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Cited by 33Influenza Virus Research StudiesCircadian rhythm and melatoninSleep and Wakefulness Research

Effects of sleep deprivation and other stressors on the immune and inflammatory responses of influenza-infected mice

Toth, Linda A., Rehg, Jerold E.·1998·Life Sciences
DOI 10.1016/s0024-3205(98)00321-x
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Abstract

Many stressors have well-documented effects on host immune competence. However, two important stressors that have not been extensively characterized in terms of their immune-modulatory properties are sleep deprivation and alterations in light:dark cycles. We therefore evaluated the effects of these stressors on the immune and inflammatory responses of mice inoculated intranasally with influenza virus. In contrast to a previous report, sleep deprivation did not significantly alter viral clearance or antibody titers of either virus-naive or immunized mice. Exposure to constant light also failed to affect these variables. However, repeated overnight restraint, a well-characterized stressor, reduced the pulmonary inflammatory response elicited by influenza virus, as previously reported. The data indicate that sleep deprivation and altered light cycles do not markedly influence selected host defense responses to influenza infection under the conditions tested.

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Crossref · 10.1016/s0024-3205(98)00321-x

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  • A biphasic time course of changes in NREM and REM sleep amount has been reported after inoculation with Staphylococcus aureus in rabbits and endotoxin in rats, such that the initial increase in NREM and suppression in REM sleep were reversed at later time points.

    “a biphasic time course of changes in NREM and REM sleep amount has been reported after inoculation with bacteria (Staphylococcus aureus) in rabbits (544) and bacterial cell wall components (endotoxin) in rats (318), such that the initial increase in NREM and suppression in REM sleep were reversed at later time points.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [544]

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Authors
Toth, L. A., & Rehg, J. E.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Toth, Linda A.
ORCID
Rehg, Jerold E.
Venue
Life Sciences
Publisher
Elsevier BV
Published
1998-07
Volume
63
Issue
8
Pages
701-709
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/s0024-3205(98)00321-x
OpenAlex
W2086495219
Cited by
33
References
25
Citations by year
2020: 1 · 2019: 1 · 2018: 1 · 2013: 2
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Lebanese Syrian Associated Charities
  • National Institutes of Health (5r01ns026429-10)
  • National Cancer Institute (CA21765, P30CA021765)
  • National Institute of Neurological Disorders and Stroke (NS-26429)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep deprivation, stress, influenza, immune response, inflammation, restraint stress, constant light, light-dark cycle, viral clearance, antibody titers, lung inflammation, host defense
MeSH terms
Amyloid, Animals, Antibodies, Viral, Light, Mice, Inbred C57BL, Orthomyxoviridae, Orthomyxoviridae Infections, Restraint, Physical, Sleep Deprivation, Stress, Physiological, Photoperiod, Mice

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