Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091

Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

Babcock, M., de Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., & Kaplan, J. (1997) · Science · doi:10.1126/science.276.5319.1709 · Cited by 921

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738

Delivery of bioactive molecules to mitochondria in vivo

Smith, R. A. J., Porteous, C. M., Gane, A. M., & Murphy, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931245100 · Cited by 725

Selective targeting of an antioxidant to mitochondria

Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00543.x · Cited by 466

Drug delivery to mitochondria: the key to mitochondrial medicine

Murphy, M. P., & Smith, R. A. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00069-1 · Cited by 429

Selective targeting of bioactive compounds to mitochondria

Murphy, M. P. (1997) · Trends in Biotechnology · doi:10.1016/s0167-7799(97)01068-8 · Cited by 366

Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia

Lodi, R., Cooper, J. A. D., Bradley, J. L., Manners, D. N., Styles, P., Taylor, D. J., & Schapira, A. H. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11492 · Cited by 352

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

Wilson, R. B., & Roof, D. M. (1997) · Nature Genetics · doi:10.1038/ng0897-352 · Cited by 345

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Trinucleotide Repeat Disorders

Orr, H. T., & Zoghbi, H. Y. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113042 · Cited by 1,394

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

Adlam, V. J., Harrison, J. C., Porteous, C. M., James, A. M., Smith, R. A. J., Murphy, M. P., & Sammut, I. A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3718com · Cited by 618

Targeting lipophilic cations to mitochondria

Murphy, M. P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.029 · Cited by 598

Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2609-7 · Cited by 558

Animal and human studies with the mitochondria‐targeted antioxidant MitoQ

Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 560

Intracellular iron transport and storage: from molecular mechanisms to health implications

Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526

Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

Ross, M. F., Kelso, G. F., Blaikie, F. H., James, A. M., Cochemé, H. M., Filipovska, A., Ros, T. D., Hurd, T. R., Smith, R. A. J., & Murphy, M. P. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0104-5 · Cited by 504

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s110 · Cited by 490

Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target

Barber, S. C., Mead, R. J., & Shaw, P. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.03.008 · Cited by 489

Mitochondria‐targeted antioxidants

Oyewole, A. O., & Birch‐Machin, M. A. (2015) · The FASEB Journal · doi:10.1096/fj.15-275404 · Cited by 467

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432

An Attempt to Prevent Senescence: A Mitochondrial Approach

Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430

Mitochondrial Diseases of the Brain

Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 426

Targeting antioxidants to mitochondria: A new therapeutic direction

Sheu, S., Nauduri, D., & Anders, M. W. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.10.007 · Cited by 417

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 411

Mitochondria-Targeted Small Molecule Therapeutics and Probes

Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399

Bioenergetic aspects of apoptosis, necrosis and mitoptosis

Skulachev, V. P. (2006) · APOPTOSIS · doi:10.1007/s10495-006-5881-9 · Cited by 391

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02250.x · Cited by 379

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

Jin, H., Kanthasamy, A., Ghosh, A., Anantharam, V., Kalyanaraman, B., & Kanthasamy, A. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.007 · Cited by 373

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130351 · Cited by 367

Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents

Szeto, H. H. (2006) · The AAPS Journal · doi:10.1208/aapsj080362 · Cited by 332

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

James, A. M., Cochemé, H. M., Smith, R. A. J., & Murphy, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501527200 · Cited by 353

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

Antonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Y., Izyumov, D. S., Khailova, L. S., Klishin, S. S., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120018 · Cited by 328

Cell-permeable, mitochondrial-targeted, peptide antioxidants

Szeto, H. H. (2006) · The AAPS Journal · doi:10.1007/bf02854898 · Cited by 316

Targeting Oxidative Stress in Central Nervous System Disorders

Patel, M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.06.007 · Cited by 312

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

Cassina, P., Cassina, A., Pehar, M., Castellanos, R., Gandelman, M., de León, A., Robinson, K. M., Mason, R. P., Beckman, J. S., Barbeito, L., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5308-07.2008 · Cited by 324

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives

Battogtokh, G., Choi, Y. S., Kang, D. S., Park, S. J., Shim, M. S., Huh, K. M., Cho, Y., Lee, J. Y., Lee, H. S., & Kang, H. C. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.05.006 · Cited by 318

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Apostolova, N., & Víctor, V. M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5952 · Cited by 311

Nanopreparations for organelle-specific delivery in cancer

Biswas, S., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.004 · Cited by 298

Inhibition of complex I of the electron transport chain causes O 2 − ·-mediated mitochondrial outgrowth

Koopman, W. J. H., Verkaart, S., Visch, H.-J., van der Westhuizen, F. H., Murphy, M. P., van den Heuvel, L. P., Smeitink, J. A. M., & Willems, P. H. G. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00607.2004 · Cited by 296

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P. I., Zhu, X., Wang, X., Lee, H., Nunomura, A., Petersen, R. B., Perry, G. L., & Smith, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.007 · Cited by 292

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

Biswas, S., Dodwadkar, N. S., Deshpande, P. P., & Torchilin, V. P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.009 · Cited by 281

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

Patten, D. A., Germain, M., Kelly, M., & Slack, R. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100498 · Cited by 286

Mitochondrial DNA damage and its potential role in retinal degeneration

Jarrett, S. G., Lin, H., Godley, B. F., & Boulton, M. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.09.001 · Cited by 279

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Stella, A. M. G., Schapira, T., Dinkova‐Kostova, A. T., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9775-9 · Cited by 273

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

Trnka, J., Blaikie, F. H., Smith, R. A. J., & Murphy, M. P. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.036 · Cited by 264

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

Lowes, D. A., Thottakam, B. M. V., Webster, N. R., Murphy, M. P., & Galley, H. F. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.003 · Cited by 261

Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

Zhao, K., Luo, G., Giannelli, S., & Szeto, H. H. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.08.022 · Cited by 251

GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology

Al‐Mahdawi, S., Pinto, R. M., Varshney, D., Lawrence, L., Lowrie, M. B., Hughes, S., Webster, Z., Blake, J. C., Cooper, J. A. D., King, R. H. M., et al. (2006) · Genomics · doi:10.1016/j.ygeno.2006.06.015 · Cited by 240

Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis

Dhanasekaran, A., Kotamraju, S., Kalivendi, S. V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., & Kalyanaraman, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404003200 · Cited by 241

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

He, B. J., Joiner, M.-L. A., Singh, M. V., Luczak, E. D., Dominic, P. S., Koval, O. M., Kutschke, W. J., Allamargot, C., Yang, J., Guan, X., et al. (2011) · Nature Medicine · doi:10.1038/nm.2506 · Cited by 243

CaMKII in the Cardiovascular System: Sensing Redox States

Erickson, J. R., He, B. J., Grumbach, I. M., & Anderson, M. E. (2011) · Physiological Reviews · doi:10.1152/physrev.00018.2010 · Cited by 244

Mitochondrial Medicine: Pharmacological targeting of mitochondria in disease

Armstrong, J. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707288 · Cited by 239

Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

James, A. M., Sharpley, M. S., Manas, A.-R. B., Frerman, F. E., Hirst, J., Smith, R. A. J., & Murphy, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611463200 · Cited by 262

Mitochondria-derived Reactive Oxygen Species Mediate Blue Light–induced Death of Retinal Pigment Epithelial Cells¶

King, A., Gottlieb, E., Brooks, D. G., Murphy, M. P., & Dunaief, J. L. (2004) · Photochemistry and Photobiology · doi:10.1562/le-03-17.1 · Cited by 243

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230

Mitochondrial trafficking and morphology in healthy and injured neurons

Chang, D. T. W., & Reynolds, I. J. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.09.003 · Cited by 235

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

Maio, N., & Rouault, T. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.09.009 · Cited by 222

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Ross, M. F., Prime, T. A., Abakumova, I., James, A. M., Porteous, C. M., Smith, R. A. J., & Murphy, M. P. (2008) · Biochemical Journal · doi:10.1042/bj20080063 · Cited by 206

The mitochondrial genome in human adaptive radiation and disease: On the road to therapeutics and performance enhancement

Wallace, D. C. (2005) · Gene · doi:10.1016/j.gene.2005.05.001 · Cited by 199

Epigenetics and Oxidative Stress in Aging

Guillaumet-Adkins, A., Yáñez, Y., Peris‐Díaz, M. D., Calabria, I., Palanca-Ballester, C., & Sandoval, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9175806 · Cited by 196

Friedreich Ataxia: Molecular Mechanisms, Redox Considerations, and Therapeutic Opportunities

Santos, R., Lefevre, S. D., Sliwa, D., Seguin, A., Camadro, J., & Lesuisse, E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3015 · Cited by 197

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

Ghosh, A., Chandran, K., Kalivendi, S. V., Joseph, J., Antholine, W. E., Hillard, C. J., Kanthasamy, A., Kanthasamy, A. G., & Kalyanaraman, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.028 · Cited by 194

Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide

Dhanasekaran, A., Kotamraju, S., Karunakaran, C., Kalivendi, S. V., Thomas, S., Joseph, J., & Kalyanaraman, B. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.016 · Cited by 193

A biochemical approach to the problem of aging: “Megaproject” on membrane-penetrating ions. The first results and prospects

Skulachev, V. P. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907120139 · Cited by 190

Coenzyme Q10 effects in neurodegenerative disease

Henchcliffe, C. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5212 · Cited by 189

Cellular response to infrared radiation involves retrograde mitochondrial signaling

Schröeder, P., Pohl, C., Calles, C., Marks, C., Wild, S., & Krutmann, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.002 · Cited by 183

Diabetic Nephropathy: Where Hemodynamics Meets Metabolism

Forbes, J. M., Fukami, K., & Cooper, M. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-949721 · Cited by 185

Mitochondria as a target in treatment

Frantz, M., & Wipf, P. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20554 · Cited by 183

Iron–sulfur protein maturation in human cells: evidence for a function of frataxin

Stehling, O., Elsässer, H.-P., Brückel, B., Mühlenhoff, U., & Lill, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh324 · Cited by 176

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

Akbar, M. D., Essa, M. M., Daradkeh, G., Abdelmegeed, M. A., Choi, Y., Mahmood, L., & Song, B. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.016 · Cited by 182

Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant

Asin-Cayuela, J., Manas, A.-R. B., James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.045 · Cited by 184

Mitochondria and cardioprotection

Lisa, F. D., Canton, M., Menabò, R., Kaludercic, N., & Bernardi, P. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9028-z · Cited by 177

Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria

Biswas, S., Dodwadkar, N. S., Piroyan, A., & Torchilin, V. P. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.032 · Cited by 171

Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics

Sharma, A., Liaw, K., Sharma, R. B., Zhang, Z., Kannan, S., & Kannan, R. M. (2018) · Theranostics · doi:10.7150/thno.29039 · Cited by 164

Targeted nanoparticles in mitochondrial medicine

Pathak, R., Kolishetti, N., & Dhar, S. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1305 · Cited by 165

Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy

Yang, N., Guan, Q.-W., Chen, F., Xia, Q., Yin, X., Zhou, H.-H., & Mao, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6687185 · Cited by 161

Brain mitochondrial dysfunction in aging, neurodegeneration and Parkinson's disease

Navarro, A. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00034 · Cited by 162

Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

V. Skulachev, M., N. Antonenko, Y., N. Anisimov, V., V. Chernyak, B., A. Cherepanov, D., A. Chistyakov, V., V. Egorov, M., G. Kolosova, N., A. Korshunova, G., G. Lyamzaev, K., et al. (2011) · Current Drug Targets · doi:10.2174/138945011795528859 · Cited by 156

Mitochondrial Oxidative Damage in Aging and Alzheimer′s Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics

Reddy, P. H. (2006) · BioMed Research International · doi:10.1155/jbb/2006/31372 · Cited by 154

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

Kumar, A., & Singh, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00206 · Cited by 157

Therapeutics development for triplet repeat expansion diseases

Prospero, N. A. D., & Fischbeck, K. H. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1690 · Cited by 149

Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor κB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants

Hughes, G., Murphy, M. P., & Ledgerwood, E. C. (2005) · Biochemical Journal · doi:10.1042/bj20050078 · Cited by 153

Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction

Moreira, P. I., Santos, M. S., & Oliveira, C. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1703 · Cited by 155

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

Xun, Z., Rivera, S., Ayala‐Peña, S., Lim, J. I., Budworth, H., Skoda, E. M., Robbins, P. D., Niedernhofer, L. J., Wipf, P., & McMurray, C. T. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.001 · Cited by 155

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

Yao, X., Carlson, D., Sun, Y., Ma, L., Wolf, S. E., Minei, J. P., & Zang, Q. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139416 · Cited by 148

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

Yin, X., Mańczak, M., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw045 · Cited by 144

Mitochondrial targeting of quinones: Therapeutic implications

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Kingdom

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