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Cited by 376Coffee research and impactsBlood Pressure and Hypertension StudiesSodium Intake and Health

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Blood pressure response to chronic intake of coffee and caffeine: a meta‐analysis of randomized controlled trials

Open access
Noordzij, Marlies, Uiterwaal, Cuno SPM, Arends, Lidia R, Kok, Frans J, Grobbee, Diederick E, Geleijnse, Johanna M·2005·Journal of Hypertension
DOI 10.1097/01.hjh.0000166828.94699.1d
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Abstract

PURPOSE: Coffee is a widely consumed beverage and small health effects of substances in coffee may have large public health consequences. It has been suggested that caffeine in coffee increases the risk of hypertension. We performed a meta-analysis of randomized controlled trials of coffee or caffeine and blood pressure (BP). DATA IDENTIFICATION: BP trials of coffee or caffeine published between January 1966 and January 2003 were identified through literature databases and manual search. STUDY SELECTION: A total of 16 studies with a randomized, controlled design and at least 7 days of intervention was selected, comprising 25 strata and 1010 subjects. DATA EXTRACTION: Two persons independently obtained data on sample size, type and duration of intervention, changes in BP and heart rate (HR), and subjects' characteristics for each trial. Meta-analysis was performed using a random-effects model. RESULTS: A significant rise of 2.04 mmHg [95% confidence interval (CI), 1.10-2.99] in systolic BP and 0.73 mmHg (95% CI, 0.14-1.31) in diastolic BP was found after pooling of coffee and caffeine trials. When coffee trials (n = 18, median intake: 725 ml/day) and caffeine trials (n = 7, median dose: 410 mg/day) were analysed separately, BP elevations appeared to be larger for caffeine [systolic: 4.16 mmHg (2.13-6.20); diastolic: 2.41 mmHg (0.98-3.84)] than for coffee [systolic: 1.22 mmHg (0.52-1.92) and diastolic: 0.49 mmHg (-0.06-1.04)]. Effects on HR were negligible. CONCLUSIONS: Regular caffeine intake increases BP. When ingested through coffee, however, the blood pressure effect of caffeine is small.

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Metadata

Authors
Noordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M.
Affiliations
  • Utrecht University (NL)
  • Erasmus University Rotterdam (NL)
  • Wageningen University & Research (NL)
Corresponding author
Geleijnse, Johanna M
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-05
Volume
23
Issue
5
Pages
921-928
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/01.hjh.0000166828.94699.1d
OpenAlex
W2091257623
Cited by
376
References
35
Citations by year
2026: 9 · 2025: 7 · 2024: 12 · 2023: 22 · 2022: 13 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 20 · 2015: 21 · 2014: 20 · 2013: 22 · 2012: 30
FWCI
2.76
Type
journal article
Language
en
Open access
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
coffee, caffeine, blood pressure, hypertension, systolic blood pressure, diastolic blood pressure, heart rate, caffeine consumption
MeSH terms
Adult, Aged, Blood Pressure, Coffee, Female, Heart Rate, Humans, Male, Middle Aged

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