally. While psychological support is being provided to patients and healthcare workers, the general public's mental health requires significant attention as well. This systematic review aims to synthesize extant literature that reports on the effects of COVID-19 on psychological outcomes of the general population and its associated risk factors.Methods A systematic search was conducted on PubMed, Embase, Medline, Web of Science, and Scopus from inception to 17 May 2020 following the PRISMA guidelines. A manual search on Google Scholar was performed to identify additional relevant studies. Articles were selected based on the predetermined eligibility criteria.Results Relatively high rates of symptoms of anxiety (6.33% to 50.9%), depression (14.6% to 48.3%), post-traumatic stress disorder (7% to 53.8%), psychological distress (34.43% to 38%), and stress (8.1% to 81.9%) are reported in the general population during the COVID-19 pandemic in China, Spain, Italy, Iran, the US, Turkey, Nepal, and Denmark. Risk factors associated with distress measures include female gender, younger age group (≤40 years), presence of chronic/psychiatric illnesses, unemployment, student status, and frequent exposure to social media/news concerning COVID-19.Limitations A significant degree of heterogeneity was noted across studies.Conclusions The COVID-19 pandemic is associated with highly significant levels of psychological distress that, in many cases, would meet the threshold for clinical relevance. Mitigating the hazardous effects of COVID-19 on mental health is an international public health priority.

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Crossref · 10.1016/j.jad.2020.08.001

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  • Cross-sectional data collected early in the pandemic suggested that college students were disproportionately affected by stress, depression, anxiety, and loneliness due to reduced social interactions, lack of social support, and newly arising stressors associated with the COVID-19 crisis.

    “Cross-sectional data collected early in the pandemic period suggested that college students were disproportionately affected by stress, depression, anxiety, and loneliness due to reduced social interactions, lack of social support, and newly arising stressors associated with the COVID-19 crisis [28, 34–37].”

    From Psychological correlates of perceived loneliness in college students before and during the COVID-19 stay-at-home period: a longitudinal study (2023) · cites this paper as [37]

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  • During the COVID-19 pandemic, reported rates of depression in general populations ranged from 14.6% to 48.3%.

    “A growing body of evidence has demonstrated the clinical effects of the COVID-19 pandemic on mental health, including higher rates of depression (14.6-48.3%), anxiety (6.3-50.9%), and stress (8.1-81.9%) [2,5,6].”

    From Depression, anxiety, and stress in Korean general population during the COVID-19 pandemic. (2022) · cites this paper as [5]

    The Results section ('Symptoms of depression and associated risk factors') reports the exact 14.6%–48.3% range for depressive symptoms in the reviewed studies. It explicitly cautions that depressive symptoms do not constitute a clinical diagnosis of depression, so the citing sentence's unqualified reference to rates of depression overstates the finding. (LLM, conf=0.84)

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  • Single subjects are more likely to feel loneliness and isolation than married couples, which may explain their higher levels of stress, anxiety, and depression.

    “Single subjects are certainly more likely to feel the effects of loneliness and isolation than married couples, which may explain their consistently higher levels of stress, anxiety, and depression [5,27].”

    From Depression, anxiety, and stress in Korean general population during the COVID-19 pandemic. (2022) · cites this paper as [5]

    The Results section on depression lists both being single and high loneliness as risk factors for depressive symptoms. It does not establish that single people are lonelier than married people or that loneliness explains their symptoms. The stress results do not identify single status as a risk factor, and the anxiety results report one study in which married participants had higher anxiety than unmarried participants. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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  • According to the WHO, MDD is the single largest contributor to loss of healthy life, and this contribution has apparently further increased during the COVID-19 pandemic.

    “According to the World Health Organization (WHO), MDD is the ­ sin­ gle largest contributor to loss of healthy life, and this contribution has apparently fur­ ­ ther increased during the COVID-­ 19 pandemic 6-­ 8 .”

    From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [8]

    The Results section (‘Symptoms of depression and associated risk factors’; page not provided) reports higher rates of depressive symptoms during the pandemic than pre-pandemic estimates. It explicitly cautions that depressive symptoms do not establish a clinical diagnosis. The paper does not support the WHO ranking or show that MDD’s contribution to loss of healthy life increased. (LLM, conf=0.87)

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  • The presence of an acquaintance infected with COVID-19 in the immediate environment is one of the predictive factors of depression.

    “The presence of an acquaintance infected with COVID-19 in the immediate environment is one of the predictive factors of depression (Ghazawy et al. 2020, Hyland et al. 2020, Xiong et al. 2020).”

    From DETERMINING THE RELATIONSHIP BETWEEN HEALTH TECHNICIAN STUDENTS' ATTITUDES TO THE COVID-19 PANDEMIC AND INTOLERANCE OF UNCERTAINTY WITH DEPRESSION, ANXIETY, AND STRESS LEVELS (2023) · cites this paper as Xiong et al. 2020

    The Results section (‘Symptoms of depression and associated risk factors’) lists having an acquaintance infected with COVID-19 among predictive factors for depressive symptoms. It does not establish that the acquaintance was in the person’s immediate environment, and the same section cautions that depressive symptoms are not a clinical diagnosis of depression. (LLM, conf=0.86)

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  1. Statistic Canada, 2020. Labour force characteristics, monthly, seasonally adjusted and trend-cycle, last 5 months. https://doi.org/10.25318/1410028701-eng(Accessed June 12 2020,). · DOI

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Authors
Xiong, J., Lipsitz, O., Nasri, F., Lui, L. M. W., Gill, H., Phan, L., Chen-Li, D., Iacobucci, M., Ho, R., Majeed, A., & McIntyre, R. S.
Affiliations
  • University of Toronto (CA)
  • University Health Network (CA)
  • National University of Singapore (SG)
Corresponding author
McIntyre, Roger S.
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2020-12
Volume
277
Pages
55-64
ISSN
0165-0327 (ISSN-L)
OpenAlex
W3047898105
Cited by
5,204
References
58
Citations by year
2026: 218 · 2025: 404 · 2024: 693 · 2023: 1041 · 2022: 1406 · 2021: 1306 · 2020: 125 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2
FWCI
76.78
Type
journal article
Language
en
Open access
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
  • Shire
  • H. Lundbeck A/S
  • Stanley Medical Research Institute
  • Janssen Canada
Topics
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
COVID-19 pandemic, mental health, general population, anxiety, depression, post-traumatic stress disorder, psychological distress, stress, risk factors, social media exposure, unemployment, chronic disease, gender differences, age differences
MeSH terms
Betacoronavirus, Psychological Distress, COVID-19, SARS-CoV-2, Age Factors, Anxiety, China, Denmark, Depression, Humans, Iran, Italy, Mental Health, Nepal, Pneumonia, Viral, Sex Factors, Spain, Stress Disorders, Post-Traumatic, Stress, Psychological, Turkey, Unemployment, United States, Coronavirus, Coronavirus Infections, Pandemics, Social Media

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