Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)

Shaked, G. M.; Kummer, M. P.; Lu, D. C.; Galvan, V.; Bredesen, D. E.; Koo, E. H.; Shaked, G. M.; Kummer, M. P.; Lu, D. C.; Galvan, V.; Bredesen, D. E.; Koo, E. H.

doi:10.1096/fj.05-5032fje

Cited by 132Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)

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Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., Koo, E. H., Shaked, G. M., Kummer, M. P. +4 more·2006·The FASEB Journal

DOI 10.1096/fj.05-5032fjePMC PMC1847355

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Abstract

Amyloid beta-peptide (Abeta) is postulated to play a central role in the pathogenesis of Alzheimer's disease. We recently proposed a pathway of Abeta-induced toxicity that is APP dependent and involves the facilitation of APP complex formation by Abeta. The APP-dependent component requires cleavage of APP at position 664 in the cytoplasmic domain, presumably by caspases or caspase-like proteases, with release of a potentially cytotoxic C31 peptide. In this study we show that Abeta interacted directly and specifically with membrane-bound APP to facilitate APP homo-oligomerization. Using chimeric APP molecules, this interaction was shown to take place between Abeta and its homologous sequence on APP. Consistent with this finding, we demonstrated that Abeta also facilitated the oligomerization of beta-secretase cleaved APP C-terminal fragment (C99). We found that the YENPTY domain in the APP cytoplasmic tail and contained within C31 is critical for this cell death pathway. Deletion or alanine- scanning mutagenesis through this domain significantly attenuated cell death apparently without affecting either APP dimerization or cleavage at position 664. This indicated that sequences within C31 are required after its release from APP. As the YENPTY domain has been shown to interact with a number of cytosolic adaptor molecules, it is possible that the interaction of APP, especially dimeric forms of APP, with these molecules contribute to cell death.

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Point mutations in the NPXY motif in the C-terminus of APP block toxicity.
“Remarkably, it was shown that extracellular Aβ1-42 was not toxic to APP knockout neurons [107] and that even point mutations in the NPXY motif in the C-terminus of APP block toxicity [169].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [169]

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Authors: Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., Koo, E. H., Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., & Koo, E. H.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2006-04-24
Volume: 20
Issue: 8
Pages: 1254-1256
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.05-5032fje
PMC: PMC1847355
OpenAlex: W2108938583
Cited by: 132
References: 44
Citations by year: 2026: 1 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 12 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 6
FWCI: 9.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AG05131)
Alzheimer's Association
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, Alzheimer's disease, APP, APP C-terminal fragments, caspase-like proteases, cell death
MeSH terms: Amino Acid Sequence, Animals, Membrane Proteins, Molecular Sequence Data, Peptide Fragments, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Cell Death, Protein Structure, Tertiary, Amino Acid Motifs, Cell Line, Tumor, Mice, Rats

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)

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