Across-night dynamics in traveling sleep slow waves throughout childhood
Open accessAbstract
Study Objectives: Sleep slow waves behave like traveling waves and are thus a marker for brain connectivity. Across a night of sleep in adults, wave propagation is scaled down, becoming more local. Yet, it is unknown whether slow wave propagation undergoes similar across-night dynamics in childhood-a period of extensive cortical rewiring. Methods: High-density electroencephalography (EEG; 128 channels) was recorded during sleep in three groups of healthy children: 2.0-4.9 years (n = 11), 5.0-8.9 years (n = 9) and 9.0-16.9 years (n = 9). Slow wave propagation speed, distance, and cortical involvement were quantified. To characterize across-night dynamics, the 20% most pronounced (highest amplitude) slow waves were subdivided into five time-based quintiles. Results: We found indications that slow wave propagation distance decreased across a night of sleep. We observed an interesting interaction of across-night slow wave propagation dynamics with age (p < 0.05). When comparing the first and last quintiles, there was a trend level difference between age groups: 2- to 4.9-year-old children showed an 11.9% across-night decrease in slow wave propagation distance, which was not observed in the older two age groups. Regardless of age, cortical involvement decreased by 10.4%-23.7% across a night of sleep. No across-night changes were observed in slow wave speed. Conclusions: Findings provide evidence that signatures of brain connectivity undergo across-night dynamics specific to maturational periods. These results suggest that across-night dynamics in slow wave propagation distance reflect heightened plasticity in underlying cerebral networks specific to developmental periods.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Slow oscillatory activity shows an inverted U-shaped trajectory peaking during early adolescence.
“Subsequently, slow oscillatory activity shows an inverted U-shaped trajectory peaking during early adolescence”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [253]
The Introduction (p. 3) says slow wave activity reaches its maximum during childhood and declines throughout adolescence, contrary to a peak in early adolescence. The Age groups section (p. 5) places the maximum in the 5–8.9-year age group. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe inverted U-shaped trajectory of slow oscillatory activity presumably reflects parallel changes in cortical synaptic connectivity and white matter microstructure.
“which presumably reflects parallel changes in cortical synaptic connectivity and white matter microstructure.253”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [253]
The Introduction (p. 3) says slow-wave activity peaks in childhood and declines through adolescence, and links slow waves to synaptic connectivity. It also links slow-wave propagation parameters to white matter microstructure, but does not say that the inverted U-shaped trajectory of slow-wave activity reflects parallel changes in white matter microstructure. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
(2007) · Cited by 6,530 · see citing works
Brain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552 · see citing works
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356 · see citing works
Mapping cortical change across the human life span
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
MuMIn : multi-model inference, R package version 0.12.0
Bartoń, K. A. (2009) · Medical Entomology and Zoology · Cited by 1,686 · see citing works
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395 · see citing works
Sexual dimorphism of brain developmental trajectories during childhood and adolescence
Lenroot, R. K., Gogtay, N., Greenstein, D. K., Wells, E. M., Wallace, G. L., Clasen, L. S., Blumenthal, J. D., Lerch, J., Zijdenbos, A. P., Evans, A. C., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.053 · Cited by 1,309 · see citing works
The sleep slow oscillation as a traveling wave
Massimini, M., Huber, R., Ferrarelli, F., Hill, S., & Tononi, G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1318-04.2004 · Cited by 1,221 · see citing works
Self-citationA meta-analysis of sex differences in human brain structure
Ruigrok, A. N. V., Salimi-Khorshidi, G., Lai, M.-C., Baron-Cohen, S., Lombardo, M. V., Tait, R. J., & Suckling, J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.004 · Cited by 1,192 · see citing works
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924 · see citing works
The dual systems model: Review, reappraisal, and reaffirmation
Shulman, E. P., Smith, A. R., Silva, K., Icenogle, G., Duell, N., Chein, J., & Steinberg, L. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.010 · Cited by 867 · see citing works
Maturation of white matter in the human brain: A review of magnetic resonance studies.
Paus, T., Collins, D. L., Evans, A. C., Leonard, G., Pike, B., & Zijdenbos, A. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00434-2 · Cited by 863 · see citing works
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740 · see citing works
Steriade, M., Contreras, D., Dossi, R. C., & Núñez, Á. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03284.1993 · Cited by 723 · see citing works
Adolescent changes in the homeostatic and circadian regulation of sleep
Hagenauer, M. H., Perryman, J. I., Lee, T. M., & Carskadon, M. A. (2009) · Developmental Neuroscience · doi:10.1159/000216538 · Cited by 593 · see citing works
A Critical Period of Brain Development: Studies of Cerebral Glucose Utilization with PET
Chugani, H. T. (1998) · Preventive Medicine · doi:10.1006/pmed.1998.0274 · Cited by 590 · see citing works
Steriade, M., Contreras, D., & Nuiiez, A. (1993) · Cited by 584 · see citing works
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574 · see citing works
REM sleep selectively prunes and maintains new synapses in development and learning
Li, W., Ma, L., Yang, G., & Gan, W.-B. (2017) · Nature Neuroscience · doi:10.1038/nn.4479 · Cited by 543 · see citing works
Source modeling sleep slow waves
Murphy, M., Riedner, B. A., Huber, R., Massimini, M., Ferrarelli, F., & Tononi, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807933106 · Cited by 454 · see citing works
Self-citationChanges in Sleep as a Function of Adolescent Development
Colrain, I. M., & Baker, F. C. (2011) · Neuropsychology Review · doi:10.1007/s11065-010-9155-5 · Cited by 452 · see citing works
Social re-orientation and brain development: An expanded and updated view
Nelson, E. E., Jarcho, J. M., & Guyer, A. E. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.008 · Cited by 447 · see citing works
Kurth, S., Ringli, M., Geiger, A., LeBourgeois, M., Jenni, O. G., & Huber, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2532-10.2010 · Cited by 373 · see citing works
Self-citationProcesses of change in brain and cognitive development
Johnson, M. H., & Munakata, Y. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.01.009 · Cited by 337 · see citing works
Sleep EEG changes during adolescence: An index of a fundamental brain reorganization
Feinberg, I., & Campbell, I. G. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.09.008 · Cited by 280 · see citing works
Exposure to pulsed high-frequency electromagnetic field during waking affects human sleep EEG
Huber, R., Graf, T., Côté, K. A., Wittmann, L., Gallmann, E., Matter, D., Schuderer, J., Kuster, N., Borbély, A. A., & Achermann, P. (2000) · Neuroreport · doi:10.1097/00001756-200010200-00012 · Cited by 268 · see citing works
Self-citationVyazovskiy, V. V., Riedner, B. A., Cirelli, C., & Tononi, G. (2007) · SLEEP · doi:10.1093/sleep/30.12.1631 · Cited by 225 · see citing works
Scholle, S., Beyer, U., Bernhard, M., Eichholz, S., Erler, T., Graneß, P., Goldmann-Schnalke, B., Heisch, K., Kirchhoff, F., Klementz, K., et al. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.11.011 · Cited by 174 · see citing works
Characterizing longitudinal white matter development during early childhood
Dean, D. C., O’Muircheartaigh, J., Dirks, H., Waskiewicz, N., Walker, L., Doernberg, E., Piryatinsky, I., & Deoni, S. C. L. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0763-3 · Cited by 174 · see citing works
Self-citationCharacteristics of sleep slow waves in children and adolescents
Kurth, S., Jenni, O. G., Riedner, B. A., Tononi, G., Carskadon, M. A., & Huber, R. (2010) · Sleep · doi:10.1093/sleep/33.4.475 · Cited by 156 · see citing works
Self-citationDevelopmental changes in the human sleep EEG during early adolescence.
Tarokh, L., & Carskadon, M. (2010) · Sleep · doi:10.1093/sleep/33.6.801 · Cited by 147 · see citing works
Developmental aspects of sleep slow waves
Ringli, M., & Huber, R. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53839-0.00005-3 · Cited by 134 · see citing works
Self-citationKurth, S., Ringli, M., LeBourgeois, M. K., Geiger, A., Buchmann, A., Jenni, O. G., & Huber, R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.053 · Cited by 129 · see citing works
Self-citationSleep slow-wave activity reveals developmental changes in experience-dependent plasticity
Wilhelm, I., Kurth, S., Ringli, M., Mouthon, A.-L., Buchmann, A., Geiger, A., Jenni, O. G., & Huber, R. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0962-14.2014 · Cited by 108 · see citing works
Self-citationLongitudinal sleep EEG trajectories indicate complex patterns of adolescent brain maturation
Feinberg, I., & Campbell, I. G. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00422.2012 · Cited by 105 · see citing works
Sleep-Dependent Plasticity Requires Cortical Activity
Jha, S. K., Jones, B. E., Coleman, T., Steinmetz, N., Law, C.-T., Griffin, G., Hawk, J., Dabbish, N., Kalatsky, V. A., & Frank, M. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2722-05.2005 · Cited by 96 · see citing works
Temporal evolution of coherence and power in the human sleep electroencephalogram
Achermann, P., & BorbÉly, A. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.7.s1.6.x · Cited by 89 · see citing works
Campbell, I. G., Darchia, N., Higgins, L. M., Dykan, I. V., Davis, N. M., de Bie, E., & Feinberg, I. (2011) · SLEEP · doi:10.1093/sleep/34.1.83 · Cited by 87 · see citing works
Traveling Slow Oscillations During Sleep: A Marker of Brain Connectivity in Childhood
Kurth, S., Riedner, B. A., Dean, D., O’Muircheartaigh, J., Huber, R., Jenni, O. G., Deoni, S., & LeBourgeois, M. K. (2017) · SLEEP · doi:10.1093/sleep/zsx121 · Cited by 77 · see citing works
Self-citationDevelopmental changes in brain connectivity assessed using the sleep EEG
Tarokh, L., Carskadon, M. A., & Achermann, P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.071 · Cited by 73 · see citing works
Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role?
Kurth, S., Achermann, P., Rusterholz, T., & LeBourgeois, M. K. (2013) · Brain Sciences · doi:10.3390/brainsci3041445 · Cited by 73 · see citing works
Self-citationTopographic Differences in the Adolescent Maturation of the Slow Wave EEG during NREM Sleep
Feinberg, I., de Bie, E., Davis, N. M., & Campbell, I. G. (2011) · SLEEP · doi:10.1093/sleep/34.3.325 · Cited by 61 · see citing works
Overnight Changes in the Slope of Sleep Slow Waves during Infancy
Fattinger, S., Jenni, O. G., Schmitt, B., Achermann, P., & Huber, R. (2014) · SLEEP · doi:10.5665/sleep.3390 · Cited by 49 · see citing works
Self-citationSynaptic refinement during development and its effect on slow-wave activity: a computational study
Hoel, E. P., Albantakis, L., Cirelli, C., & Tononi, G. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00812.2015 · Cited by 30 · see citing works
Latent Growth Curve and Repeated Measures ANOVA Contrasts: What the Models are Telling You
Rovine, M. J., & McDermott, P. A. (2017) · Multivariate Behavioral Research · doi:10.1080/00273171.2017.1387511 · Cited by 22 · see citing works
Diurnal changes in electrocorticogram sleep slow‐wave activity during development in rats
Olini, N., & Huber, R. (2014) · Journal of Sleep Research · doi:10.1111/jsr.12124 · Cited by 12 · see citing works
Self-citationSleep Slow Oscillations and Cortical Maturation
Kurth, S., & Huber, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384995-3.00010-1 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [20]20. Kurth S, et al . Characteristics of sleep slow waves in children and adolescents. Sleep . 2010; 33 (4):475-480.
Cited by
Sorted by citations
Sleep—A brain-state serving systems memory consolidation
Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.005 · Cited by 343 · see citing works
Spatio-temporal properties of sleep slow waves and implications for development
Timofeev, I., Schoch, S. F., LeBourgeois, M. K., Huber, R., Riedner, B. A., & Kurth, S. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.007 · Cited by 83 · see citing works
Self-citation
- Authors
- Schoch, S. F., Riedner, B. A., Deoni, S. C., Huber, R., LeBourgeois, M. K., & Kurth, S.
- Affiliations
- University Hospital Zurich (CH)
- University of Wisconsin–Madison (US)
- Women & Infants Hospital of Rhode Island (US)
- University Children's Hospital Zurich (CH)
- University of Colorado Boulder (US)
- Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-29
- Volume
- 41
- Issue
- 11
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC6231526
- OpenAlex
- W2890457875
- Cited by
- 31
- References
- 49
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Clinical Research Priority Program Sleep and Health
- Swiss National Science Foundation (PBZHP3-138801, PBZHP3-147180, P0ZHP1-178697)
- National Institutes of Health (R01-MH086566)
- Jacob’s Foundation
- Center for Innovation and Creativity
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- sleep slow waves, slow wave propagation, traveling waves, children's sleep, brain connectivity, cortical involvement, brain maturation, neuroplasticity
- MeSH terms
- Sleep, Slow-Wave, Adolescent, Adult, Brain, Child, Child, Preschool, Cross-Sectional Studies, Electroencephalography, Female, Humans, Male, Sleep, Brain Waves
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
