Localization of leptin receptor mRNA expression in mouse brain
Abstract
The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in the dentate gyrus and CA1, and was detected at low levels in piriform cortex and the medial margin of the medial habenular nucleus. The localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptor is expressed on neuropeptide Y-containing neurones.
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Leptin may modulate sensory processing at higher gustatory and olfactory processing steps, as indicated by the presence of leptin receptors and leptin-induced Fos expression in the nucleus of the solitary tract, parabrachial nucleus, olfactory bulb, and insular and piriform cortices of rodents.
“Leptin may also modulate sensory processing at higher gustatory and olfactory processing steps, as indicated by the presence of leptin receptors and leptin-induced Fos expression in the nucleus of the solitary tract, parabrachial nucleus, olfactory bulb, and insular and piriform cortices of rodents”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [86]
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“Beyond the hypothalamic regions, LepRb is also found in extra-hypothalamic areas, such as the midbrain and brainstem (Huang et al., 1996).”
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“The hippocampus contains receptors for several hormonal signals of relevance to energy status, including leptin [111,112], ghrelin [113,114], GLP-1 [115], and insulin [116,117].”
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“For determination of SOCS-3 and Ob-R, we used specific cDNA fragments as described previously (Richard et al., 1996; Huang et al., 1996; Lebel et al., 2000).”
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“Receptors are found in many regions of the CNS (Huang et al., 1996; De Matteis and Cinti, 1998; Shioda et al., 1998; Funahashi et al., 1999), not just in the arcuate nucleus, and in peripheral tissues, such as liver, adrenal, and peripheral endothelial cells (Tartaglia et al.”
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SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats
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Hypothalamic malonyl-CoA and the control of food intake
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“Leptin receptors are abundantly expressed in the hypothalamic nuclei, such as the Arc nucleus containing NPY/AgRP and POMC/CART neurons [12,22,25,39,40,44,63,64,79,95].”
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BackgroundLeptin action on nonneuronal cells in the CNS: potential clinical applications
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- Authors
- Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., & Storlien, L.
- Affiliations
- University of Wollongong (AU)
- ORCID
- Venue
- NeuroReport
- Published
- 1996-11
- Volume
- 7
- Issue
- 15
- Pages
- 2635-2638
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2061211669
- Cited by
- 160
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 2 · 2012: 9
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- leptin receptor, mRNA expression, brain localization, hypothalamus, arcuate nucleus, median eminence, hippocampus, dentate gyrus, CA1, piriform cortex, medial habenula, neuropeptide Y neurons, C57 mice
- MeSH terms
- Animals, Base Sequence, Brain, Carrier Proteins, Female, Male, Mice, Inbred C57BL, Molecular Sequence Data, Receptors, Cell Surface, In Situ Hybridization, Mice, Receptors, Leptin
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