Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery
Open accessAbstract
Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic function as well as impaired immune response. Using high-resolution microarrays we evaluated the gene expression profiles of healthy male volunteers who underwent 60 h of prolonged wakefulness (PW) followed by 12 h of sleep recovery (SR). Peripheral whole blood was collected at 8 am in the morning before the initiation of PW (Baseline), after the second night of PW, and one night after SR. We identified over 500 genes that were differentially expressed. Notably, these genes were related to DNA damage and repair and stress response, as well as diverse immune system responses, such as natural killer pathways including killer cell lectin-like receptors family, as well as granzymes and T-cell receptors, which play important roles in host defense. These results support the idea that sleep loss can lead to alterations in molecular processes that result in perturbation of cellular immunity, induction of inflammatory responses, and homeostatic imbalance. Moreover, expression of multiple genes was downregulated following PW and upregulated after SR compared with PW, suggesting an attempt of the body to re-establish internal homeostasis. In silico validation of alterations in the expression of CETN3, DNAJC, and CEACAM genes confirmed previous findings related to the molecular effects of sleep deprivation. Thus, the present findings confirm that the effects of sleep loss are not restricted to the brain and can occur intensely in peripheral tissues.
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When recovery sleep was extended to 10 h per night for three nights, elevated circulating IL-6 levels resulting from 6 days of sleep restriction (6 h of sleep/night) returned to normal in healthy adults.
“However, another study showed that when recovery sleep was extended to 10 h per night for three nights, elevated circulating IL-6 levels resulting from 6 days of sleep restriction (6 h of sleep/night) returned to normal in healthy adults (432).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [432]
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Additional file 1 of Human blood serum proteome changes after 6 hours of sleep deprivation at night
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- Authors
- Pellegrino, R., Sunaga, D. Y., Guindalini, C., Martins, R. C. S., Mazzotti, D. R., Wei, Z., Daye, Z. J., Andersen, M. L., & Tufik, S.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Universidade de São Paulo (BR)
- New Jersey Institute of Technology (US)
- University of Pennsylvania (US)
- Corresponding author
- Guindalini, C.
- ORCID
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2012-11-01
- Volume
- 44
- Issue
- 21
- Pages
- 1003-1012
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2140642455
- Cited by
- 42
- References
- 99
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 3
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Physiological Genomics (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, prolonged wakefulness, sleep recovery, whole blood gene expression, peripheral blood transcriptome, DNA damage and repair, stress response, natural killer cells, granzymes, T cell receptor, immune response, inflammation, homeostasis, CEACAM
- MeSH terms
- Adult, Calcium-Binding Proteins, Circadian Rhythm, Globins, Humans, Male, Sleep, Sleep Deprivation, Wakefulness, Cell Adhesion Molecules, Genome, Human, Gene Expression Profiling, Transcriptome
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