mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, Matthew G.; Barrientos, Ruth M.; Biedenkapp, Joseph C.; Rudy, Jerry W.; Watkins, Linda R.; Maier, Steven F.

doi:10.1016/j.neurobiolaging.2005.03.013

Cited by 327Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model OrganismsPhagocytosis and Immune Regulation

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, Matthew G., Barrientos, Ruth M., Biedenkapp, Joseph C., Rudy, Jerry W., Watkins, Linda R., Maier, Steven F.·2006·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2005.03.013

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Abstract

In normal brain aging, CNS resident macrophages exhibit increased expression of major histocompatibility complex (MHC) II expression. However, the transcriptional basis for this observation has not been clarified nor have age-related alterations in pivotal pro-inflammatory genes been characterized. Age-related mRNA alterations in MHC II, MHC II accessory molecules and several pro-inflammatory mediators were measured in older (24 months) and younger (3 months) male F344xBN F1 rats. Real time RT-PCR was utilized to measure steady state mRNA levels in hippocampus. Older as compared to younger animals exhibited increased mRNA levels of MHC II, CD86, CIITA and IFN-gamma. Furthermore, IL-10 and CD200 mRNA, molecules that down-regulate macrophage activation, was decreased in older animals. The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS.

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Associated with these morphological alterations are biochemical changes, such as elevated expression of antigen presentation molecules (MHCII), Toll-like receptors, pro-inflammatory cytokines (IL-1β), reduced expression of regulatory molecules (CX3CR1 and CD200R), DNA methylation changes and telomere shortening.
“Associated with these morphological alterations are biochemical changes, such as elevated expression of antigen presentation molecules (MHCII), Toll-like receptors, pro-inflammatory cytokines (IL-1β), reduced expression of regulatory molecules (CX3CR1 and CD200R) (Frank et al, 2006;Maher et al, 2004), DNA methylation changes and telomere shortening (Flanary and Streit, 2003;Zannas et al, 2015).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Frank et al, 2006
Microglia under normal aging showed upregulation of genes associated with antigen presentation, such as MHCII, CD86, and CIITA, and suppression of anti-inflammatory genes, such as IL-10 and CD200.
“Microglia under normal aging (ie, aging in absence of neurodegeneration) showed upregulation of genes associated with antigen presentation, such as MHCII, CD86, and CIITA (Frank et al, 2006;Godbout et al, 2005;VanGuilder et al, 2011), and suppression of anti-inflammatory genes, such as IL-10 and CD200 (Frank et al, 2006).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Frank et al, 2006

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110 · see citing works
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works
Immune function of astrocytes
Dong, Y., & Benveniste, E. N. (2001) · Glia · doi:10.1002/glia.1107 · Cited by 1,286 · see citing works
Immune function of microglia
Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,281 · see citing works
Reactive microgliosis
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096 · see citing works
Gene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works
Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)
Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B., Homola, M. E., Streit, W. J., Brown, M. H., et al. (2000) · Science · doi:10.1126/science.290.5497.1768 · Cited by 1,022 · see citing works
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
Salomon, B. L., & Bluestone, J. A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.225 · Cited by 1,001 · see citing works
Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743 · see citing works
Genetic Control of MHC Class II Expression
Ting, J. P.-Y., & Trowsdale, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00696-7 · Cited by 583 · see citing works
Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment
Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works
Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
Guillemin, G. J., & Brew, B. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303114 · Cited by 520 · see citing works
CD200 and membrane protein interactions in the control of myeloid cells
Barclay, A. N., Wright, G. J., Brooke, G. P., & Brown, M. H. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02223-8 · Cited by 416 · see citing works
Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies
Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works
Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function
Wright, G. J., Puklavec, M. J., Willis, A. C., Hoek, R. M., Sedgwick, J. D., Brown, M. H., & Barclay, A. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00023-6 · Cited by 388 · see citing works
Altered antigen expression of microglia in the aged rodent CNS
Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364 · see citing works
The effects of aging on gene expression in the hypothalamus and cortex of mice
Jiang, C. H., Tsien, J. Z., Schultz, P. G., & Hu, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1930 · Cited by 318 · see citing works
Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation
Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00169-3 · Cited by 249 · see citing works
Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates
Sheffield, L. G., & Berman, N. E. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00168-1 · Cited by 234 · see citing works
Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.
(1990) · PubMed Central · Cited by 214 · see citing works
Increased microglial activation and protein nitration in white matter of the aging monkey☆
Sloane, J. A., Hollander, W., Moss, M. B., Rosene, D. L., & Abraham, C. R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00066-4 · Cited by 208 · see citing works
An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice
Ye, S.-M., & Johnson, R. W. (2001) · Neuroimmunomodulation · doi:10.1159/000049025 · Cited by 203 · see citing works
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
Morgan, T. E., Xie, Z., Goldsmith, S., Yoshida, T., Lanzrein, A.-S., Stone, D., Rozovsky, I., Perry, G., Smith, M. A., & Finch, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00334-0 · Cited by 195 · see citing works
Effects of ageing on microglia in the normal rat brain: immunohistochemical observations
Ogura, K., Ogawa, M., & Yoshida, M. (1994) · Neuroreport · doi:10.1097/00001756-199406020-00016 · Cited by 181 · see citing works
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents
Nicolle, M. M., Gonzalez, J., Sugaya, K., Baskerville, K. A., Bryan, D., Lund, K. C., Gallagher, M., & McKinney, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00374-8 · Cited by 177 · see citing works
Neurons, glia, and plasticity in normal brain aging
Finch, C. E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00051-4 · Cited by 170 · see citing works
Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits
Streit, W. J., & Sparks, D. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050097 · Cited by 167 · see citing works
Transcriptional regulation of the MHC class II antigen presentation pathway
Boss, J. M., & Jensen, P. E. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00015-8 · Cited by 163 · see citing works
T Cell Receptor Signaling: Beyond Complex Complexes
Huang, Y., & Wange, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400012200 · Cited by 156 · see citing works
Correlation analysis between frequencies of circulating antigen-specific IgG-bearing memory B cells and serum titers of antigen-specific IgG
Leyendeckers, H., Odendahl, M., Löhndorf, A., Irsch, J., Spangfort, M. D., Miltenyi, S., Hunzelmann, N., Assenmacher, M., Radbruch, A., & Schmitz, J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199904)29:04 · Cited by 135 · see citing works
Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress
Morgan, T. E., Rozovsky, I., Goldsmith, S. K., Stone, D. J., Yoshida, T., & Finch, C. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00120-2 · Cited by 126 · see citing works
Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment
Maier, S. F., & Watkins, L. R. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00079-x · Cited by 123 · see citing works
Self-citation
Neuronal Control of the Immune Response in the Central Nervous System
Neumann, H., & Wekerle, H. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199801000-00001 · Cited by 122 · see citing works
Immune response gene expression increases in the aging murine hippocampus
Terao, A., Apte-Deshpande, A. D., Dousman, L., Morairty, S. R., Eynon, B. P., Kilduff, T. S., & Freund, Y. R. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00317-x · Cited by 111 · see citing works
DNA microarray analysis of the aging brain
Prolla, T. A. (2002) · Chemical Senses · doi:10.1093/chemse/27.3.299 · Cited by 110 · see citing works
Regulation and Function of Class II Major Histocompatibility Complex, CD40, and B7 Expression in Macrophages and Microglia: Implications in Neurological Diseases
O'Keefe, G. M., Nguyen, V. T., & Benveniste, E. N. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100941 · Cited by 98 · see citing works
Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection
Petschner, F., Zimmermann, C., Strasser, A., Grillot, D., Núñez, G., & Pircher, H. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199802)28:02 · Cited by 77 · see citing works
Evidence That an OX-2-Positive Cell Can Inhibit the Stimulation of Type 1 Cytokine Production by Bone Marrow-Derived B7-1 (and B7-2)-Positive Dendritic Cells
Gorczynski, L. Y., Chen, Z., Hu, J., Kai, Y., Lei, J., Ramakrishna, V., & Gorczynski, R. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.774 · Cited by 76 · see citing works
Major Histocompatibility.Complex Molecule Expression in the Human Central Nervous System: Immunohistochemical Analysis of 40 Patients
Sobel, R. A., & Ames, M. B. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198801000-00003 · Cited by 67 · see citing works
Major Histocompatibility Class II Molecules in the CNS: Increased Microglial Expression at the Onset of Narcolepsy in a Canine Model
Tafti, M., Nishino, S., Aldrich, M. S., Liao, W., Dement, W. C., & Mignot, E. J.-M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04588.1996 · Cited by 54 · see citing works
Expression of IFN-gamma in Cerebrovascular Endothelial Cells from Aged Mice
Wei, Y., Kita, M., Shinmura, K., Yan, X.-Q., Fukuyama, R., Fushiki, S., & Imanishi, J. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/107999000312342 · Cited by 52 · see citing works
The class II transactivator CIITA is a transcriptional integrator
Fontes, J. D., Kanazawa, S., Nekrep, N., & Peterlin, B. M. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00232-4 · Cited by 49 · see citing works
The “chip” as a specific genetic tool
Watson, S. J., Meng, F., Thompson, R. C., & Akil, H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01080-5 · Cited by 45 · see citing works
Age‐related changes in murine CNS mRNA gene expression are modulated by dietary melatonin
Sharman, E. H., Sharman, K. G., Ge, Y., Lahiri, D. K., & Bondy, S. C. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00112.x · Cited by 44 · see citing works
Comparison of gene expression in old versus young rat hippocampus by cDNA array
Cho, K. S., Choi, J., Ha, C. M., Son, Y. J., Choi, W. S., & Lee, B. J. (2002) · Neuroreport · doi:10.1097/00001756-200203040-00008 · Cited by 21 · see citing works

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Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · see citing works
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Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works
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Bilbo, S. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.014.2009 · Cited by 652 · see citing works
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Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works
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Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638 · see citing works
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Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642 · see citing works
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.
Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., Deacon, R. M. J., Rawlins, J. N. P., & Perry, V. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.024 · Cited by 584 · see citing works
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Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
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Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299 · see citing works
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Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1748-05.2005 · Cited by 251 · see citing works
“Total RNA was isolated from hippocampal tissue based on the TRIzol method of Chomczynski and Sacchi (1987) and has been described in detail previously (Frank et al., 2005).”
MethodSelf-citation
Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging
Vukovic, J., Colditz, M. J., Blackmore, D. G., Ruitenberg, M. J., & Bartlett, P. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5925-11.2012 · Cited by 241 · see citing works
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia
Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.014 · Cited by 283 · see citing works
Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences
Hart, A. D., Wyttenbach, A., Hugh Perry, V., & Teeling, J. L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.11.006 · Cited by 230 · see citing works
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224 · see citing works
Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
Godbout, J. P., & Johnson, R. W. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.007 · Cited by 224 · see citing works
Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection
Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.002 · Cited by 226 · see citing works
Self-citation
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation
Wong, W. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00022 · Cited by 227 · see citing works
The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging
Vecchio, L. M., Meng, Y., Xhima, K., Lipsman, N., Hamani, C., & Aubert, I. (2018) · Brain Plasticity · doi:10.3233/bpl-180069 · Cited by 230 · see citing works
Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury
Witcher, K. G., Eiferman, D. S., & Godbout, J. P. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.002 · Cited by 222 · see citing works
DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling
Northcutt, A. L., Hutchinson, M. R., Wang, X., Baratta, M. V., Hiranita, T., Cochran, T. A., Pomrenze, M. B., Galer, E. L., Kopajtic, T. A., Li, C. M., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.177 · Cited by 220 · see citing works
Self-citation
Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
Huang, Y., Henry, C. J., Dantzer, R., Johnson, R. W., & Godbout, J. P. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.012 · Cited by 218 · see citing works
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory
Spencer, S. J., D’Angelo, H. M., Soch, A., Watkins, L. R., Maier, S. F., & Barrientos, R. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.014 · Cited by 213 · see citing works
Self-citation
Old Maids: Aging and Its Impact on Microglia Function
Koellhoffer, E. C., McCullough, L. D., & Ritzel, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040769 · Cited by 205 · see citing works
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198 · see citing works
Microglial Phenotype and Adaptation
Eggen, B. J. L., Raj, D. D. A., Hanisch, U., & Boddeke, H. W. G. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9490-4 · Cited by 176 · see citing works
Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation
Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works
Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176 · see citing works
Neuroinflammation and Memory: The Role of Prostaglandins
Hein, A. M., & O’Banion, M. K. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8066-z · Cited by 176 · see citing works
Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease
Lue, L., Kuo, Y., Beach, T. G., & Walker, D. G. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8106-8 · Cited by 175 · see citing works
Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease
Venneti, S., Wiley, C. A., & Kofler, J. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9142-2 · Cited by 168 · see citing works
RETRACTED: Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats
Cao, X., Ma, H., Wang, J.-K., Liu, F., Wu, B.-Y., Tian, A., Wang, L., & Tan, W. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.027 · Cited by 168 · see citing works
Retracted
Microglia: Neuroimmune-sensors of stress
Frank, M. G., Fonken, L. K., Watkins, L. R., & Maier, S. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.001 · Cited by 160 · see citing works
Self-citation
Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease
Monsonego, A., Imitola, J., Petrovic, S., Zota, V. E., Nemirovsky, A., Baron, R., Fisher, Y., Owens, T., & Weiner, H. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506209103 · Cited by 159 · see citing works
Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment
Kadish, I., Thibault, O., Blalock, E. M., Chen, K.-C., Gant, J. C., Porter, N. M., & Landfield, P. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4599-08.2009 · Cited by 152 · see citing works
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice
Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 154 · see citing works
Periodontal disease as a possible cause for Alzheimer's disease
Kamer, A. R., Craig, R. G., Niederman, R., Fortea, J., & de Leon, M. J. (2020) · Periodontology 2000 · doi:10.1111/prd.12327 · Cited by 154 · see citing works
Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes
Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148 · see citing works
Self-citation
Inflammation in Traumatic Brain Injury
Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., Hoisington, A. J., Scott, A. J., Potocki, E., Benros, M. E., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191150 · Cited by 150 · see citing works
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice
Kohman, R. A., Bhattacharya, T. K., Wojcik, E., & Rhodes, J. S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-114 · Cited by 146 · see citing works
Microglial activation in white matter lesions and nonlesional white matter of ageing brains
Simpson, J. E., Ince, P. G., Higham, C. E., Gelsthorpe, C., Fernando, M. S., Matthews, F. E., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., et al. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00890.x · Cited by 146 · see citing works
Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?
Lecours, C., Bordeleau, M., Cantin, L., Parent, M., Paolo, T. D., & Tremblay, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00282 · Cited by 143 · see citing works
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
Fonken, L. K., Frank, M. G., Kitt, M. M., D'Angelo, H. M., Norden, D. M., Weber, M. D., Barrientos, R. M., Godbout, J. P., Watkins, L. R., & Maier, S. F. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1161-16.2016 · Cited by 139 · see citing works
Self-citation
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge
O’Neil, S. M., Witcher, K. G., McKim, D. B., & Godbout, J. P. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0636-8 · Cited by 138 · see citing works
Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress
Blandino, P., Barnum, C. J., Solomon, L. G., Larish, Y., Lankow, B. S., & Deak, T. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.013 · Cited by 137 · see citing works
Insulin-like growth factor-1 in CNS and cerebrovascular aging
Sonntag, W. E., Deák, F., Ashpole, N. M., Tóth, P., Csiszár, A., Freeman, W. M., & Ungvari, Z. I. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00027 · Cited by 136 · see citing works
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment
VanGuilder, H. D., Bixler, G. V., Brucklacher, R. M., Farley, J. A., Yan, H., Warrington, J. P., Sonntag, W. E., & Freeman, W. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-138 · Cited by 132 · see citing works
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
Gamage, R. V., Wagnon, I. M., Rossetti, I., Childs, R., Niedermayer, G., Chesworth, R., & Gyengési, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577912 · Cited by 133 · see citing works
CD200‐CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation
Hernangómez, M., Mestre, L., Correa, F., Loría, F., Mecha, M., Iñigo, P. M., Docagne, F., Williams, R. O., Borrell, J. I., & Guaza, C. (2012) · Glia · doi:10.1002/glia.22366 · Cited by 130 · see citing works
Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation
Manich, G., Recasens, M., Valente, T., Almolda, B., González, B., & Castellano, B. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.030 · Cited by 126 · see citing works
IL‐4 attenuates the neuroinflammation induced by amyloid‐β in vivo and in vitro
Lyons, A., Griffin, R. J., Costelloe, C., Clarke, R. M., & Lynch, M. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04370.x · Cited by 129 · see citing works
The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128 · see citing works
A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia
Bilbo, S. D., Smith, S. H., & Schwarz, J. M. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9299-y · Cited by 127 · see citing works
Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
Buchanan, J. B., Sparkman, N. L., Chen, J., & Johnson, R. W. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.013 · Cited by 126 · see citing works
Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury
Zhang, B., Bailey, W. M., Braun, K. J., & Gensel, J. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.001 · Cited by 125 · see citing works
Multifaces of neuropeptide Y in the brain – Neuroprotection, neurogenesis and neuroinflammation
Malva, J. O., Xapelli, S., Baptista, S., Valero, J., Agasse, F., Ferreira, R., & Silva, A. P. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.001 · Cited by 123 · see citing works
A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly
Fard, M. T., & Stough, C. K. K. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00056 · Cited by 121 · see citing works
Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences
Godbout, J. P., & Johnson, R. W. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.010 · Cited by 120 · see citing works
Microglial activatory (immunoreceptor tyrosine‐based activation motif)‐ and inhibitory (immunoreceptor tyrosine‐based inhibition motif)‐signaling receptors for recognition of the neuronal glycocalyx
Linnartz‐Gerlach, B., & Neumann, H. (2012) · Glia · doi:10.1002/glia.22359 · Cited by 117 · see citing works
Microglia
Kofler, J., & Wiley, C. A. (2010) · Toxicologic Pathology · doi:10.1177/0192623310387619 · Cited by 116 · see citing works
Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats
Hovens, I. B., van Leeuwen, B. L., Nyakas, C. J., Heineman, E., van der Zee, E. A., & Schoemaker, R. G. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.11.009 · Cited by 113 · see citing works
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Crowe, E. P., Tuzer, F., Gregory, B. D., Donahue, G., Gosai, S. J., Cohen, J., Leung, Y. Y., Yetkin, E., Nativio, R., Wang, L.-S., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00208 · Cited by 110 · see citing works
Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation
Russo, R., Varano, G. P., Adornetto, A., Nucci, C., Corasaniti, M. T., Bagetta, G., & Morrone, L. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.064 · Cited by 110 · see citing works
Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK
Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works
Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease
Vinuesa, Á., Pomilio, C. J., Gregosa, A., Bentivegna, M., Presa, J., Bellotto, M., Saravia, F., & Beauquis, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.653651 · Cited by 111 · see citing works
Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline
Bilbo, S. D. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.001 · Cited by 108 · see citing works
Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
Frank, M. G., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.022 · Cited by 109 · see citing works
Self-citation
Aging-Dependent Changes in the Radiation Response of the Adult Rat Brain
Schindler, M. K., Forbes, M. E., Robbins, M. E. C., & Riddle, D. R. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.10.054 · Cited by 104 · see citing works
Alzheimer’s Disease: Mechanism and Approach to Cell Therapy
Amemori, T., Jendelová, P., Růžička, J., Urdzíková, L. M., & Syková, E. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125961 · Cited by 102 · see citing works
Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide
Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98 · see citing works
Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice
Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L., & Finsen, B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.006 · Cited by 107 · see citing works
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
Flores, J., Noël, A., Foveau, B., Beauchet, O., & LeBlanc, A. C. (2020) · Nature Communications · doi:10.1038/s41467-020-18405-9 · Cited by 98 · see citing works
Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior
Chabry, J., Nicolas, S., Cazareth, J., Murris, E., Guyon, A., Glaichenhaus, N., Heurteaux, C., & Petit-Paitel, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.018 · Cited by 96 · see citing works
Fate of microglia during HIV‐1 infection: From activation to senescence?
Chen, N. C., Partridge, A. T., Sell, C., Torres, C. A., & Martín‐García, J. (2016) · Glia · doi:10.1002/glia.23081 · Cited by 93 · see citing works
Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand
Fenn, A. M., Smith, K. M., Lovett‐Racke, A. E., Guerau‐de‐Arellano, M., Whitacre, C. C., & Godbout, J. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.007 · Cited by 95 · see citing works

Regulation of Interleukin -6 Gene Expression in the Brain of Aged Mice
Ye, S. (2000) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function
Costello, D. A., Keenan, K., McManus, R. M., Falvey, A., & Lynch, M. A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.001 · Cited by 32 · see citing works
IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice
Herrero, C., Marqués, L., Lloberas, J., & Celada, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11696 · Cited by 162 · see citing works
Increased chemokine gene expression during aging in the murine brain
Felzien, L. K., McDonald, J. T., Gleason, S. M., Berman, N. E. J., & Klein, R. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03090-0 · Cited by 51 · see citing works
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment
VanGuilder, H. D., Bixler, G. V., Brucklacher, R. M., Farley, J. A., Yan, H., Warrington, J. P., Sonntag, W. E., & Freeman, W. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-138 · Cited by 132 · see citing works

Authors: Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Frank, Matthew G.
ORCID: Frank, Matthew G.
Barrientos, Ruth M.
Biedenkapp, Joseph C.
Rudy, Jerry W.
Watkins, Linda R.
Maier, Steven F.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2006-05
Volume: 27
Issue: 5
Pages: 717-722
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2005.03.013
OpenAlex: W2078514181
Cited by: 327
References: 51
Citations by year: 2026: 7 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 13 · 2016: 24 · 2015: 18 · 2014: 17 · 2013: 13 · 2012: 18
FWCI: 6.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f32mh064339-03)
National Institute of Mental Health (5 F32 MH064339-03)
National Institute on Drug Abuse (F32DA015591)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: brain aging, MHC class II, microglia, pro-inflammatory genes, hippocampus, CD86, CIITA, interferon-gamma, IL-10, CD200, macrophage activation, neuroinflammation, gene expression
MeSH terms: Aging, Animals, Brain, Genes, MHC Class II, Inflammation, Male, Neurons, Rats, Inbred F344, Receptors, Immunologic, RNA, Messenger, Antigens, CD, Up-Regulation, DNA Primers, DNA, Complementary, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Rats

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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

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