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30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis

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Murray, Robin M, Bhavsar, Vishal, Tripoli, Giada, Howes, Oliver·2017·Schizophrenia Bulletin
DOI 10.1093/schbul/sbx121
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Abstract

At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on aberrant genes and early neural hazards, but then it grew to include ideas concerning aberrant synaptic pruning in adolescence. The hypothesis had its own stormy development and it endured some difficult teenage years when a resurgence of interest in neurodegeneration threatened its survival. In early adult life, it over-reached itself with some reductionists claiming that schizophrenia was simply a neurodevelopmental disease. However, by age 30, the hypothesis has matured sufficiently to incorporated childhood and adult adversity, urban living and migration, as well as heavy cannabis use, as important risk factors. Thus, it morphed into the developmental risk factor model of psychosis and integrated new evidence concerning dysregulated striatal dopamine as the final step on the pathway linking risk factors to psychotic symptoms.

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Cited by

Metadata

Authors
Murray, R. M., Bhavsar, V., Tripoli, G., & Howes, O.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
2017-09-14
Volume
43
Issue
6
Pages
1190-1196
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/sbx121
OpenAlex
W2754094519
Cited by
312
References
14
FWCI
17.14
Type
journal article
Language
en
Open access
bronze

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