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Cited by 268Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesNeuroethics, Human Enhancement, Biomedical Innovations

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Stimulant Medications

Open access
GREENHILL, LAURENCE L., HALPERIN, JEFFREY M., ABIKOFF, HOWARD·1999·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/00004583-199905000-00011
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Abstract

OBJECTIVE: To review the short- and long-term safety and efficacy of stimulants for the treatment of children with attention-deficit/hyperactivity disorder (ADHD). METHOD: A Medline search was conducted for both randomized controlled trials and reviews to determine the efficacy and safety of stimulant drugs for treating children with ADHD. Information was obtained on adverse events associated with their use, including their impact on height and weight gain during childhood. Animal data were reviewed for information on tolerance, sensitization, and the impact of high-dose stimulant effects on neurons and on the development of hepatic tumors. Human data on dopamine transporter occupancy by stimulants were also included. RESULTS: Stimulant treatment studies show robust short-term efficacy and a good safety profile. Longer-term studies are few in number but have produced no conclusive evidence that careful therapeutic use of these medications is harmful. CONCLUSION: Current evidence indicates that stimulants show efficacy and safety in studies lasting up to 24 months.

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Crossref · 10.1097/00004583-199905000-00011

Cites

55 of 55 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 9

  1. Angold A, Costello E (in press), Stimulant treatment for children: a community perspective. Pediatrics
  2. Battaglia, 1987, 3,4-Methylenedioxymethamphetamine and 3,4-Methylenedioxymethamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites, J Pharmacol Exp Ther, 242, 911, 10.1016/S0022-3565(25)39191-3 · DOI
  3. Feussner G (1998), Diversion, trafficking, and abuse of methylphenidate. In: NIH Consensus Development Conference: Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder, Program and Abstracts, pp 201–205
  4. Jensen PS, Kettle L, Roper MT et al. (in press). Are stimulants overprescribed? Treatment of ADHD in four US communities. J Am Acad Child Adolesc Psychiatry
  5. MTA Cooperative Group (in press), Fourteen-month randomized clinical trial of treatment strategies for attention deficit hyperactivity disorder. Arch Gen Psychiatry
  6. Schachar RJ, Ickowicz A, Tannock R (in press), Pharmacotherapy of ADHD. In: Handbook of Disruptive Behavior Disorders, Quay H, Hogan A, eds. New York: Plenum, pp 555–565
  7. US Drug Enforcement Administration, Office of Diversion Control (1996), Conference Report: Stimulant Use in the Treatment of ADHD. Washington, DC
  8. Vitiello B, Burke L (in press), Generic methylphenidate versus brand Ritalin: which should be used? In: Ritalin: Theory and Practice, 2nd ed, Greenhill L, Osman B, eds. Larchmont, NY: Mary Ann Liebert
  9. Winsberg, 1987, Is there dosedependent tolerance associated with chronic methylphenidate therapy in hyperactive children: oral dose and plasma concentrations, Psychopharmacol Bull, 23, 107

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Metadata

Authors
GREENHILL, L. L., HALPERIN, J. M., & ABIKOFF, H.
Affiliations
Queens College, CUNY (US)
Corresponding author
GREENHILL, LAURENCE L.
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1999-05
Volume
38
Issue
5
Pages
503-512
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/00004583-199905000-00011
OpenAlex
W4250858368
Cited by
268
References
54
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 10
FWCI
3.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (5-UO1-MH5045402, U01MH050454)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Social Sciences › Arts and Humanities › Philosophy › Neuroethics, Human Enhancement, Biomedical Innovations
Keywords
stimulant medication, attention deficit hyperactivity disorder, children, long-term safety, efficacy, adverse events, weight gain, height gain, tolerance (pharmacology and immunology), sensitization, liver tumors
MeSH terms
Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Constitution, Child, Humans, Weight Gain, Treatment Outcome

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