Circadian impairment of distal skin temperature rhythm in patients with sleep-disordered breathing: the effect of CPAP
Abstract
Study objectives: Our aim was to evaluate the circadian rhythm of distal skin temperature (DST) in sleep-disordered breathing (SDB), its relation to excessive daytime sleepiness and the effect of continuous positive airway pressure (CPAP) on DST. Methods: Eighty SDB patients (53.1 ± 1.2 years old, 27.6% women) and 67 healthy participants (52.3 ± 1.6 years old, 26.9% women) wore a temperature data logger for 1 week. On the last day of that week, SDB patients underwent a polysomnography followed by a Maintenance of Wakefulness Test (MWT), Multiple Sleep Latency Test, and Sustained Attention to Response Task protocol to objectively quantify daytime sleepiness. A subset of 21 moderate to severe SDB patients were treated with CPAP during at least 3 months and revaluated with the same procedure. A nonparametric analysis was performed to characterize DST to assess differences between groups and associations among DST, polysomnography, and daytime sleepiness measures. Results: SDB patients showed an unstable, fragmented, flattened, phase-advanced, and less robust DST rhythm as compared to healthy participants. The more severe the SDB, the worse the DST pattern was, as indicated by the correlation coefficient. Sleepiness, according to MWT sleep latencies, was also associated with the higher fragmentation, lower amplitude, and less robustness of the DST rhythm. Treatment with CPAP improved DST pattern regularity and robustness. Conclusion: DST is altered in SDB, exhibiting a direct relationship to the severity of this condition, and improves with CPAP treatment. DST independently correlates with sleepiness, thus, its measurement may contribute to the understanding of the pathophysiology of sleepiness in these patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous human studies have demonstrated diminished temperature amplitude in other populations with disrupted sleep including shift work, metabolic syndrome, and sleep-disordered breathing.
“This is consistent with previous human studies demonstrating diminished temperature amplitude in other populations with disrupted sleep including shift work, metabolic syndrome, and sleep-disordered breathing [[62], [63], [64]].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [63]
Martinez-Nicolas et al. demonstrated improved circadian temperature amplitude in response to a CPAP intervention.
“In fact, similar to our study, Martinez-Nicolas et al. [63] demonstrated improved circadian temperature amplitude in response to a continuous positive airway pressure (CPAP) intervention, which suggests that physiological interventions can mitigate some circadian aspects of sleep disruption.”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [63]
Disruption of temperature rhythms has been strongly associated with sleep-disordered breathing.
“as well as sleep-disordered breathing16.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [16]
Cites
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
(2007) · Cited by 6,530 · see citing works
The International Classification of Sleep Disorders
Daroff, R. B. (1991) · Neurology · doi:10.1212/wnl.41.1.160 · Cited by 5,025 · see citing works
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-413_1 · Cited by 2,416 · see citing works
Robertson, I. H., Manly, T., Andrade, J., Baddeley, B., & Yiend, J. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00015-8 · Cited by 2,064 · see citing works
Kushida, C. A., Littner, M. R., Morgenthaler, T., Alessi, C. A., Bailey, D., Coleman, J., Friedman, L., Hirshkowitz, M., Kapen, S., Kramer, M., et al. (2005) · Sleep · doi:10.1093/sleep/28.4.499 · Cited by 2,054 · see citing works
Adherence to Continuous Positive Airway Pressure Therapy: The Challenge to Effective Treatment
Weaver, T. E., & Grunstein, R. R. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-119mg · Cited by 1,680 · see citing works
Guidelines for the Multiple Sleep Latency Test (MSLT): A Standard Measure of Sleepiness
Carskadon, M. A. (1986) · SLEEP · doi:10.1093/sleep/9.4.519 · Cited by 1,607 · see citing works
Littner, M. R., Kushida, C., Wise, M., G. Davila, D., Morgenthaler, T., Lee-Chiong, T., Hirshkowitz, M., Loube, D. L., Bailey, D., Berry, R. B., et al. (2005) · Sleep · doi:10.1093/sleep/28.1.113 · Cited by 1,142 · see citing works
Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works
Jelić, S., Padeletti, M., Kawut, S. M., Higgins, C., Canfield, S. M., Onat, D., Colombo, P. C., Basner, R. C., Factor, P. H., & LeJemtel, T. H. (2008) · Circulation · doi:10.1161/circulationaha.107.741512 · Cited by 621 · see citing works
Kushida, C. A., Nichols, D. A., Holmes, T. H., Quan, S. F., Walsh, J. K., Gottlieb, D. J., Simon, R., Guilleminault, C., White, D. P., Goodwin, J. L., et al. (2012) · SLEEP · doi:10.5665/sleep.2226 · Cited by 425 · see citing works
Skin-surface Temperature Gradients Correlate with Fingertip Blood Flow in Humans
Rubinstein, E. H., & Sessler, D. I. (1990) · Anesthesiology · doi:10.1097/00000542-199009000-00027 · Cited by 406 · see citing works
Warm feet promote the rapid onset of sleep
Kräuchi, K., Cajochen, C., Werth, E., & Wirz-Justice, A. (1999) · Nature · doi:10.1038/43366 · Cited by 398 · see citing works
Evaluation of wireless determination of skin temperature using iButtons
VANMARKENLICHTENBELT, W., DAANEN, H., WOUTERS, L., FRONCZEK, R., RAYMANN, R., SEVERENS, N., & VANSOMEREN, E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.04.026 · Cited by 392 · see citing works
Buijs, R. M., la Fleur, S. E., Wortel, J., van Heyningen, C., Zuiddam, L., Mettenleiter, T. C., Kalsbeek, A., Nagai, K., & Niijima, A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10765 · Cited by 356 · see citing works
Functional link between distal vasodilation and sleep-onset latency?
Kräuchi, K., Cajochen, C., Werth, E., & Wirz-Justice, A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.3.r741 · Cited by 356 · see citing works
VanSomeren, E. J. W. (2000) · Chronobiology International · doi:10.1081/cbi-100101050 · Cited by 329 · see citing works
Age-associated difference in circadian sleep–wake and rest–activity rhythms
Huang, Y.-L., Liu, R., Wang, Q., Someren, E. J. W. V., Xu, H., & Zhou, J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00733-3 · Cited by 291 · see citing works
Properties, Entrainment, and Physiological Functions of Mammalian Peripheral Oscillators
Stratmann, M., & Schibler, U. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293889 · Cited by 268 · see citing works
Diagnóstico y tratamiento del síndrome de apneas-hipopneas del sueño
Lloberes, P., Durán‐Cantolla, J., Martínez‐García, M. Á., Marín, J. M., Ferrer, A., Corral, J., Masa, J. F., Parra, O., Alonso-Álvarez, M. L., & Téran‐Santos, J. (2011) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2011.01.001 · Cited by 255 · see citing works
Circadian rhythm of wrist temperature in normal-living subjects
Sarabia, J. A., Rol, M. A., Mendiola, P., & Madrid, J. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.08.005 · Cited by 222 · see citing works
Self-citationChanges in circadian rhythms and sleep quality with aging: Mechanisms and interventions
Myers, B. L., & Badia, P. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00018-6 · Cited by 222 · see citing works
Skin deep: enhanced sleep depth by cutaneous temperature manipulation
Raymann, R. J. E. M., Swaab, D. F., & Van Someren, E. J. W. (2008) · Brain · doi:10.1093/brain/awm315 · Cited by 218 · see citing works
Circadian Clues to Sleep Onset Mechanisms
Kräuchi, K. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00315-3 · Cited by 213 · see citing works
The Effect of Cool Water Ingestion on Gastrointestinal Pill Temperature
Wilkinson, D. M., Carter, J. M., Richmond, V. L., Blacker, S. D., & Rayson, M. P. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815cc43e · Cited by 197 · see citing works
Someren, E. J. W. V. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00030-2 · Cited by 195 · see citing works
Ortiz‐Tudela, E., Martínez-Nicolás, A., Campos, M., Rol, M. A., & Madrid, J. A. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000996 · Cited by 189 · see citing works
Self-citationSleep-Wake as a Biological Rhythm
Lavie, P. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.277 · Cited by 186 · see citing works
Fleetham, J. A., Ayas, N., Bradley, D., Ferguson, K., Fitzpatrick, M., George, C., Hanly, P. J., Hill, F., Kimoff, J. R., Kryger, M. H., et al. (2006) · Canadian Respiratory Journal · doi:10.1155/2006/627096 · Cited by 166 · see citing works
The interrelationship between sleep regulation and thermoregulation
Krauchi, K. (2010) · Frontiers in bioscience · doi:10.2741/3636 · Cited by 156 · see citing works
Bonmati-Carrion, M. A., Middleton, B., Revell, V., Skene, D. J., Rol, M. A., & Madrid, J. A. (2014) · Chronobiology International · doi:10.3109/07420528.2013.820740 · Cited by 116 · see citing works
Self-citationPeripheral Chemoreception and Arterial Pressure Responses to Intermittent Hypoxia
Prabhakar, N. R., Peng, Y., Kumar, G. K., & Nanduri, J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140039 · Cited by 109 · see citing works
Fragmentation and Stability of Circadian Activity Rhythms Predict Mortality
Zuurbier, L. A., Luik, A. I., Albert Hofman, D., Franco, O. H., Someren, E. J. W. V., & Tiemeier, H. W. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu245 · Cited by 109 · see citing works
Swanson, C. M., Shea, S. A., Stone, K. L., Cauley, J. A., Rosen, C. J., Redline, S. S., Karsenty, G., & ORWOLL, E. S. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2446 · Cited by 104 · see citing works
Irregular 24-hour activity rhythms and the metabolic syndrome in older adults
Sohail, S., Yu, L., Bennett, D. A., Buchman, A. S., & Lim, A. S. P. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1041597 · Cited by 102 · see citing works
Thomasouli, M.-A., Brady, E. M., Davies, M. J., Hall, A. P., Khunti, K. K., Morris, D. H., & Gray, L. J. (2013) · Sleep And Breathing · doi:10.1007/s11325-013-0806-7 · Cited by 101 · see citing works
Diagnosis and treatment of sleep apnea-hypopnea syndrome
Lloberes, P., Durán‐Cantolla, J., Martínez‐García, M. Á., Marín, J. M., Ferrer, A., Corral, J., Masa, J. F., Parra, O., Alonso-Álvarez, M. L., & Téran‐Santos, J. (2011) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(11)70034-9 · Cited by 99 · see citing works
Corbalán-Tutau, M. D., Madrid, J. A., Ordovás, J. M., Smith, C. E., Nicolás, F., & Garaulet, M. (2011) · Chronobiology International · doi:10.3109/07420528.2011.574766 · Cited by 94 · see citing works
Self-citationMartínez-Nicolás, A., Meyer, M., Hunkler, S., Madrid, J. A., Rol, M. A., Meyer, A. H., Schötzau, A., Orgül, S., & Kräuchi, K. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.014 · Cited by 93 · see citing works
Self-citationAltered Skin-Temperature Regulation in Narcolepsy Relates to Sleep Propensity
Fronczek, R., Overeem, S., Lammers, G. J., van Dijk, J. G., & van Someren, E. J. W. (2006) · Sleep · doi:10.1093/sleep/29.11.1444 · Cited by 92 · see citing works
Waking up properly: Is there a role of thermoregulation in sleep inertia?
Kräuchi, K., Cajochen, C., & Wirz‐Justice, A. (2004) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2004.00398.x · Cited by 91 · see citing works
Silva, G. E., An, M., Goodwin, J. L., Shahar, E., Redline, S. S., Resnick, H. E., Baldwin, C. M., & Quan, S. F. (2009) · SLEEP · doi:10.1093/sleep/32.8.1049 · Cited by 90 · see citing works
Crosstalk Between Environmental Light and Internal Time in Humans
Martínez-Nicolás, A., Ortiz‐Tudela, E., Madrid, J. A., & Rol, M. A. (2011) · Chronobiology International · doi:10.3109/07420528.2011.593278 · Cited by 85 · see citing works
Self-citationKräuchi, K., Knoblauch, V., Wirz-Justice, A., & Cajochen, C. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00381.2005 · Cited by 83 · see citing works
Phillips, C. L., McEwen, B. J., Morel-Kopp, M.-C., Yee, B. J., Sullivan, D. R., Ward, C. M., Tofler, G. H., & Grunstein, R. R. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-200874 · Cited by 82 · see citing works
van Schie, M. K. M., Thijs, R. D., Fronczek, R., Middelkoop, H. A. M., Lammers, G. J., & van Dijk, J. G. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2011.00979.x · Cited by 80 · see citing works
Lubrano, C., Saponara, M., Bárbaro, G., Specchia, P., Addessi, E., Costantini, D., Tenuta, M., Lorenzo, G. D., Genovesi, G., Donini, L. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047059 · Cited by 79 · see citing works
Fronczek, R., Raymann, R. J. E. M., Romeijn, N., Overeem, S., Fischer, M., Dijk, J. G. V., Jan Lammers, G., & Van Someren, E. J. W. (2008) · Sleep · doi:10.1093/sleep/31.2.233 · Cited by 76 · see citing works
Fronczek, R., Middelkoop, H. A. M., van Dijk, J. G., & Lammers, G. J. (2006) · SLEEP · doi:10.1093/sleep/29.2.187 · Cited by 71 · see citing works
Raymann, R. J. E. M., & Van Someren, E. J. W. (2007) · Sleep · doi:10.1093/sleep/30.1.96 · Cited by 70 · see citing works
Borel, A., Leblanc, X., Alméras, N., Tremblay, A., Bergeron, J., Poirier, P., Després, J., & Sériès, F. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-201001 · Cited by 69 · see citing works
Uncovering Different Masking Factors on Wrist Skin Temperature Rhythm in Free-Living Subjects
Martínez-Nicolás, A., Ortiz‐Tudela, E., Rol, M. A., & Madrid, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061142 · Cited by 67 · see citing works
Self-citationOrtiz‐Tudela, E., Martínez-Nicolás, A., Albares, J. B., Segarra, F., Campos, M., Estivill, E., Rol, M. A., & Madrid, J. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.12.009 · Cited by 67 · see citing works
Self-citationDay–night contrast as source of health for the human circadian system
Martínez-Nicolás, A., Madrid, J. A., & Rol, M. A. (2013) · Chronobiology International · doi:10.3109/07420528.2013.861845 · Cited by 65 · see citing works
Self-citationThe Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea
Butler, M. P., Smales, C., Wu, H., Hussain, M. V., Mohamed, Y. A., Morimoto, M., & Shea, S. A. (2015) · SLEEP · doi:10.5665/sleep.5166 · Cited by 65 · see citing works
Thermophysiologic Aspects of the Three-Process-Model of Sleepiness Regulation
Kräuchi, K., Cajochen, C., & Wirz‐Justice, A. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.009 · Cited by 58 · see citing works
Rapoport, D. M. (2015) · CHEST Journal · doi:10.1378/chest.15-1319 · Cited by 58 · see citing works
Manipulation of skin temperature improves nocturnal sleep in narcolepsy
Fronczek, R., Raymann, R. J. E. M., Overeem, S., Romeijn, N., van Dijk, J. G., Lammers, G. J., & Van Someren, E. J. W. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.143610 · Cited by 51 · see citing works
Kräuchi, K., Gasio, P. F., Vollenweider, S., von Arb, M., Dubler, B., Orgül, S., Flammer, J., & Stutz, E. Z. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00678.x · Cited by 49 · see citing works
Blazquez, A., Martínez-Nicolás, A., Salazar, F. J., Rol, M. A., & Madrid, J. A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.679328 · Cited by 47 · see citing works
Self-citationKräuchi, K., Konieczka, K., Roescheisen-Weich, C., Gompper, B., Hauenstein, D., Schoetzau, A., Fraenkl, S., & Flammer, J. (2014) · Chronobiology International · doi:10.3109/07420528.2013.829482 · Cited by 46 · see citing works
Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea
Idiáquez, J., Santos, I., Santín, J., Río, R. D., & Iturriaga, R. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.05.030 · Cited by 41 · see citing works
Romeijn, N., Verweij, I. M., Koeleman, A., Mooij, A., Steimke, R., Virkkala, J., van der Werf, Y., & Van Someren, E. J. W. (2012) · Sleep · doi:10.5665/sleep.2242 · Cited by 41 · see citing works
Bagai, K., Muldowney, J. A. S., Song, Y., Wang, L., Bagai, J., Artibee, K. J., Vaughan, D. E., & Malow, B. A. (2014) · SLEEP · doi:10.5665/sleep.3414 · Cited by 39 · see citing works
Tamisier, R., Tan, C. O., Pépin, J., Levy, P. A., & Taylor, J. A. (2015) · SLEEP · doi:10.5665/sleep.5252 · Cited by 38 · see citing works
Maser, R. E., Lenhard, M. J., Rizzo, A. A., & Vasile, A. A. (2007) · CHEST Journal · doi:10.1378/chest.07-1580 · Cited by 38 · see citing works
Kräuchi, K., Gompper, B., Hauenstein, D., Flammer, J., Pflueger, M. O., Studerus, E., Schötzau, A., & Orgül, S. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719961 · Cited by 38 · see citing works
Ontogeny and aging of the distal skin temperature rhythm in humans
Batinga, H., Martínez-Nicolás, A., Moreno, M. Z., Sánchez‐Solís, M., Larqué, E., Mondéjar, M. T., Moreno‐Casbas, T., García‐García, F. J., Campos, M., Rol, M. A., et al. (2015) · AGE · doi:10.1007/s11357-015-9768-y · Cited by 36 · see citing works
Self-citationLemmer, B., Scholtze, J., & Schmitt, J. (2015) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000173 · Cited by 29 · see citing works
Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin
Lucas-Sánchez, A., Pagán, P., Martínez-Nicolás, A., Madrid, J. A., Mendiola, P., & Costa, J. D. A. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.026 · Cited by 27 · see citing works
Self-citationGuaita, M., Salamero, M., Vilaseca, I., Iranzo, Á., Montserrat, J. M., Gaig, C., Embid, C., Romero, M., Serradell, M., León, C., et al. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5188 · Cited by 23 · see citing works
Self-citationPeripheral Chemoreception and Arterial Pressure Responses to Intermittent Hypoxia
Prabhakar, N. R., Peng, Y., Kumar, G. K., & Nanduri, J. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00620.x · Cited by 18 · see citing works
Effect of Short Term C PAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome
Kanimozhi, S. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/13301.5859 · Cited by 15 · see citing works
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients
Blomster, H., Tuomilehto, H., Laitinen, T. P., Laitinen, T. M., Randell, J. T., Kokkarinen, J. I., Gylling, H., Sahlman, J., Seppä, J., Hartikainen, J. E. K., et al. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s82443 · Cited by 12 · see citing works
Lucas-Sánchez, A., Martínez-Nicolás, A., Madrid, J. A., Pagán, P., Mendiola, P., & Costa, J. D. A. (2014) · Chronobiology International · doi:10.3109/07420528.2014.984040 · Cited by 7 · see citing works
Self-citationCircadian Reactions to nCPAP Treatment
Moog, R., Fietze, I., Penzel, T., Peter, J. H., & Vogel, M. (1998) · Chronobiology International · doi:10.3109/07420529808998688 · Cited by 7 · see citing works
Why excessive sleepiness may persist in OSA patients receiving adequate CPAP treatment
Castiglioni, P., Lombardi, C., Cortelli, P., & Parati, G. (2011) · European Respiratory Journal · doi:10.1183/09031936.00147111 · Cited by 6 · see citing works
Circadian impairment of the wrist temperature rhythm in patients with sleep disordered breathing
Martínez-Nicolás, A., Guaita, M., Santamaría, J., Montserrat, J. M., Madrid, J. A., & Rol, A. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.11.451 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ryan, S., Cummins, E. P., Farré, R., Gileles‐Hillel, A., Jun, J. C., Oster, H., Pépin, J., Ray, D. W., Reutrakul, S., Sánchez‐de‐la‐Torre, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02295-2019 · Cited by 70 · see citing works
Saner, N. J., Lee, M. J.-C., Kuang, J., Pitchford, N. W., Roach, G. D., Garnham, A., Genders, A. J., Stokes, T., Schroder, E. A., Huo, Z., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101110 · Cited by 68 · see citing works
Multidimensional Circadian Monitoring by Wearable Biosensors in Parkinson’s Disease
Madrid-Navarro, C. J., Sevilla, F. E., Mínguez‐Castellanos, A., Campos, M., Abellán, F. R., Madrid, J. A., & Rol, M. A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00157 · Cited by 59 · see citing works
Self-citationCambras, T., Castro‐Marrero, J., Zaragozá, M. C., Dı́ez-Noguera, A., & Alegre, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198106 · Cited by 57 · see citing works
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Brooks, T. G., Lahens, N. F., Grant, G. R., Sheline, Y. I., FitzGerald, G. A., & Skarke, C. (2023) · Nature Communications · doi:10.1038/s41467-023-40977-5 · Cited by 57 · see citing works
Madrid-Navarro, C. J., Puertas, F. J., Sevilla, F. E., Campos, M., Abellán, F. R., Rol, M. A., & Madrid, J. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00356 · Cited by 54 · see citing works
Self-citationCircadian monitoring as an aging predictor
Martínez-Nicolás, A., Madrid, J. A., García‐García, F. J., Campos, M., Moreno‐Casbas, T., Pagán, P., Lucas-Sánchez, A., & Rol, M. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-33195-3 · Cited by 52 · see citing works
Self-citationAssessing Chronotypes by Ambulatory Circadian Monitoring
Martínez-Nicolás, A., Martínez-Madrid, M. J., Pagán, P., Bonmatí‐Carrión, M., Madrid, J. A., & Rol, M. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01396 · Cited by 53 · see citing works
Self-citationHow Does Fitbit Measure Brainwaves
Liang, Z., & Ploderer, B. (2020) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3380994 · Cited by 36 · see citing works
de Assis, L. V. M., Moraes, M. N., & Castrucci, A. M. D. L. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03183-5 · Cited by 33 · see citing works
Circadian Biology in Obstructive Sleep Apnea
Koritala, B. S. C., Conroy, Z., & Smith, D. F. (2021) · Diagnostics · doi:10.3390/diagnostics11061082 · Cited by 31 · see citing works
Koritala, B. S. C., Lee, Y. Y., Gaspar, L. S., Bhadri, S. S., Su, W., Wu, G., Francey, L. J., Ruben, M. D., Gong, M. C., Hogenesch, J. B., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002139 · Cited by 26 · see citing works
Serrano-Serrano, A. B., Marquez-Arrico, J. E., Navarro, J. F., Martínez-Nicolás, A., & Adán, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194388 · Cited by 23 · see citing works
Geng, Y., Smolensky, M. H., Sum‐Ping, O., Hermida, R. C., & Castriotta, R. J. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2080557 · Cited by 21 · see citing works
Adán, A., Marquez-Arrico, J. E., Río-Martínez, L., Navarro, J. F., & Martínez-Nicolás, A. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01560-7 · Cited by 23 · see citing works
Skin temperature response to a liquid meal intake is different in men than in women
Martínez‐Téllez, B., Ortiz-Alvarez, L., Sánchez‐Delgado, G., Xu, H., Acosta, F. M., Merchán-Ramírez, E., Muñoz-Hernández, V., Martinez-Avila, W. D., Contreras-Gomez, M. A., Gil, Á., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.05.026 · Cited by 20 · see citing works
Tai, Y., Obayashi, K., Yamagami, Y., & Saeki, K. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10590 · Cited by 18 · see citing works
Capella, M. D. M., Martinez-Nicolas, A., & Adan, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00373 · Cited by 17 · see citing works
Haghayegh, S., Smolensky, M. H., Khoshnevis, S., Hermida, R. C., Castriotta, R. J., & Diller, K. R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210008 · Cited by 16 · see citing works
Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock
Pagán, P., Torrente, M., Campos, M., Provencio, M., Madrid, J. A., Franco, F., Morilla, B. R., Cantos, B., Sousa, P., Martínez-Madrid, M. J., et al. (2022) · Current Oncology Reports · doi:10.1007/s11912-021-01158-z · Cited by 13 · see citing works
Self-citationTemperatus® software: A new tool to efficiently manage the massive information generated by iButtons
Martínez‐Téllez, B., Quesada-Aranda, A., Sánchez‐Delgado, G., Fernández-Luna, J. M., & Ruiz, J. R. (2019) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2019.03.007 · Cited by 13 · see citing works
Acosta, F. M., Martínez‐Téllez, B., Blondin, D. P., Haman, F., Rensen, P. C. N., Elvira, J. M. L., Martínez-Nicolás, A., & Ruiz, J. R. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730419865400 · Cited by 13 · see citing works
Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
Martínez-Nicolás, A., Guaita, M., Santamaría, J., Montserrat, J. M., Madrid, J. A., & Rol, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-94315-0 · Cited by 12 · see citing works
Self-citationBarnadas-Solé, C., Zerón-Rugerio, M. F., Corvinos, J. F., Dı́ez-Noguera, A., Cambras, T., & Izquierdo-Pulido, M. (2021) · Chronobiology International · doi:10.1080/07420528.2020.1866003 · Cited by 8 · see citing works
Dittmar, M., Stark, T., & Wedell, S. (2024) · Geriatrics · doi:10.3390/geriatrics9040102 · Cited by 7 · see citing works
Zerón-Rugerio, M. F., Dı́ez-Noguera, A., Izquierdo-Pulido, M., & Cambras, T. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1785486 · Cited by 7 · see citing works
Circadian Biology in Obstructive Sleep Apnea-Associated Cardiovascular Disease
Gaspar, L. S., Pyakurel, S., Xu, N., D’Souza, S. P., & Koritala, B. S. C. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.03.008 · Cited by 5 · see citing works
Integral Analysis of Circadian Rhythms
Vicente-Martínez, J., González-Romero, P., Pagán, P., Martínez-Nicolás, A., Madrid, J. A., Rol, M. A., & Bonmatí‐Carrión, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-32729-2_9 · Cited by 3 · see citing works
Self-citationAltered Core Temperature and Salivary Melatonin in Athletes with a Cervical Spinal Cord Injury
Murphy, C. J., Hartescu, I., Leicht, C. A., & Goosey-Tolfrey, V. L. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1925-7531 · Cited by 3 · see citing works
Martínez‐Téllez, B., Adelantado‐Renau, M., Acosta, F. M., Sánchez‐Delgado, G., Martínez-Nicolás, A., Boon, M. R., Elvira, J. M. L., Martínez‐Vizcaíno, V., & Ruiz, J. R. (2019) · Obesity · doi:10.1002/oby.22461 · Cited by 3 · see citing works
Verhoef, V. T. R., Smolders, K. C. H. J., Peeters, G., Overeem, S., & de Kort, Y. A. W. (2025) · Clocks & Sleep · doi:10.3390/clockssleep7030051 · Cited by 2 · see citing works
Martínez-Alarcón, L., Martínez-Nicolás, A., Jover-Aguilar, M., López‐López, V., Alconchel, F., Ríos, A., Madrid, J. A., Rol, M. A., Ramírez, P., & Ramis, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154529 · Cited by 2 · see citing works
Self-citationHaghayegh, S., Smolensky, M. H., Khoshnevis, S., Hermida, R. C., Castriotta, R. J., & Diller, K. R. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00193.x · Cited by 2 · see citing works
Analysis and management of sleep data
Janott, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818946-7.00008-1 · Cited by 2 · see citing works
Garcia‐Molina, G., Winger, T., Rao, M. R., McGhee, L., Makaram, N., Chernega, P., Shcherbakov, Y., Chellamuthu, V., Veneros, E., Mills, R., et al. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03437-6 · Cited by 1 · see citing works
TAMURA, H., Matsuura, N., KITAMURA, K., & Yamanaka, Y. (2021) · Japanese Journal of Physiological Psychology and Psychophysiology · doi:10.5674/jjppp.2110si · Cited by 1 · see citing works
Uncorrelated Age-Related Changes in Visuo-Spatial Working Memory Binding and Thermoregulation
Dourte, M., Hammad, G. H., Schmidt, C., & Peigneux, P. (2025) · Clocks & Sleep · doi:10.3390/clockssleep7020017
Dourte, M., Hammad, G. H., Haan, S. D., Deantoni, M., Reyt, M., Baillet, M., Lesoinne, A., Muto, V., Collette, F., Vandewalle, G., et al. (2026) · Temperature · doi:10.1080/23328940.2026.2623852
Age-related patterns in distal skin temperature during naps
Soltani, S., Hartogensis, W., Kasl, P., Dasgupta, S., Dilchert, S., Hecht, F. M., Smarr, B. L., & Mason, A. E. (2026) · SLEEP · doi:10.1093/sleep/zsag077
Sleep Disordered Breathing Severity Alters Overnight Temperature Changes in Children
Plunkett, G., Shetty, M., Vaz‐Serra, M., Delanaud, S., Nisbet, L. C., Davey, M. J., Nixon, G. M., Horne, R. S. C., & Bach, V. (2026) · Journal of Sleep Research · doi:10.1111/jsr.70340
Martínez-Martínez, D., González-Romero, P., Rodríguez-Morilla, B., Bonmatí‐Carrión, M., Rol, M. A., & Pagán, P. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1787735
Self-citationVerhoef, V. T. R., Smolders, K. C. H. J., Peeters, G., Overeem, S., & de Kort, Y. A. W. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2696432
- Authors
- Martinez-Nicolas, A., Guaita, M., Santamaría, J., Montserrat, J. M., Rol, M. Á., & Madrid, J. A.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-22
- Volume
- 40
- Issue
- 6
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2607104068
- Cited by
- 42
- References
- 79
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep-disordered breathing, obstructive sleep apnea, circadian rhythm, continuous positive airway pressure, excessive daytime sleepiness, sleep fragmentation, CPAP treatment response, temperature loggers
- MeSH terms
- Circadian Rhythm, Female, Humans, Male, Middle Aged, Skin Temperature, Sleep Apnea Syndromes, Sleep Stages, Wakefulness, Case-Control Studies, Polysomnography, Continuous Positive Airway Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
