Changes in regional cerebral blood flow on recovery from depression
Open accessAbstract
Synopsis: We have previously described focal abnormalities of regional cerebral blood flow (rCBF) in the left dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex and angular gyrus in 40 patients with major depression. We now report on the patterns of change in rCBF in a subgroup of 25 of the same patients who were rescanned following clinical remission of depression. Fifteen patients were scanned when optimally matched for drug treatment (4) or drug free on both occasions (11). The other 10 patients were fully recovered but could not be matched for drug status for clinical and ethical reasons. In a paired comparison of the same patients when ill and following recovery it was evident that remission was associated with a significant increase in rCBF in the left DLPFC and medial prefrontal cortex including anterior cingulate. Increases in rCBF in the angular gyrus were not seen when the comparison of depressed and recovered scans was matched for medication. The previously described relationship between clinical symptoms and brain perfusion in the depressed state was no longer present in the recovered state; this supports the hypothesis of state relatedness. Thus, recovery from depression is associated with increases in rCBF in the same areas in which focal decreases in rCBF are described in the depressed state in comparison with normal controls.
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In imaging studies of traditional antidepressant treatment response, increased cortical thickness and cerebral blood flow in the PFC correlate with efficacy.
“In imaging studies of traditional antidepressant treatment response, increased cortical thickness and cerebral blood flow in the PFC correlate with efficacy (108–112).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [109]
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- Authors
- Bench, C. J., Frackowiak, R. S. J., & Dolan, R. J.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Dolan, R. J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1995-03
- Volume
- 25
- Issue
- 2
- Pages
- 247-261
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2143087778
- Cited by
- 351
- References
- 10
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 11 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 12 · 2017: 2 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- regional cerebral blood flow, major depressive disorder, recovery from depression, clinical remission, dorsolateral prefrontal cortex, anterior cingulate cortex, angular gyrus, medial prefrontal cortex, antidepressant treatment
- MeSH terms
- Adult, Aged, Antidepressive Agents, Bipolar Disorder, Brain, Depressive Disorder, Female, Follow-Up Studies, Frontal Lobe, Gyrus Cinguli, Humans, Male, Middle Aged, Personality Inventory, Reference Values, Regional Blood Flow, Tomography, Emission-Computed
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