The Relationship of Lymphocytes in Blood and in Lymph to Sleep/Wake States in Sheep
Abstract
Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave sleep and wake. Blood and lymph lymphocytes were phenotyped using monoclonal antibodies against CD4, CD8, gd T-cell receptors and a surface marker on ovine B cells. Lymph flow rates and efferent lymph cell output were measured. Lymph flow and prescapular efferent lymphocyte output were reduced during sleep compared to wakefulness (p<0.0005). There were no differences in lymphocyte subsets in the blood and in the lymph during sleep/wake brain states. These data indicate that migration of cells in the peripheral lymphatic system is altered during sleep compared to wakefulness.
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Two studies, one in sheep and the other in humans, provided more direct evidence that the efflux of lymphocytes from lymph nodes is reduced during sleep.
“Two studies, one in sheep (289) and the other in humans (351), provided more direct evidence that the efflux of lymphocytes from lymph nodes is reduced during sleep.”
From About Sleep's Role in Memory (2013) · cites this paper as [289]
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“In the periphery, recumbency and sleep-associated changes in the vasculature could likewise affect the draining of proteins from tissues and organs by the lymphatic system (143, 167, 168, 312).”
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- Authors
- Dickstein, J. B., Hay, J. B., Eng, F., & Moldofsky, H.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Harvey Moldofsky
- ORCID
- Harvey Moldofsky
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 23
- Issue
- 2
- Pages
- 185-90
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2474893875
- Cited by
- 24
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep-wake states, lymphocyte distribution, lymph flow, slow-wave sleep, sheep, CD4+ T cells, CD8+ T cells, γδ T cells, B cells, lymphocyte migration
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Surface, Cell Movement, Female, Lymph, Sheep, Sleep, REM, Wakefulness, Antigens, CD, Lymphocyte Subsets, Cytokines
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