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The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring

Bilbo, Staci D., Tsang, Verne·2010·The FASEB Journal
DOI 10.1096/fj.09-144014
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Abstract

Obesity is well characterized as a systemic inflammatory condition, and is also associated with cognitive disruption, suggesting a link between the two. We assessed whether peripheral inflammation in maternal obesity may be transferred to the offspring brain, in particular, the hippocampus, and thereby result in cognitive dysfunction. Rat dams were fed a high‐saturated‐fat diet (SFD), a high‐ trans ‐fat diet (TFD), or a low‐fat diet (LFD) for 4 wk prior to mating, and remained on the diet throughout pregnancy and lactation. SFD/TFD exposure significantly increased body weight in both dams and pups compared to controls. Microglial activation markers were increased in the hippocampus of SFD/TFD pups at birth. At weaning and in adulthood, proinflammatory cytokine expression was strikingly increased in the periphery and hippocampus following a bacterial challenge [lipopolysaccharide (LPS)] in the SFD/TFD groups compared to controls. Microglial activation within the hippocampus was also increased basally in SFD rats, suggesting a chronic priming of the cells. Finally, there were marked changes in anxiety and spatial learning in SFD/TFD groups. These effects were all observed in adulthood, even after the pups were placed on standard chow at weaning, suggesting these outcomes were programmed early in life.—Bilbo, S. D., Tsang, V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J. 24, 2104–2115 (2010). www.fasebj.org

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Metadata

Authors
Bilbo, S. D., & Tsang, V.
Venue
The FASEB Journal
Publisher
Wiley
Published
2010-02-02
Volume
24
Issue
6
Pages
2104-2115
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.09-144014
OpenAlex
W1998558885
Cited by
490
References
11
FWCI
10.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Bilbo, S. D., & Tsang, V. (2010). Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. The FASEB Journal. https://doi.org/10.1096/fj.09-144014

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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