Cited by 70Genetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthMuscle metabolism and nutrition

Cutting back on the essentials: can manipulating intake of specific amino acids modulate health and lifespan

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Brown-Borg, Holly M., Buffenstein, Rochelle·2017·Ageing Research Reviews

Abstract

With few exceptions, nutritional and dietary interventions generally impact upon both old-age quality of life and longevity. The life prolonging effects, commonly observed with dietary restriction reportedly are linked to alterations in protein intake and specifically limiting the dietary intake of certain essential amino acids. There is however a paucity of data methodically evaluating the various essential amino acids on health- and lifespan and the mechanisms involved. Rodent diets containing either lower methionine content, or tryptophan, than that found in commercially available chow, appear to elicit beneficial effects. It is unclear whether all of these favorable effects associated with restricted intake of methionine and tryptophan are due to their specific unique properties or if restriction of other essential amino acids, or proteins in general, may produce similar results. Considerably more work remains to be done to elucidate the mechanisms by which limiting these vital molecules may delay the onset of age-associated diseases and improve quality of life at older ages.

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Crossref · 10.1016/j.arr.2016.08.007

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  • In multiple model organisms, including rats and mice, dietary methionine restriction has consistently been shown to extend average and maximal life span, and protect against multiple chronic diseases, in particular cancer.

    “This is important because in multiple model organisms, including rats and mice, dietary methionine restriction has consistently been shown to extend average and maximal life span, and protect against multiple chronic disease, in particular cancer (80).”
  • Methionine restriction induces plasma elevations of adiponectin and FGF21, and reduces serum IGF-1, T4, and leptin concentration, which are all hormonal adaptations induced in long-lived rodents by calorie restriction as well.

    “In addition, methionine restriction induces plasma elevations of adiponectin and FGF21, and reduces serum IGF-1, T4, and leptin concentration, which are all hormonal adaptations induced in long-lived rodents by calorie restriction as well (80).”
  • In rodents, methionine restriction improves glucose metabolism, protects against obesity and hepatic steatosis, and reduces oxidative stress.

    “In rodents, methionine restriction improves glucose metabolism, protects against obesity and hepatic steatosis, and reduces oxidative stress.”

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Authors
Brown-Borg, H. M., & Buffenstein, R.
Affiliations
Calico Life Sciences (US)
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2017-10
Volume
39
Pages
87-95
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2507656378
Cited by
70
References
141
Citations by year
2025: 3 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 7
FWCI
0.94
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (AG034206-HMBB, AG038509-HMBB)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
dietary restriction, essential amino acids, methionine restriction, lifespan extension, longevity, aging, age-related diseases, protein intake, quality of life in old age, rodent diet
MeSH terms
Healthy Aging, Aging, Amino Acids, Animals, Diet, Humans, Longevity, Methionine, Quality of Life, Tryptophan, Diet, Protein-Restricted, Caloric Restriction

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