CoChat
Sign Up
Cited by 93Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat

Alpár, Alán, Gärtner, Ulrich, Härtig, Wolfgang, Brückner, Gert·2006·Brain Research
DOI 10.1016/j.brainres.2006.08.069
Open this paper in CoChat — free account

Abstract

Perineuronal nets are lattice-like accumulations of extracellular matrix components around the cell body and perisomatic portion of certain neurons. Whereas interneurons associated to this specific neuron-associated sheath have been elaborately classified, less effort has been undertaken to describe the occurrence of perineuronal nets around pyramidal neurons. Our aim was to give a detailed and comparative description of the occurrence of net-associated pyramidal cells throughout the rat neocortex as well as to systematically and comparatively analyze the relation of main projection types of principal neurons to the presence of perineuronal nets. The present study revealed that perineuronal nets stained with WFA were associated rather rarely to pyramidal cells compared to interneurons in layers II/III and V/VI of rat neocortex. However, their frequency was considerably different between various cortical areas with a maximum in visual cortex and with a minimum in secondary motor cortices. Further analysis revealed that neuron-associated matrix sheaths around principal cells were more common in the primary than in the secondary fields of corresponding areas and they were more numerous in infra-than in supragranular layers in most regions. Subfields of cortical areas also differed regarding the occurrence of net-associated principal cells, and the subtlety of cortical representation seemed to correlate with the frequency of perineuronal nets around pyramidal neurons in the primary somatosensory cortex. It appears that net-associated pyramidal cells do not have a projection pattern restricted to distinct target regions. Rather a functional heterogeneity of the pyramidal cell population contributing to specific intra-or subcortical projections is suggested.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2006.08.069

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • WFA-positive nets are localized around different neuronal types, including parvalbumin-expressing GABAergic neurons in cortical areas, cortical pyramidal neurons, glutamatergic neurons in cerebellar nuclei, and glycinergic neurons of the medial nucleus of the trapezoid body.

    “WFA-positive nets are localised around different neuronal types, such as parvalbumin-expressing GABAergic neurons in cortical areas (see above), as well as cortical pyramidal neurons (Alpár et al., 2006;Hartig et al., 2001;Takahashi-Iwanaga et al., 1998;Wegner et al., 2003), glutamatergic neurons in the cerebellar nuclei (Carulli et al., 2006) and glycinergic neurons of the medial nucleus of the”

    From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Alpár et al., 2006

Cites

Flagged first, then by citations

1 of the 45 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Alpár, A., Gärtner, U., Härtig, W., & Brückner, G.
Affiliations
  • Semmelweis University (HU)
  • Leipzig University (DE)
Corresponding author
Alpár, Alán
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2006-11
Volume
1120
Issue
1
Pages
13-22
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2006.08.069
OpenAlex
W2077740690
Cited by
93
References
45
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 8 · 2017: 13 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 3
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universität Leipzig
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
perineuronal nets, pyramidal neurons, neocortex, extracellular matrix, cortical layers, primary motor cortex, visual cortex, primary somatosensory cortex, neuronal projection patterns, rats
MeSH terms
Agglutinins, Animals, Biotin, Dextrans, Female, Histocytochemistry, Male, Nerve Net, Neural Pathways, Rats, Wistar, Pyramidal Cells, Neocortex, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review