Cited by 165Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersEstrogen and related hormone effects

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Neuroendocrine Consequences of Prenatal Androgen Exposure in the Female Rat: Absence of Luteinizing Hormone Surges, Suppression of Progesterone Receptor Gene Expression, and Acceleration of the Gonadotropin-Releasing Hormone Pulse Generator1

Foecking, Eileen M., Szabo, Marta, Schwartz, Neena B., Levine, Jon E.·2005·Biology of Reproduction

DOI 10.1095/biolreprod.105.039800

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Abstract

Preovulatory GnRH and LH surges depend on activation of estrogen (E2)-inducible progesterone receptors (PGRs) in the preoptic area (POA). Surges do not occur in males, or in perinatally androgenized females. We sought to determine whether prenatal androgen exposure suppresses basal or E2-induced Pgr mRNA expression or E2-induced LH surges (or both) in adulthood, and whether any such effects may be mediated by androgen receptor activation. We also assessed whether prenatal androgens alter subsequent GnRH pulsatility. Pregnant rats received testosterone or vehicle daily on Embryonic Days 16-19. POA-hypothalamic tissues were obtained in adulthood for PgrA and PgrB (PgrA+B) mRNA analysis. Females that had prenatal exposure to testosterone (pT) displayed reduced PgrA+B mRNA levels (P < 0.01) compared with those that had prenatal exposure to vehicle (pV). Additional pregnant animals were treated with vehicle or testosterone, or with 5alpha-dihydrotestosterone (DHT). In adult ovariectomized offspring, estradiol benzoate produced a 2-fold increase (P < 0.05) in PgrA+B expression in the POA of pV females, but not in pT females or those that had prenatal exposure to DHT (pDHT). Prenatal testosterone and DHT exposure also prevented estradiol benzoate-induced LH surges observed in pV rats. Blood sampling of ovariectomized rats revealed increased LH pulse frequency in pDHT versus pV females (P < 0.05). Our findings support the hypothesis that prenatal androgen receptor activation can contribute to the permanent defeminization of the GnRH neurosecretory system, rendering it incapable of initiating GnRH surges, while accelerating basal GnRH pulse generator activity in adulthood. We propose that the effects of prenatal androgen receptor activation on GnRH neurosecretion are mediated in part via permanent impairment of E2-induced PgrA+B gene expression in the POA.

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Self-citation

Authors: Foecking, E. M., Szabo, M., Schwartz, N. B., & Levine, J. E.
Affiliations: Northwestern University (US)
Corresponding author: Levine, Jon E.
ORCID: Foecking, Eileen M.
Levine, Jon E.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2005-06-01
Volume: 72
Issue: 6
Pages: 1475-1483
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.105.039800
OpenAlex: W2114291118
Cited by: 165
References: 69
Citations by year: 2026: 2 · 2025: 2 · 2024: 8 · 2023: 2 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 10
FWCI: 10.90
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD044405, P01HD021921, U54HD041859, R01 HDO020677, P01HD21921)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: prenatal androgen exposure, testosterone, dihydrotestosterone, luteinizing hormone surge, GnRH pulsatility, preoptic area, androgen receptor, female rats, estradiol benzoate, LH pulse frequency
MeSH terms: Androgens, Animals, Estradiol, Female, Hormones, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Neurosecretory Systems, Ovulation, Pituitary Gland, Pregnancy, Prenatal Exposure Delayed Effects, Preoptic Area, Receptors, Progesterone, Dihydrotestosterone, Gene Expression, Rats, Sprague-Dawley, Rats

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Neuroendocrine Consequences of Prenatal Androgen Exposure in the Female Rat: Absence of Luteinizing Hormone Surges, Suppression of Progesterone Receptor Gene Expression, and Acceleration of the Gonadotropin-Releasing Hormone Pulse Generator1

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