Cited by 250Sleep and Wakefulness ResearchSleep and Work-Related FatigueCircadian rhythm and melatonin

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Partial sleep deprivation reduces natural killer cell activity in humans.

Irwin, M, Mascovich, A, Gillin, J C, Willoughby, R, Pike, J, Smith, T L·1994·Psychosomatic Medicine

DOI 10.1097/00006842-199411000-00004

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Abstract

Sleep disturbance, measured by either subjective report or electroencephalographic (EEG) assessment of sleep, correlates with a reduction of natural killer (NK) cell activity in major depression. To test whether sleep loss independent of mood disturbance alters daytime values of cellular immune function, the effect of late-night partial sleep deprivation on NK cell activity was studied in 23 medically and psychiatrically healthy male volunteers. After a night of sleep deprivation between 3 and 7 AM, NK cell activity was reduced in 18 of the 23 subjects with average lytic activity reduced significantly (p < .01) to a level 72% of the mean of three separate baseline values. After a night of resumed nocturnal sleep, NK cell activity had returned to baseline levels. These data implicate sleep in the modulation of natural immunity and demonstrate that even modest disturbances of sleep produce a reduction of NK cell activity.

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Background
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Background
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“Quality sleep is crucial for optimal health [1-3].”
Self-citation
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Background
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“One of these mechanisms is immune system dysregulation; experimental sleep deprivation has been noted to significantly reduce natural killer cell activity in healthy humans [12], and inflammation has been linked to cancer prognosis [13].”
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BackgroundSelf-citation
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“Experimental studies have also shown that the activity of natural killer cell and cellular immunity are suppressed during partial sleep loss (Irwin et al., 1994).”
Background
Medical Conditions and Diseases
Rogers, N. L., & Kloss, J. D. (2004) · CRC Press eBooks · doi:10.3109/9780203998007-6 · Cited by 3
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“Mainly due to this technical difficulty, most of the research has shifted toward total sleep deprivation or partial sleep deprivation, the latter by suppressing the second half of the night where it has been shown that the highest percentage of REM sleep occurs ( Irwin, Mascovich, Gillin, Willoughby, Pike, and Smith 1…”
Background
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Ferreira, R. C. M., Ruiz, F. S., & de Mello, M. T. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90918-1.00003-4 · Cited by 3
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Authors: Irwin, M., Mascovich, A., Gillin, J. C., Willoughby, R., Pike, J., & Smith, T. L.
Affiliations: University of California San Diego (US)
ORCID: Irwin, M
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-11
Volume: 56
Issue: 6
Pages: 493-498
ISSN: 0033-3174 (ISSN-L)
DOI: 10.1097/00006842-199411000-00004
OpenAlex: W2047973327
Cited by: 249
References: 0
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 3 · 2013: 10 · 2012: 9
FWCI: 2.58
Type: journal article
Language: en
Open access: closed
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01mh046867-01a2)
National Institute of Mental Health (MH-46867-01, MH30914)
National Center for Research Resources (M-01RR00827, M01RR000827)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep restriction, natural killer cells, cellular immune function, sleep disorders, natural immunity, major depressive disorder, nocturnal sleep, lytic activity
MeSH terms: Adult, Electroencephalography, Humans, Immunity, Cellular, Killer Cells, Natural, Lymphocytes, Male, Middle Aged, Sleep Deprivation, Sleep Stages, Sleep, REM, Stress, Psychological, Polysomnography

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Partial sleep deprivation reduces natural killer cell activity in humans.

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