Pyramidal cells ensheathed by perineuronal nets in human motor and somatosensory cortex
Abstract
This study presents data concerning the distribution of chondroitin sulphate proteoglycan-immunoreactive perineuronal nets in sensorimotor areas (Brodmann's areas 3, 1, 2 and 4) of the human cerebral cortex. In addition to previously described subpopulations of nonpyramidal neurons in neocortical areas, many large or medium-sized pyramidal cells in layers III and V, including Betz cells in the motor cortex, were shown to be net-associated and constitute about one-third of all net-associated cells. Such widespread occurrence of perineuronal nets around subpopulations of pyramidal cells is known from macaque monkeys but not from the cortex of myomorph rodents. Thus it appears that a certain proportion of net-associated pyramidal cells distinguishes individual cortical areas in highly evolved primates. This ratio may vary also with respect to species-dependent organization principles in nonprimate mammals.
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PNNs surround inhibitory fast spiking parvalbumin-positive GABAergic interneurons and are also associated with excitatory pyramidal neurons in the cerebral cortex.
“PNNs surround inhibitory fast spiking parvalbumin-positive GABAergic interneurons12–14, but are also associated with further subpopulations, for example excitatory pyramidal neurons in the cerebral cortex15,16.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [15]
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- Authors
- Hausen, D., Brückner, G., Drlicek, M., Härtig, W., Brauer, K., & Bigl, V.
- Affiliations
- Leipzig University (DE)
- ORCID
- Härtig, Wolfgang
- Venue
- NeuroReport
- Published
- 1996-07
- Volume
- 7
- Issue
- 11
- Pages
- 1725-1729
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2063230836
- Cited by
- 59
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- perineuronal nets, chondroitin sulfate proteoglycans, pyramidal neurons, Betz cells, motor cortex, somatosensory cortex, sensorimotor cortex, human cerebral cortex, cortical layers, non-pyramidal neurons, myomorph rodents
- MeSH terms
- Aged, Aged, 80 and over, Cell Count, Extracellular Matrix, Female, Humans, Immunohistochemistry, Male, Middle Aged, Motor Cortex, Somatosensory Cortex, Pyramidal Cells
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