Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

Patel, Nilay V.; Gordon, Marcia N.; Connor, Karen E.; Good, Robert A.; Engelman, Robert W.; Mason, Jerimiah; Morgan, David G.; Morgan, Todd E.; Finch, Caleb E.

doi:10.1016/j.neurobiolaging.2004.09.014

Cited by 329Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetics, Aging, and Longevity in Model Organisms

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

Patel, Nilay V., Gordon, Marcia N., Connor, Karen E., Good, Robert A., Engelman, Robert W., Mason, Jerimiah, Morgan, David G., Morgan, Todd E. +1 more·2005·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2004.09.014

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Abstract

Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging processes are attenuated in laboratory mammals by caloric restriction (CR), we examined the effects of short-term CR in two AD-transgenic mice, APP(swe/ind) (J20) and APP(swe) + PS1(M146L) (APP + PS1). CR substantially decreased the accumulation of Abeta-plaques in both lines: by 40% in APP(swe/ind) (CR, 6 weeks), and by 55% in APP + PS1 (CR, 14 weeks). CR also decreased astrocytic activation (GFAP immunoreactivity). These influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression.

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SIRT1 has protective effects on AD.
“Patel et al. elucidated the protective effects of SIRT1 on AD, showing that caloric restrictions diminished plaque formation and Aβ levels in the brains of AD transgenic mice models [171].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [171]
Caloric restriction diminished plaque formation and Aβ levels in the brains of AD transgenic mice models.
“Patel et al. elucidated the protective effects of SIRT1 on AD, showing that caloric restrictions diminished plaque formation and Aβ levels in the brains of AD transgenic mice models [171].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [171]
Deficiencies in SIRT1 are correlated with enhanced levels of phosphorylated tau in neurons and the number of neurofibrillary tangles in the brains of AD subjects.
“Consequently, deficiencies in SIRT1 have also been correlated with enhanced levels of phosphorylated tau in the neurons and the number of neurofibrillary tangles in the brains of AD subjects [171,172].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [171]

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Authors: Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E.
Affiliations: University of Southern California (US)
University of South Florida (US)
Corresponding author: Morgan, Todd E.
ORCID: Gordon, Marcia N.
Connor, Karen E.
Morgan, David G.
Morgan, Todd E.
Finch, Caleb E.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2005-07
Volume: 26
Issue: 7
Pages: 995-1000
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2004.09.014
OpenAlex: W2089714642
Cited by: 329
References: 36
Citations by year: 2026: 13 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 19 · 2018: 15 · 2017: 14 · 2016: 16 · 2015: 8 · 2014: 11 · 2013: 20 · 2012: 17
FWCI: 10.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: caloric restriction, Alzheimer's disease, amyloid plaques, APP transgenic mice, APPswe, astrocyte activation, glial fibrillary acidic protein, dietary intervention, aging, disease progression
MeSH terms: CD68 Molecule, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Membrane Proteins, Mice, Transgenic, RNA, Messenger, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Amyloid beta-Peptides, Neurofibrillary Tangles, Reverse Transcriptase Polymerase Chain Reaction, Caloric Restriction, Mice, Presenilin-1, Plaque, Amyloid

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Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

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