N eural and behavioral correlates of negative self‐focused thought associated with depression
Open accessAbstract
A central feature of major depression (MDD) is heightened negative self‐focused thought (negative‐SFT). Neuroscientific research has identified abnormalities in a network of brain regions in MDD, including brain areas associated with SFT such as medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). To our knowledge no studies have investigated the behavioral and neural correlates of negative‐SFT using a sentence completion task in a sample of individuals with varying depression histories and severities. We test the following hypotheses: (1) negative‐SFT will be associated with depression; and (2) depression and negative‐SFT will be related to resting‐state functional connectivity (rsFC) for brain regions implicated in SFT. Seventy‐nine women with varying depression histories and severities completed a sentence completion task and underwent resting‐state functional magnetic resonance imaging (rs‐fMRI). Standard seed‐based voxelwise rsFC was conducted for self‐network regions of interest: dorsomedial PFC (dmPFC) and pregenual ACC (pgACC). We performed linear regression analyses to examine the relationships among depression, negative‐SFT, and rsFC for the dmPFC and pgACC. Greater negative‐SFT was associated with depression history and severity. Greater negative‐SFT predicted increased rsFC between dmPFC and pgACC seeds and dorsolateral prefrontal (dlPFC) and parietal regions; depression group was also associated with increased pgACC‐dlPFC connectivity. These findings are consistent with previous literature reporting elevated negative‐SFT thought in MDD. Our rs‐fMRI results provide novel support linking negative‐SFT with increased rsFC between self‐network and frontoparietal network regions across different levels of depression. Broadly, these findings highlight a dimension of social‐affective functioning that may underlie MDD and other psychiatric conditions.
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- Authors
- Philippi, C. L., Cornejo, M. D., Frost, C. P., Walsh, E. C., Hoks, R. M., Birn, R., & Abercrombie, H. C.
- Affiliations
- University of Missouri–St. Louis (US)
- University of Wisconsin–Madison (US)
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2018-02-09
- Volume
- 39
- Issue
- 5
- Pages
- 2246-2257
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC5895491
- OpenAlex
- W2793400821
- Cited by
- 60
- References
- 88
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 2
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRL - University of Missouri, St. Louis (University of Missouri–St. Louis) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH094478)
- National Center for Advancing Translational Sciences
- National Institutes of Health (KL2TR001109)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, resting-state functional connectivity, dorsomedial prefrontal cortex, pregenual anterior cingulate cortex, dorsolateral prefrontal cortex, parietal region, frontoparietal network, sentence completion task, depression severity, women
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Brain, Brain Mapping, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Psychiatric Status Rating Scales, Self-Assessment, Thinking, Young Adult
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