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Blood pressure response to chronic intake of coffee and caffeine: a meta‐analysis of randomized controlled trials
Open accessAbstract
PURPOSE: Coffee is a widely consumed beverage and small health effects of substances in coffee may have large public health consequences. It has been suggested that caffeine in coffee increases the risk of hypertension. We performed a meta-analysis of randomized controlled trials of coffee or caffeine and blood pressure (BP). DATA IDENTIFICATION: BP trials of coffee or caffeine published between January 1966 and January 2003 were identified through literature databases and manual search. STUDY SELECTION: A total of 16 studies with a randomized, controlled design and at least 7 days of intervention was selected, comprising 25 strata and 1010 subjects. DATA EXTRACTION: Two persons independently obtained data on sample size, type and duration of intervention, changes in BP and heart rate (HR), and subjects' characteristics for each trial. Meta-analysis was performed using a random-effects model. RESULTS: A significant rise of 2.04 mmHg [95% confidence interval (CI), 1.10-2.99] in systolic BP and 0.73 mmHg (95% CI, 0.14-1.31) in diastolic BP was found after pooling of coffee and caffeine trials. When coffee trials (n = 18, median intake: 725 ml/day) and caffeine trials (n = 7, median dose: 410 mg/day) were analysed separately, BP elevations appeared to be larger for caffeine [systolic: 4.16 mmHg (2.13-6.20); diastolic: 2.41 mmHg (0.98-3.84)] than for coffee [systolic: 1.22 mmHg (0.52-1.92) and diastolic: 0.49 mmHg (-0.06-1.04)]. Effects on HR were negligible. CONCLUSIONS: Regular caffeine intake increases BP. When ingested through coffee, however, the blood pressure effect of caffeine is small.
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Mechanisms of action of coffee bioactive compounds – a key to unveil the coffee paradox
Machado, F. D. S., Coimbra, M. A., del Castillo, M. D., & Coreta-Gomes, F. M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2221734 · Cited by 69
An examination of consumer exposure to caffeine from retail coffee outlets
Desbrow, B., Hughes, R., LEVERITT, M. D., & Scheelings, P. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.02.020 · Cited by 60
Papakonstantinou, E., Kechribari, I., Sotirakoglou, Κ., Tarantilis, P., Gourdomichali, T., Michas, G., Kravvariti, V., Voumvourakis, K., & Zampelas, A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0146-0 · Cited by 59
“However, other studies have shown that the type of coffee may have a different impact on BP suggesting that boiled coffee may cause a higher increase in BP compared to filtered coffee, whereas instant coffee and decaf do not affect BP, after daily consumption of large coffee doses (>5 cups) for several days and/or wee…”
ResultCoffee consumption and cardiometabolic health: a comprehensive review of the evidence
Ungvari, Z. I., & Kunutsor, S. K. (2024) · GeroScience · doi:10.1007/s11357-024-01262-5 · Cited by 69
Metadata
- Authors
- Noordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M.
- Affiliations
- Utrecht University (NL)
- Erasmus University Rotterdam (NL)
- Wageningen University & Research (NL)
- Corresponding author
- Geleijnse, Johanna M
- ORCID
- Venue
- Journal of Hypertension
- Published
- 2005-05
- Volume
- 23
- Issue
- 5
- Pages
- 921-928
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2091257623
- Cited by
- 376
- References
- 35
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 12 · 2023: 22 · 2022: 13 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 20 · 2015: 21 · 2014: 20 · 2013: 22 · 2012: 30
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- coffee, caffeine, blood pressure, hypertension, systolic blood pressure, diastolic blood pressure, heart rate, caffeine consumption
- MeSH terms
- Adult, Aged, Blood Pressure, Coffee, Female, Heart Rate, Humans, Male, Middle Aged
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