Altered sleep architecture, rapid eye movement sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion
Open accessAbstract
Sleep abnormalities are common among children with neurodevelopmental disorders. The human chr16p11.2 microdeletion is associated with a range of neurological and neurobehavioral abnormalities. Previous studies of a mouse model of human chr16p11.2 microdeletion (chr16p11.2df/+) have demonstrated pathophysiological changes at the synapses in the hippocampus and striatum; however, the impact of this genetic abnormality on system level brain functions, such as sleep and neural oscillation, has not been adequately investigated. Here, we show that chr16p11.2df/+ mice have altered sleep architecture, with increased wake time and reduced time in rapid eye movement (REM) and non-REM (NREM) sleep. Importantly, several measurements of REM sleep are significantly changed in deletion mice. The REM bout number and the bout number ratio of REM to NREM are decreased in mutant mice, suggesting a deficit in REM-NREM transition. The average REM bout duration is shorter in mutant mice, indicating a defect in REM maintenance. In addition, whole-cell patch clamp recording of the ventrolateral periaqueductal gray (vlPAG)-projecting gamma-aminobutyric acid (GABA)ergic neurons in the lateral paragigantocellular nucleus of ventral medulla of mutant mice reveal that these neurons, which are important for NREM–REM transition and REM maintenance, have hyperpolarized resting membrane potential and increased membrane resistance. These changes in intrinsic membrane properties suggest that these projection-specific neurons of mutant mice are less excitable, and thereby may play a role in deficient NREM–REM transition and REM maintenance. Furthermore, mutant mice exhibit changes in neural oscillation involving multiple frequency classes in several vigilance states. The most significant alterations occur in the theta frequency during wake and REM sleep.
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Sleep abnormalities and anxiety have been reported in 16p11.2+/− mice (Mills).
“Sleep abnormalities [69, 70] and anxiety [66] have been reported in 16p11.2+/− mice (Mills).”
From 16p11.2 Copy Number Variations and Neurodevelopmental Disorders (2020) · cites this paper as [69]
GABAergic neurons in the ventral medulla of 16p11.2+/− mice display hyperpolarized resting membrane potential and increased membrane resistance.
“Additionally, GABAergic neurons in the ventral medulla display hyperpolarized resting membrane potential and increased membrane resistance [69].”
From 16p11.2 Copy Number Variations and Neurodevelopmental Disorders (2020) · cites this paper as [69]
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16p11.2 Copy Number Variations and Neurodevelopmental Disorders
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- Authors
- Lu, H.-C., Pollack, H., Lefante, J. J., Mills, A. A., & Tian, D.
- Affiliations
- University of Southern California (US)
- Tulane University (US)
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Tian, Di
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-12
- Volume
- 42
- Issue
- 3
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC7850008
- OpenAlex
- W2904148038
- Cited by
- 22
- References
- 96
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- SLEEP (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Funders
- The Saban Research Institute of CHLA (8030-RRI007513)
- Simons Foundation Autism Research Initiative
- NIH
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep architecture, REM sleep, NREM sleep, neural oscillations, theta oscillations, ventrolateral periaqueductal gray, GABAergic neurons, membrane hyperpolarization, membrane resistance, neurodevelopmental disorders, sleep abnormalities
- MeSH terms
- Animals, Autistic Disorder, Chromosome Deletion, Chromosomes, Human, Pair 16, Disease Models, Animal, Electroencephalography, Humans, Male, Medulla Oblongata, Membrane Potentials, Intellectual Disability, Mice, Inbred C57BL, Mice, Transgenic, Sleep, REM, Polysomnography, Chromosome Disorders, Mice, GABAergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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