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Neurocognitive predictors of work outcome in recent-onset schizophrenia.
Open accessAbstract
While the role of neurocognitive impairment in predicting functional outcome in chronic schizophrenia is now widely accepted, the results that have examined this relationship in the early phase of psychosis are surprisingly rather mixed. The predictive role of cognitive impairment early in the illness is of particular interest because interventions during this initial period may help to prevent the development of chronic disability. In a University of California, Los Angeles (UCLA) longitudinal study, we assessed schizophrenia patients with a recent first episode of psychosis using a neurocognitive battery at an initial clinically stabilized outpatient point and then followed them during continuous treatment over the next 9 months. Three orthogonal cognitive factors were derived through principal components analysis: working memory, attention and early perceptual processing, and verbal memory and processing speed. All patients were provided a combination of maintenance antipsychotic medication, case management, group skills training, and family education in a UCLA research clinic. A modified version of the Social Adjustment Scale was used to assess work outcome. Multiple regression analyses indicate that the combination of the 3 neurocognitive factors predicts 52% of the variance in return to work or school by 9 months after outpatient clinical stabilization. These data strongly support the critical role of neurocognitive factors in recovery of work functioning after an onset of schizophrenia. Cognitive remediation and other interventions targeting these early cognitive deficits are of major importance to attempts to prevent chronic disability.
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“Cognitive dysfunction in human patients with schizophrenia is rapidly being considered amongst the most debilitating aspects of schizophrenia (Nuechterlein et al., 2011) and the severity of cognitive dysfunction is a key determinant of the functional outcome following treatment (Goldberg and Green, 2002).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Nuechterlein et al., 2011
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Metadata
- Authors
- Nuechterlein, K. H., Subotnik, K. L., Green, M. F., Ventura, J., Asarnow, R. F., Gitlin, M. J., Yee, C. M., Gretchen-Doorly, D., & Mintz, J.
- Affiliations
- University of California, Los Angeles (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Nuechterlein, K. H.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-22
- Volume
- 37
- Issue
- suppl 2
- Pages
- S33-S40
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3160123
- OpenAlex
- W2102694811
- Cited by
- 297
- References
- 47
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 19 · 2023: 5 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 24 · 2018: 28 · 2017: 22 · 2016: 29 · 2015: 30 · 2014: 29 · 2013: 24 · 2012: 9
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Janssen Scientific Affairs
- National Institute of Mental Health (MH037705, MH-066286, MH030911, R01MH037705, P50MH066286)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Education › Disability Education and Employment
- Keywords
- recent-onset schizophrenia, first-episode psychosis
- MeSH terms
- Adolescent, Adult, Cognition, Female, Follow-Up Studies, Humans, Male, Neuropsychological Tests, Regression Analysis, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Time Factors, Work, Outcome Assessment, Health Care, Young Adult
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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