Cited by 47Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

Self-referential processing influences functional activation during cognitive control: An fMRI study

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Wagner, Gerd, Koch, Kathrin, Schachtzabel, Claudia, Peikert, Gregor, Schultz, Carl Christoph, Reichenbach, Jürgen R., Sauer, Heinrich, Schlösser, Ralf G.·2013·Social Cognitive and Affective Neuroscience

Abstract

Rostral anterior cingulate cortex (rACC) plays a central role in the pathophysiology of major depressive disorder (MDD). As we reported in our previous study (Wagner et al., 2006), patients with MDD were characterized by an inability to deactivate this region during cognitive processing leading to a compensatory prefrontal hyperactivation. This hyperactivation in rACC may be related to a deficient inhibitory control of negative self-referential processes, which in turn may interfere with cognitive control task execution and the underlying fronto-cingulate network activation. To test this assumption, a functional magnetic resonance imaging study was conducted in 34 healthy subjects. Univariate and functional connectivity analyses in statistical parametric mapping software 8 were used. Self-referential stimuli and the Stroop task were presented in an event-related design. As hypothesized, rACC was specifically engaged during negative self-referential processing (SRP) and was significantly related to the degree of depressive symptoms in participants. BOLD signal in rACC showed increased valence-dependent (negative vs neutral SRP) interaction with BOLD signal in prefrontal and dorsal anterior cingulate regions during Stroop task performance. This result provides strong support for the notion that enhanced rACC interacts with brain regions involved in cognitive control processes and substantiates our previous interpretation of increased rACC and prefrontal activation in patients during Stroop task.

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Crossref · 10.1093/scan/nss074

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Authors
Wagner, G., Koch, K., Schachtzabel, C., Peikert, G., Schultz, C. C., Reichenbach, J. R., Sauer, H., & Schlösser, R. G.
Affiliations
Jena University Hospital (DE)
Corresponding author
Wagner, Gerd
Venue
Social Cognitive and Affective Neuroscience
Published
2012-07-13
Volume
8
Issue
7
Pages
828-837
ISSN
  • 1749-5016 (ISSN-L)
  • 1749-5024
OpenAlex
W2152056067
Cited by
47
References
47
Citations by year
2026: 5 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders
Bundesministerium für Bildung und Forschung (01GW0740)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
rostral anterior cingulate cortex, self-referential processing, cognitive control, major depressive disorder, Stroop task, prefrontal cortex, dorsal anterior cingulate cortex, inhibitory control, functional connectivity
MeSH terms
Adolescent, Adult, Brain Mapping, Cognition, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Self Concept, Task Performance and Analysis, Young Adult

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