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Cited by 759

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Growth factors in the extracellular matrix.

Taipale, Jussi, Keski‐Oja, Jorma·1997·The FASEB Journal
DOI 10.1096/fasebj.11.1.9034166
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Abstract

Much recent research has focused on the study of the expression of growth factor genes and on the identification of growth factor signaling mechanisms inside cells. However, growth factor signaling can also be regulated outside of cells by extracellular matrix proteins and proteolytic en‐zymes. The ability of extracellular proteins to pro‐cess complex information in the absence of new protein synthesis is illustrated in blood clotting and complement pathways. An increasing number of growth factors, including IGFs, FGFs, TGF‐β's, and HGF, have been found to associate with the extra‐cellular matrix proteins or with heparan sulfate. Rapid and localized changes in the activity of these factors can be induced by release from matrix stor‐age and/or by activation of latent forms. These growth factors, in turn, control cell proliferation, differentiation, and synthesis and remodeling of the extracellular matrix. It is therefore likely that much of the information processing necessary for construction of complex multicellular organisms occurs in the extracellular environment. This suggests that extracellular matrix plays a major role in the control of growth factor signaling.—Taipale, J., Keski‐ Oja, J. Growth factors in the extracellular matrix. FASEB J. 11, 51‐59 (1997)

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Metadata

Authors
Taipale, J., & Keski‐Oja, J.
Affiliations
Department of Virology University of Helsinki Helsinki Finland
Venue
The FASEB Journal
Publisher
Wiley
Published
1997-01
Volume
11
Issue
1
Pages
51-59
ISSN
  • 0892-6638
  • 1530-6860
DOI
10.1096/fasebj.11.1.9034166
Cited by
759
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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