Cutting back on the essentials: can manipulating intake of specific amino acids modulate health and lifespan
Open accessAbstract
With few exceptions, nutritional and dietary interventions generally impact upon both old-age quality of life and longevity. The life prolonging effects, commonly observed with dietary restriction reportedly are linked to alterations in protein intake and specifically limiting the dietary intake of certain essential amino acids. There is however a paucity of data methodically evaluating the various essential amino acids on health- and lifespan and the mechanisms involved. Rodent diets containing either lower methionine content, or tryptophan, than that found in commercially available chow, appear to elicit beneficial effects. It is unclear whether all of these favorable effects associated with restricted intake of methionine and tryptophan are due to their specific unique properties or if restriction of other essential amino acids, or proteins in general, may produce similar results. Considerably more work remains to be done to elucidate the mechanisms by which limiting these vital molecules may delay the onset of age-associated diseases and improve quality of life at older ages.
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In multiple model organisms, including rats and mice, dietary methionine restriction has consistently been shown to extend average and maximal life span, and protect against multiple chronic diseases, in particular cancer.
“This is important because in multiple model organisms, including rats and mice, dietary methionine restriction has consistently been shown to extend average and maximal life span, and protect against multiple chronic disease, in particular cancer (80).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [80]
Methionine restriction induces plasma elevations of adiponectin and FGF21, and reduces serum IGF-1, T4, and leptin concentration, which are all hormonal adaptations induced in long-lived rodents by calorie restriction as well.
“In addition, methionine restriction induces plasma elevations of adiponectin and FGF21, and reduces serum IGF-1, T4, and leptin concentration, which are all hormonal adaptations induced in long-lived rodents by calorie restriction as well (80).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [80]
In rodents, methionine restriction improves glucose metabolism, protects against obesity and hepatic steatosis, and reduces oxidative stress.
“In rodents, methionine restriction improves glucose metabolism, protects against obesity and hepatic steatosis, and reduces oxidative stress.”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [80]
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- Authors
- Brown-Borg, H. M., & Buffenstein, R.
- Affiliations
- Calico Life Sciences (US)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 39
- Pages
- 87-95
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC5571732
- OpenAlex
- W2507656378
- Cited by
- 70
- References
- 141
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 7
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (AG034206-HMBB, AG038509-HMBB)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- dietary restriction, essential amino acids, methionine restriction, lifespan extension, longevity, aging, age-related diseases, protein intake, quality of life in old age, rodent diet
- MeSH terms
- Healthy Aging, Aging, Amino Acids, Animals, Diet, Humans, Longevity, Methionine, Quality of Life, Tryptophan, Diet, Protein-Restricted, Caloric Restriction
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