Self-referential processing influences functional activation during cognitive control: An fMRI study
Open accessAbstract
Rostral anterior cingulate cortex (rACC) plays a central role in the pathophysiology of major depressive disorder (MDD). As we reported in our previous study (Wagner et al., 2006), patients with MDD were characterized by an inability to deactivate this region during cognitive processing leading to a compensatory prefrontal hyperactivation. This hyperactivation in rACC may be related to a deficient inhibitory control of negative self-referential processes, which in turn may interfere with cognitive control task execution and the underlying fronto-cingulate network activation. To test this assumption, a functional magnetic resonance imaging study was conducted in 34 healthy subjects. Univariate and functional connectivity analyses in statistical parametric mapping software 8 were used. Self-referential stimuli and the Stroop task were presented in an event-related design. As hypothesized, rACC was specifically engaged during negative self-referential processing (SRP) and was significantly related to the degree of depressive symptoms in participants. BOLD signal in rACC showed increased valence-dependent (negative vs neutral SRP) interaction with BOLD signal in prefrontal and dorsal anterior cingulate regions during Stroop task performance. This result provides strong support for the notion that enhanced rACC interacts with brain regions involved in cognitive control processes and substantiates our previous interpretation of increased rACC and prefrontal activation in patients during Stroop task.
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The dmPFC and ACC form a continuum in coding information for self-relevance in both cognitive and emotional domains.
“It has been proposed by Northoff et al. [2006] that the dmPFC and ACC form a continuum in coding information for self-relevance in both cognitive and emotional domains [Northoff et al., 2006;Wagner et al., 2013].”
From Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses: Oxytocin Blurs Self-Other Distinction (2016) · cites this paper as Wagner et al., 2013
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- Authors
- Wagner, G., Koch, K., Schachtzabel, C., Peikert, G., Schultz, C. C., Reichenbach, J. R., Sauer, H., & Schlösser, R. G.
- Affiliations
- Jena University Hospital (DE)
- Corresponding author
- Wagner, Gerd
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-13
- Volume
- 8
- Issue
- 7
- Pages
- 828-837
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC3791071
- OpenAlex
- W2152056067
- Cited by
- 47
- References
- 47
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01GW0740)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- rostral anterior cingulate cortex, self-referential processing, cognitive control, major depressive disorder, Stroop task, prefrontal cortex, dorsal anterior cingulate cortex, inhibitory control, functional connectivity
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cognition, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Self Concept, Task Performance and Analysis, Young Adult
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