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Cited by 92

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

High ability of apolipoprotein E4 to stabilize amyloid‐β peptide oligomers, the pathological entities responsible for Alzheimer's disease

Cerf, Emilie, Gustot, Adelin, Goormaghtigh, Erik, Ruysschaert, Jean-Marie, Raussens, Vincent·2011·The FASEB Journal
DOI 10.1096/fj.10-175976
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Abstract

Nowadays, the emerging role of amyloid‐β peptide (Aβ) oligomers in Alzheimer's disease (AD) is widely accepted, putting aside the old idea that fibrils are the primary entities responsible for the onset of the disease. Besides, carrying the E4 isoform of apolipoprotein E (apoE) represents the highest risk of developing AD. Nevertheless, the involvement of apoE4 in AD remains confusing. The goal of this study was to bring new insights into the role of apoE4 in Aβ aggregation. We used infrared spectroscopy, thioflavin T fluorescence, and Western blots to evaluate the influence of apoE isoforms on Aβ aggregation in vitro. Comparing Aβ controls with Aβ incubated either with the apoE3 or apoE4 isoform, we report a 30% reduction of the Aβ fibrillar content, whereas the oligomeric content is 2 times higher on incubation with the pathological isoform apoE4. ApoE4 would bind and block Aβ in its oligomeric conformation, inhibiting further formation of less toxic fibrillar forms of Aβ. While previous studies mostly correlated E4 with fibrils, our report underlines a link between apoE4 and Aβ oligomers and therefore reconciles apoE4 with the new amyloid cascade hypothesis. Our observations suggest that apoE4 strongly stabilizes Aβ oligomers, the pathological species responsible for Alzheimer's disease.—Cerf, E., Gustot, A., Goormaghtigh, E., Ruysschaert, J.‐M., Raussens, V. High ability of apolipoprotein E4 to stabilize amyloid‐β peptide oligomers, the pathological entities responsible for Alzheimer's disease. FASEB J. 25, 1585–1595 (2011). www.fasebj.org

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Metadata

Authors
Cerf, E., Gustot, A., Goormaghtigh, E., Ruysschaert, J.-M., & Raussens, V.
Affiliations
Structure and Function of Biological Membranes Center for Structural Biology and Bioinformatics Université Libre de Bruxelles Brussels Belgium
Venue
The FASEB Journal
Publisher
Wiley
Published
2011-01-25
Volume
25
Issue
5
Pages
1585-1595
ISSN
  • 0892-6638
  • 1530-6860
DOI
10.1096/fj.10-175976
Cited by
92
References
14
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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