Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations
Open accessAbstract
A central question in Alzheimer's disease research is what role synaptic activity plays in the disease process. Synaptic activity has been shown to induce β-amyloid peptide release into the extracellular space, and extracellular β-amyloid has been shown to be toxic to synapses. We now provide evidence that the well established synaptotoxicity of extracellular β-amyloid requires γ-secretase processing of amyloid precursor protein. Recent evidence supports an important role for intraneuronal β-amyloid in the pathogenesis of Alzheimer's disease. We show that synaptic activity reduces intraneuronal β-amyloid and protects against β-amyloid-related synaptic alterations. We demonstrate that synaptic activity promotes the transport of the amyloid precursor protein to synapses using live cell imaging, and that the protease neprilysin is involved in reduction of intraneuronal β-amyloid with synaptic activity.
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Synaptic activity promotes APP transport down neurites to synapses.
“In fact synaptic activity was recently shown to promote APP transport down neurites to synapses [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
Synaptic activity reduces the intraneuronal pool of Aβ in vitro and in vivo.
“Moreover, synaptic activity was recently shown to reduce the intraneuronal pool of Aβ in vitro and in vivo [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
Amyloidogenic processing of APP, and potentially intraneuronal Aβ, is important in extracellular Aβ-induced synapse dysfunction.
“Recently, additional evidence pointed to the importance of amyloidogenic processing of APP, and therefore potentially intraneuronal Aβ, in extracellular Aβ-induced synapse dysfunction [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
Reduction of intraneuronal rather than extracellular Aβ correlates with synaptic improvement.
“A recent neurobiological study showed that it was reduction of intraneuronal rather than extracellular Aβ that correlated with synaptic improvement [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
Extracellular Aβ1-42 leads to marked up-regulation of endogenously generated Aβ42, which also occurs in neurons.
“Work in the 1990s had shown that extracellular Aβ1-42 led to marked up-regulation of endogenously generated Aβ42 [51, 211], which also occurs in neurons [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
Neprilysin is the protease shown to most efficiently degrade Aβ and is critical in synaptic activity-induced intraneuronal Aβ42 reduction.
“The protease shown to most efficiently degrade Aβ, neprilysin [81], was reported to be critical in synaptic activity-induced intraneuronal Aβ42 reduction [190].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [190]
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“, 2001), but when thiorphan was infused into the brain, only total levels of A 42 but not A 40 were elevated (Iwata et al., 2000; Belinson et al., 2008).”
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- Authors
- Tampellini, D., Rahman, N., Gallo, E. F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D. M., Lin, M. T., & Gouras, G. K.
- Affiliations
- Cornell University (US)
- Weill Cornell Medicine (US)
- Harvard University (US)
- Rockefeller University (US)
- Corresponding author
- Gouras, Gunnar K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-08-05
- Volume
- 29
- Issue
- 31
- Pages
- 9704-9713
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2763626
- OpenAlex
- W2094929105
- Cited by
- 127
- References
- 78
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Alzheimer's Association (AG09464)
- Weill Cornell Medical College
- National Institute on Aging (R01AG027140, AG09464, R01AG020729, K02AG028174, AG 20729, AG028174, AG027140, P01AG009464)
- National Institute of Neurological Disorders and Stroke (R01NS045677)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- synaptic activity, synaptotoxicity, neprilysin, Alzheimer's disease, synaptic plasticity, live-cell imaging
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Biological Transport, Active, Cells, Cultured, Extracellular Space, Hippocampus, Humans, Interneurons, Membrane Proteins, Mice, Transgenic, Synaptic Transmission, Neuronal Plasticity, Peptide Fragments, Receptors, Cell Surface, Synapses, Neprilysin, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Long-Term Potentiation, Intracellular Signaling Peptides and Proteins, Mice, Guanylate Kinases, Amyloid Precursor Protein Secretases, Protease Nexins, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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