The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Stimulant Medications
Open accessAbstract
OBJECTIVE: To review the short- and long-term safety and efficacy of stimulants for the treatment of children with attention-deficit/hyperactivity disorder (ADHD). METHOD: A Medline search was conducted for both randomized controlled trials and reviews to determine the efficacy and safety of stimulant drugs for treating children with ADHD. Information was obtained on adverse events associated with their use, including their impact on height and weight gain during childhood. Animal data were reviewed for information on tolerance, sensitization, and the impact of high-dose stimulant effects on neurons and on the development of hepatic tumors. Human data on dopamine transporter occupancy by stimulants were also included. RESULTS: Stimulant treatment studies show robust short-term efficacy and a good safety profile. Longer-term studies are few in number but have produced no conclusive evidence that careful therapeutic use of these medications is harmful. CONCLUSION: Current evidence indicates that stimulants show efficacy and safety in studies lasting up to 24 months.
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“These interventions result in significant benefits for children with ADHD in multiple domains of functioning (Conners, 2002; Greenhill, Halperin, & Abikoff, 1999; Pelham, Jr., Wheeler, & Chronis, 1998; Pelham, Jr. & Fabiano, 2008; Spencer et al., 1996).”
From The influences of environmental enrichment, cognitive enhancement, and physical exercise on brain development: Can we alter the developmental trajectory of ADHD? (2011) · cites this paper as Greenhill et al., 1999
Citations
Cites
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Goldman, L. S. (1998) · JAMA · doi:10.1001/jama.279.14.1100 · Cited by 1,082
THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE
Bradley, C. (1937) · American Journal of Psychiatry · doi:10.1176/ajp.94.3.577 · Cited by 1,035
Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1325 · Cited by 885
Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle
SPENCER, T., BIEDERMAN, J., WILENS, T., HARDING, M., O'DONNELL, D., & GRIFFIN, S. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199604000-00008 · Cited by 830
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677
Dulcan, M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199710001-00007 · Cited by 628
Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status
Mannuzza, S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810250079012 · Cited by 549
A REVIEW OF STIMULANT DRUG RESEARCH WITH HYPERACTIVE CHILDREN
Barkley, R. A. (1977) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1977.tb00425.x · Cited by 542
Barkley, R. A., McMurray, M. B., EDELBROCK, C. S., & Robbins, K. (1990) · PEDIATRICS · doi:10.1542/peds.86.2.184 · Cited by 481
Flagged first, then by citations
Research works printed but not linked: 9
- Angold A, Costello E (in press), Stimulant treatment for children: a community perspective. Pediatrics
- Battaglia, 1987, 3,4-Methylenedioxymethamphetamine and 3,4-Methylenedioxymethamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites, J Pharmacol Exp Ther, 242, 911, 10.1016/S0022-3565(25)39191-3 · DOI
- Feussner G (1998), Diversion, trafficking, and abuse of methylphenidate. In: NIH Consensus Development Conference: Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder, Program and Abstracts, pp 201–205
- Jensen PS, Kettle L, Roper MT et al. (in press). Are stimulants overprescribed? Treatment of ADHD in four US communities. J Am Acad Child Adolesc Psychiatry
- MTA Cooperative Group (in press), Fourteen-month randomized clinical trial of treatment strategies for attention deficit hyperactivity disorder. Arch Gen Psychiatry
- Schachar RJ, Ickowicz A, Tannock R (in press), Pharmacotherapy of ADHD. In: Handbook of Disruptive Behavior Disorders, Quay H, Hogan A, eds. New York: Plenum, pp 555–565
- US Drug Enforcement Administration, Office of Diversion Control (1996), Conference Report: Stimulant Use in the Treatment of ADHD. Washington, DC
- Vitiello B, Burke L (in press), Generic methylphenidate versus brand Ritalin: which should be used? In: Ritalin: Theory and Practice, 2nd ed, Greenhill L, Osman B, eds. Larchmont, NY: Mary Ann Liebert
- Winsberg, 1987, Is there dosedependent tolerance associated with chronic methylphenidate therapy in hyperactive children: oral dose and plasma concentrations, Psychopharmacol Bull, 23, 107
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Sorted by citations
Attention-Deficit, S. O., & Disorder, H. (2001) · Pediatrics · doi:10.1542/peds.108.4.1033 · Cited by 636
(2001) · Europe PMC (PubMed Central) · Cited by 393
Effective Treatment for Mental Disorders in Children and Adolescents
Burns, B. J., Hoagwood, K., & Mrazek, P. J. (1999) · Clinical Child and Family Psychology Review · doi:10.1023/a:1021826216025 · Cited by 385
The top and the bottom of ADHD: a neuropsychological perspective
Sergeant, J. A., Geurts, H., Huijbregts, S., Scheres, A., & Oosterlaan, J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.004 · Cited by 372
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Ding, Y.-S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.006 · Cited by 368
Metadata
- Authors
- GREENHILL, L. L., HALPERIN, J. M., & ABIKOFF, H.
- Affiliations
- Queens College, CUNY (US)
- Corresponding author
- GREENHILL, LAURENCE L.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 38
- Issue
- 5
- Pages
- 503-512
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W4250858368
- Cited by
- 268
- References
- 54
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 10
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (5-UO1-MH5045402, U01MH050454)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Arts and Humanities › Philosophy › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- stimulant medication, attention deficit hyperactivity disorder, children, long-term safety, efficacy, adverse events, weight gain, height gain, tolerance (pharmacology and immunology), sensitization, liver tumors
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Constitution, Child, Humans, Weight Gain, Treatment Outcome
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