The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn Injury
Open accessAbstract
A bilayer artificial skin composed of a temporary Silastic epidermis and a porous collagen-chondroitn 6-sulfate fibrillar dermis, which is not removed, has been used to physiologically close up to 60% of the body surface following prompt excision of burn wounds in ten patients whose total burn size covered 50--95% body surface area (BSA). Following grafting, the dermal portion is populated with fibroblasts and vessels from the wound bed. The anatomic structure of the artificial dermis resembles normal dermis and serves as a template for the synthesis of new connective tissue and the formation of a "neodermis," while it is slowly biodegraded. This artificial skin has physiologically closed excised burn wounds for periods of time up to 46 days before the Silastic epidermis was removed. At the time of election when donor sites are ready for reharvesting, the Silastic epidermis is removed from the vascularized artificial dermis and replaced with 0.004 autoepidermal graft in sheet or meshed form. Clinical and histologic experience in a relatively short follow-up period (2--16 months) indicates that "neodermis" retains some of the anatomic characteristics and behavior of normal dermis, thus promising improvement in the functional and cosmetic results, as well as providing physiologic function as a skin substitute. The artificial skin is easily sterilized and stored at room temperature, capable of large scale production, and immediately available for grafting, indicating its potential for easy and relatively economic use in the burn patient.
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Citations
Cites
Design of an artificial skin. Part III. Control of pore structure
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Self-citation
Cited by
Yannas, I. V., Lee, E., Orgill, D. P., Skrabut, E. M., & Murphy, G. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.933 · Cited by 972
Self-citationTissue Engineering and Regenerative Medicine: History, Progress, and Challenges
Berthiaume, F., Maguire, T. J., & Yarmush, M. L. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114257 · Cited by 734
Extracellular matrix-derived biomaterials in engineering cell function
Xing, H., Lee, H., Luo, L., & Kyriakides, T. R. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107421 · Cited by 302
“The porous material allowed cells to migrate towards the open wound and begin regenerative processes (Burke et al., 1982).”
BackgroundEngineering the multiscale complexity of vascular networks
O’Connor, C., Brady, E., Zheng, Y., Moore, E., & Stevens, K. R. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00447-8 · Cited by 271
Porcine Models of Cutaneous Wound Healing
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Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options
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Stem cells and tissue engineering: past, present, and future
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Application of decellularized bone matrix as a bioscaffold in bone tissue engineering
Amirazad, H., Dadashpour, M., & Zarghami, N. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-021-00282-5 · Cited by 154
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Self-citationDecellularized scaffolds in regenerative medicine
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From Grafts to Human Bioengineered Vascularized Skin Substitutes
Oualla-Bachiri, W., Fernández-González, A., Quiñones-Vico, M. I., & Arias-Santiago, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218197 · Cited by 69
Collagen in Dermal Wound Repair
McPherson, J. M., & Piez, K. A. (1988) · The Molecular and Cellular Biology of Wound Repair · doi:10.1007/978-1-4615-1795-5_20 · Cited by 39
Klicznik, M. M., Benedetti, A., Gail, L. M., Varkhande, S. R., Holly, R., Laimer, M., Stoecklinger, A., Sir, A., Reitsamer, R., Neuper, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67430-7 · Cited by 20
Metadata
- Authors
- BURKE, J. F., YANNAS, I. V., QUINBY, W. C., BONDOC, C. C., & JUNG, W. K.
- Venue
- Annals of Surgery
- Published
- 1981-10
- Volume
- 194
- Issue
- 4
- Pages
- 413-428
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2006875835
- Cited by
- 1,250
- References
- 1
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
